Aminophenols
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | 99.9% | 163.60 g·mol⁻¹ | C6H10ClNO2 | 100 MG
Guvacine hydrochloride is a research reagent used to inhibit GABA uptake in neuropharmacology and biochemical studies. It is supplied as a white to off-white solid and is available in both solid and small-solution formats for in vitro experiments.
- Functions as a GABA uptake inhibitor for neuropharmacology research.
- High purity (~99.9%) minimizes impurities in assays.
- Available as solids and as a DMSO solution for experimental flexibility.
- White to off-white solid suitable for analytical and in vitro use.
- Molecular weight 163.60 g·mol⁻¹ supports accurate stoichiometry calculations.
Medchemexpress LLC NPS-2143 hydrochloride | 324523-20-8 | MFCD16038896; MFCD04113010 | 100.0% | 445.38 g/mol | C24H26Cl2N2O2 | 50 MG
NPS-2143 hydrochloride is an orally active calcilytic small molecule that selectively antagonizes the calcium-sensing receptor (CaSR), inhibiting CaSR-mediated increases in intracellular Ca2+. It is supplied as a solid at high purity for use in biochemical and pharmacological research into CaSR signaling and related physiological pathways.
- Selective CaSR antagonist for CaSR signaling studies.
- Orally active calcilytic small molecule suitable for in vitro and in vivo research.
- High purity solid appropriate for research applications.
- Molecular weight 445.38 g/mol and chemical formula C24H26Cl2N2O2.
- Available in small research quantities, including 50 MG.
- Applicable to biochemical, cellular, and pharmacological assays.
Medchemexpress LLC AC-099 hydrochloride | 849335-07-5 | C9H9Cl2F3N4 | 50 MG
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). It has been shown to attenuate spinal nerve ligation-induced hypersensitivity in rats. This product is for research use only.
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Appearance: Solid, white to off-white
- Purity: 99.92%
- Molecular weight: 301.10
Medchemexpress LLC dTAGV-1 hydrochloride | 2624313-16-0 | 99.9% | C68H91ClN6O14S | 1 MG
dTAGV-1 hydrochloride is a potent and selective PROTAC degrader designed for FKBP12F36V-tagged proteins. This compound is capable of inducing the degradation of FKBP12F36V-Nluc both in vitro and in vivo, offering a valuable tool for targeted protein degradation research.
- Potent and selective degrader of FKBP12F36V-tagged proteins
- Induces degradation of FKBP12F36V-Nluc in vivo
- Composed of a Target Protein Ligand, Linker, and VHL Ligand
- Shows potent degradation of FKBP12F36V-Nluc in 293FT cells with no effects on FKBP12WT-Nluc
Medchemexpress LLC AFM-30a hydrochloride | 99.8% | 502.97 | 1 ML
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. It inhibits H3 citrullination and is intended for research into certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
- Potent protein arginine deiminase 2 (PAD2) inhibitor.
- Excellent PAD2-selectivity.
- Inhibits H3 citrullination.
- Can be used for research of certain cancers and autoimmune diseases.
- Exhibited low cytotoxicity for cells in a cell viability assay.
- Suppresses NLRP3 signaling and decreases airway remodeling.
Medchemexpress LLC L-NAME (hydrochloride) | 51298-62-5 | 99.89% | 269.69 | 1 G
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to the NOS inhibitor L-NOARG, which has an IC50 value of 1.4 μM. This product can also be utilized to induce hypertension and preeclampsia models.
- Inhibits NOS with an IC50 of 70 μM.
- Functions as a precursor to the NOS inhibitor L-NOARG, which has an IC50 of 1.4 μM.
- Applicable for inducing hypertension models.
- Applicable for inducing preeclampsia models.
Medchemexpress LLC Melk-8a (hydrochloride) | 2096992-20-8 | 99.3% | 469.02 | C25H33ClN6O | 500 MG
MELK-8a hydrochloride is a potent, selective inhibitor of maternal embryonic leucine zipper kinase (MELK) with an enzymatic IC50 of 2 nM. Supplied as the hydrochloride salt, the compound shows cellular activity in cancer cell lines, with reported good solubility and permeability, and is intended for research use only.
- Potent MELK inhibition (IC50 2 nM).
- High purity (>99%).
- Good solubility and permeability in cellular assays.
- Demonstrated activity in cancer cell lines (MDA-MB-468, MCF-7).
- Documentation available: product data sheet and safety data sheet.
Medchemexpress LLC RS102895 hydrochloride | 1173022-16-6 | 99.9% | 426.86 | 50 MG
Abaucin hydrochloride (RS102895 hydrochloride) is a potent CCR2 antagonist (IC50 = 360 nM) that also inhibits human α1a and α1d receptors, and the rat brain cortex 5HT1a receptor. It ameliorates extracellular matrix (ECM) protein expression and blocks fibronectin and type IV collagen expression in high glucose-stimulated mesangial cells.
- Potent CCR2 antagonist.
- Inhibits human α1a and α1d receptors.
- Suppresses MCP-1 receptor activity.
- Ameliorates extracellular matrix protein expression.
- Blocks fibronectin and type IV collagen expression.
- Reverses NR2B, nNOS, and SIGIRR expression in spinal cord.
Medchemexpress LLC CC-401 (hydrochloride) | 1438391-30-0 | 99.35% | 1 ML
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK. It competitively binds the ATP binding site in JNK, inhibiting the phosphorylation of the N-terminal activation domain of the transcription factor c-Jun. It offers at least 40-fold selectivity for JNK compared with other related kinases.
- Potent JNK inhibitor
- High selectivity for JNK
- Inhibits phosphorylation of c-Jun
- Suitable for laboratory centrifugation and storage
Medchemexpress LLC Sotorasib-d7 | 2296729-00-3 | 98.9% | 567.64 | 10 MG
Sotorasib-d7 is a deuterium-labeled Sotorasib and a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Deuterium-labeled Sotorasib.
- First-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor.
- Irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.
- Leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC MS8511 (hydrochloride) | 3031788-28-7 | C28H42ClN5O3 | 1 MG
MS8511 hydrochloride is a chemical compound for research use, identified as 2-Propenamide, N-[6-methoxy-4-[[1-(1-methylethyl)-4-piperidinyl]amino]-7-[3-(1-pyrrolidinyl)propoxy]-2-quinolinyl]-, hydrochloride (1:1). It appears as an off-white to light yellow solid and has a purity of 98.07% by LCMS. This product is intended for laboratory chemicals and manufacture of substances.
- For research use only
- Off-white to light yellow solid appearance
- Purity of 98.07%
- Stable under recommended storage conditions
- Recommended storage for powder: -20°C for 3 years
- Recommended storage for in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC CP94253 hydrochloride | 845861-39-4 | MFCD03453293 | 98.8% | 293.79 g·mol⁻¹ | C15H20ClN3O | 1 ML
CP94253 hydrochloride is a potent, selective serotonin 5-HT1B receptor agonist supplied for research use and commonly provided as a 10 mM solution in DMSO for in vitro and in vivo studies.
- Potent 5-HT1B agonist (Ki ≈ 2 nM).
- High purity (≈98.8%).
- Supplied as a 10 mM, 1 mL solution in DMSO; also available as solid in multiple milligram quantities.
- Chemical formula C15H20ClN3O; molecular weight 293.79 g·mol⁻¹.
- Light yellow solid appearance; store sealed and away from moisture; in solvent: -80°C (up to 6 months) or -20°C (1 month).
Medchemexpress LLC dTAGV-1 hydrochloride | 2624313-16-0 | 99.9% | C68H91ClN6O14S | 50 MG
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. It can induce degradation of FKBP12F36V-Nluc in vivo.
- Target protein ligand
- Linker
- VHL ligand
- VHL ligand and linker
Medchemexpress LLC RGX-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 25 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. This compound is for research use only and not sold to patients. Studies show it significantly suppresses the growth of multiple cancer types in animals, even in large tumors, with instances of partial or complete tumor regression.
- Acts as a small-molecule LXR agonist
- Modulates innate immunity through ApoE gene activation
- Significantly suppresses various cancer types in animal models
- Effective against large tumors, with potential for regression
- Applicable across a wide spectrum of malignancies
Medchemexpress LLC V-9302 hydrochloride | 2416138-42-4 | 99.1% | 575.14 | 25 MG
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5), but not ASCT1. It inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells.
- Inhibits ASCT2-mediated glutamine uptake in human cells.
- Shows improved potency over gamma-L-glutamyl-p-nitroanilide.
- Attenuates cancer cell growth and proliferation.
- Increases cell death and oxidative stress.
- Prevents tumor growth in xenograft models.
- Elicits strong growth inhibition in xenograft models when combined with CB-839.
- Reduces tumor growth.