Aminophenols
Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 25 MG
BI-9627 hydrochloride is a potent and selective sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50 values of 6 nM and 31 nM. It demonstrates high selectivity over other NHE isoforms and has shown effects on autophagy, pH regulation, and Ca2+ recovery in various cell types. This compound exhibits favorable pharmacokinetic properties and cardioprotective activity. For research use only.
- Potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM).
- High selectivity (>30-fold) against NHE2; no activity against NHE3.
- Decreases autophagy in HTR-8/SVneo cells.
- Reduces pHi of human sperm and partially reverses DMA effect.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Low drug-drug interaction (DDI) potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart model of ischemia-reperfusion injury.
![Medchemexpress LLC 4-Piperidinecarboxamide, N-hydroxy-1-(2-methoxyethyl)-4-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-, hydrochloride (1:1) | 226395-93-3 | 99.4% | 554.96 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 4-Piperidinecarboxamide, N-hydroxy-1-(2-methoxyethyl)-4-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-, hydrochloride (1:1) | 226395-93-3 | 99.4% | 554.96 | 10 MG
SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of <0.1, <0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. It inhibits dilation of the left ventricle in rats. This product is for research use only.
- Potent MMP inhibitor
- Inhibits dilation of the left ventricle in rats
- Solid appearance
- White to off-white color
- Ships at room temperature
- Store at -20°C, sealed, away from moisture
- Soluble in DMSO at 55.5 mg/mL
Medchemexpress LLC RGX-104 (hydrochloride) | 610318-03-1 | 99.9% | 632.54 | 10 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. It is for research use only and not sold to patients.
- LXR agonist
- Modulates innate immunity via transcriptional activation of the ApoE gene
- Oral administration significantly suppresses the growth of multiple cancer types (e.g., lung cancer, melanoma, glioblastoma, ovarian, renal cell, triple-negative breast, and colon cancer) in animals with palpable tumors.
- Can cause partial or complete tumor regression in some instances.
Medchemexpress LLC BN82002 hydrochloride | 1049740-43-3 | 99.4% | 395.88 | 50 MG
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. The compound demonstrates approximately 20-fold greater selectivity over CD45 tyrosine phosphatase and inhibits cell proliferation in several human tumor cell lines in a concentration-dependent manner in the low micromolar range. Treatment with 50 μM BN82002 modestly affects cell cycle distribution, suggesting cell cycle arrest at various stages.
- Potent, selective, and irreversible inhibitor of CDC25 phosphatase family.
- Displays approximately 20-fold greater selectivity over CD45 tyrosine phosphatase.
- Inhibits cell proliferation in various human tumor cell lines.
- For research use only.
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.29% | 100 MG
SKI-178 is a potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2. It exhibits cytotoxicity at IC50 concentrations ranging from 0.1 to 1.8 μM in various cancer cell lines, including MTR3, NCI-ADR, and HL60/VCR cells. SKI-178 induces apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and has been shown to inhibit leukemic progression in an MLL-AF9 mouse model.
- Potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2
- Exhibits cytotoxicity in multiple cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cell lines
- Inhibits leukemic progression in MLL-AF9 mouse model
- Purity of 99.29%
- Soluble in DMSO for in vitro experiments
- Formulations suitable for oral and intraperitoneal injection for in vivo studies
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | 98.5% | 280.75 g/mol | C14H17ClN2O2 | 5 MG
Imiloxan hydrochloride is a potent, selective α2B-adrenoceptor antagonist used in pharmacological research to probe α2-adrenergic receptor subtype function. It is supplied as a characterized solid with defined purity and molecular weight for use in receptor-binding studies, in vitro assays, and in vivo experiments.
- Selective α2B-adrenoceptor antagonist
- High purity suitable for research applications
- Supplied in small research pack sizes for lab use
- Supported by analytical data (HNMR, LC-MS)
- Provided with SDS, COA, and handling instructions
Medchemexpress LLC DC-Chol hydrochloride | 166023-21-8 | >99.9% | 537.26 | 250 MG
DC-Chol hydrochloride is a cationic lipid that inhibits Aβ40 fibril formation and amyloidogenesis of oxidized hCT. It enhances the body's immune response to antigens by inducing the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. This compound is also utilized as a gene delivery vector.
- Can inhibit Aβ40 fibril formation
- Strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner
- Induces production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines
- Enhances the body's immune response to antigens
- Used as a gene delivery vector
- Can be used in research for hepatitis B vaccines to improve vaccine immunity
Medchemexpress LLC SAR7334 hydrochloride | 1333207-63-8 | 98.0% | 440.79 g/mol | C21H24Cl3N3O | 10 MG
SAR7334 hydrochloride is the hydrochloride salt of SAR7334, a potent and selective small-molecule inhibitor of the TRPC6 ion channel. It inhibits TRPC6 currents with an IC50 of 7.9 nM and is supplied as a high-purity research reagent for biochemical and cellular studies.
- Potent TRPC6 inhibitor (IC50 7.9 nM).
- Hydrochloride salt form for improved stability and solubility.
- Purity: 98.0% (as supplied).
- Molecular weight: 440.79 g/mol.
- Available as milligram quantities and as a 10 mM solution in DMSO.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Sotalol hydrochloride | 959-24-0 | MFCD00242937 | 99.9% | 308.82 g/mol | C12H21ClN2O3S | 10 MG
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with class III antiarrhythmic activity used in cardiovascular and electrophysiology research. It is supplied as a characterized research chemical with high purity and documented analytical data.
- High purity as determined by LCMS (≈99.9%).
- Molecular weight 308.82 g/mol and molecular formula C12H21ClN2O3S.
- Used to study β-receptor blockade and cardiac repolarization (potassium channel) effects.
- Supplied in small research pack sizes and solution formats (for example, 10 MG solid or 10 mM/1 mL solution).
eMolecules 101-18-8 | 3-Hydroxydiphenylamine | Combi-Blocks | MFCD00002262 | 185.226 | C12H11NO | 98.000 | Oc1cccc(Nc2ccccc2)c1 | 1g | 290690778
3-Hydroxydiphenylamine | Combi-Blocks | 101-18-8 | MFCD00002262 | 185.226 | C12H11NO | 98.000 | Oc1cccc(Nc2ccccc2)c1 | 1g | 290690778
Medchemexpress LLC ZM39923 hydrochloride | 1021868-92-7 | MFCD04974534 | 99.8% | 367.91 g/mol | C23H26ClNO | 5MG
ZM39923 hydrochloride is a research-grade small molecule that acts primarily as a JAK3 inhibitor (pIC50 = 7.1) and also potently inhibits tissue transglutaminase (TGM2) (IC50 ≈ 10 nM). It displays weaker activity against EGFR and JAK1 and minimal activity versus Lck and CDK4. Supplied as the hydrochloride salt with high reported purity, it is intended for laboratory research use only.
- JAK3 inhibitor with pIC50 7.1.
- Potent tissue transglutaminase (TGM2) inhibition (IC50 ≈ 10 nM).
- Hydrochloride salt form for improved stability and handling.
- High reported purity (around 99.8%).
- Available as solid and as a DMSO solution format.
- Intended for research use only; not for diagnostic or therapeutic use.
Medchemexpress LLC Tas4464 (hydrochloride) | 1848959-11-4 | 98.9% | 25 MG
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It exhibits antiproliferative and cytotoxic effects with broad-spectrum antitumor activity against various hematologic and solid tumor cell lines and patient-derived tumor cells. This compound has a wide therapeutic window without obvious toxicity and is suitable for research in hematologic malignancies and solid tumors.
- Highly potent and selective NAE inhibitor
- Demonstrates broad-spectrum antitumor activity against various cancer models
- Induces tumor cell apoptosis
- Increases protein expression levels of CRL ubiquitin ligase substrates
- Inhibits migratory capacity of solid tumor cell lines
- Achieves complete tumor regression in various animal models
- Prolongs survival and reduces tumor burden in lymphoma models
- Possesses a wide therapeutic window without obvious toxicity
eMolecules 258331-10-1 | TERT-BUTYL 2-(2-HYDROXYPHENYL)ACETATE | AstaTech | MFCD25019077 | 208.257 | C12H16O3 | 95.000 | CC(C)(C)OC(=O)Cc1ccccc1O | 1g | 335884869
TERT-BUTYL 2-(2-HYDROXYPHENYL)ACETATE | AstaTech | 258331-10-1 | MFCD25019077 | 208.257 | C12H16O3 | 95.000 | CC(C)(C)OC(=O)Cc1ccccc1O | 1g | 335884869
Medchemexpress LLC Csrm617 hydrochloride | 1353749-74-2 | 100.0% | 25 MG
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2). It binds the OC2-HOX domain (Kd 7.43 μM in SPR assays), induces apoptosis in preclinical models, and is supplied as a high-purity solid suitable for in vitro and in vivo studies.
- Selective ONECUT2 inhibitor with documented apoptosis induction.
- High purity: 99.97%.
- Available in multiple solid pack sizes including 25 MG.
- Soluble in DMSO: 100 mg/mL; several in vivo formulation protocols provided.
- Storage: solid at -20°C; solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | MFCD01074788 | >98.0% | 280.75 | C14H17ClN2O2 | 25 MG
Imiloxan hydrochloride is the hydrochloride salt of imiloxan, a potent and selective α2B-adrenoceptor antagonist used in pharmacology research. Supplied as a solid reagent, it is intended for distinguishing α2 receptor subtypes and for probing adrenergic signaling in both in vitro and in vivo studies.
- Potent, selective α2B-adrenoceptor antagonist for receptor pharmacology.
- Suitable for both in vitro and in vivo pharmacodynamic studies.
- High purity (≥98% HPLC) supporting reproducible results.
- Hydrochloride salt form improves aqueous solubility for dosing.
- Available in small research pack sizes appropriate for screening and dosing.
- Molecular formula C14H17ClN2O2; molecular weight 280.75 g/mol.