Aminophenols
Medchemexpress LLC Sotalol hydrochloride | 959-24-0 | 99.9% | 500 MG
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker. It is a potent antiarrhythmic agent used for the research of pediatric arrhythmias. This compound blocks β-receptors and potassium KCNH2 channels, and acts as an antiepileptic agent.
- Orally active
- Non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Used for the research of pediatric arrhythmias
- Blocks β-receptors
- Blocks potassium KCNH2 channels
- Acts as an antiepileptic agent
Medchemexpress LLC AC-099 hydrochloride | 849335-07-5 | C9H9Cl2F3N4 | 50 MG
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). It has been shown to attenuate spinal nerve ligation-induced hypersensitivity in rats. This product is for research use only.
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Appearance: Solid, white to off-white
- Purity: 99.92%
- Molecular weight: 301.10
Medchemexpress LLC SM-433 hydrochloride | 98.6% | 598.18 | 25 MG
SM-433 hydrochloride is a Smac mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs). It demonstrates strong binding affinity to the XIAP BIR3 protein with an IC50 of less than 1 μM. This product is for research use only and not for sale to patients.
- Smac mimetic
- Inhibitor of inhibitor of apoptosis proteins (IAPs)
- Strong binding affinity to XIAP BIR3 protein (IC50 < 1 μM)
- Exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s < 10 μM) in vitro
Medchemexpress LLC SKI-I 25mg | 306301-68-8 | 25 MG
SKI-I is a research-grade small-molecule inhibitor of sphingosine kinase used in biochemical and cell-based assays to study sphingolipid signaling and apoptosis. Not for human use.
- Potent sphingosine kinase inhibitor (IC50 1.2 μM for ST-hSK).
- Also inhibits hERK2 (IC50 11 μM).
- Induces apoptosis in multiple tumor cell lines.
- High purity (99.14%).
- Soluble in DMSO at 100 mg/mL for in vitro applications.
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | 99.45% | C16H21N3O3S | 100 MG
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals. It conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1.
- Biotin-phenol analog
- Generates free radicals
- Efficiently conjugates to tyrosine residues in proteins
- More selective than BP1
- Molecular weight: 335.42
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.94% | 394.86 | 1 ML
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily Rho GTPases. It works by binding to RhoA, inhibiting its interaction with GEF proteins. This compound does not interact with Cdc42, Rac1, or LARG. It promotes stress resiliency and induces cell apoptosis, making it suitable for various research applications.
- Specifically inhibits RhoA subfamily Rho GTPases
- Induces cell apoptosis
- Promotes stress resiliency by enhancing D1-MSN plasticity
- Reduces hyperexcitability
- Does not interact with Cdc42, Rac1, or LARG
Medchemexpress LLC L-NAME (hydrochloride) | 51298-62-5 | 99.89% | 269.69 | 1 G
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to the NOS inhibitor L-NOARG, which has an IC50 value of 1.4 μM. This product can also be utilized to induce hypertension and preeclampsia models.
- Inhibits NOS with an IC50 of 70 μM.
- Functions as a precursor to the NOS inhibitor L-NOARG, which has an IC50 of 1.4 μM.
- Applicable for inducing hypertension models.
- Applicable for inducing preeclampsia models.
eMolecules 263717-53-9 | Medchem Express | Propyl pyrazole triol | 5mg | 475641433 | HY-100689 | MFCD03453628 | 386.451 | C24H22N2O3
Ambeed | 1245-Tetrabromobenzene | 1g | 642080428 | A248034 | 636-28-2 | MFCD00000063 | 393.698 | C6H2Br4
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Medchemexpress LLC Melk-8a (hydrochloride) | 2096992-20-8 | 99.3% | 469.02 | C25H33ClN6O | 500 MG
MELK-8a hydrochloride is a potent, selective inhibitor of maternal embryonic leucine zipper kinase (MELK) with an enzymatic IC50 of 2 nM. Supplied as the hydrochloride salt, the compound shows cellular activity in cancer cell lines, with reported good solubility and permeability, and is intended for research use only.
- Potent MELK inhibition (IC50 2 nM).
- High purity (>99%).
- Good solubility and permeability in cellular assays.
- Demonstrated activity in cancer cell lines (MDA-MB-468, MCF-7).
- Documentation available: product data sheet and safety data sheet.
Medchemexpress LLC MK-8033 hydrochloride | 1283000-43-0 | MFCD18633221 | ≥98.0% | C24H22Cl2N6O | 10MG
MK-8033 hydrochloride is a small-molecule, ATP-competitive dual inhibitor of c-Met and Ron kinases supplied as the hydrochloride salt for research use. It has been used in oncology research and was evaluated in early clinical trials; supplier listings report high purity and analytical characterization for laboratory applications.
- Potent dual c-Met and Ron kinase inhibitor
- Hydrochloride salt form
- Purity ≥98.0%
- Characterized by molecular formula and molecular weight
- Intended for research use in oncology studies
- Documented in early-phase clinical investigations
Medchemexpress LLC CC-401 (hydrochloride) | 1438391-30-0 | 99.35% | 1 ML
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK. It competitively binds the ATP binding site in JNK, inhibiting the phosphorylation of the N-terminal activation domain of the transcription factor c-Jun. It offers at least 40-fold selectivity for JNK compared with other related kinases.
- Potent JNK inhibitor
- High selectivity for JNK
- Inhibits phosphorylation of c-Jun
- Suitable for laboratory centrifugation and storage
Medchemexpress LLC Sotorasib-d7 | 2296729-00-3 | 98.9% | 567.64 | 10 MG
Sotorasib-d7 is a deuterium-labeled Sotorasib and a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Deuterium-labeled Sotorasib.
- First-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor.
- Irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.
- Leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | MFCD00953081 | 99.6% | 462.89 g·mol⁻1 | C20H26ClF3N4O3 | 50 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research. It is supplied as a white to off-white solid with high reported purity, and is suitable for in vitro and in vivo studies of α1A-adrenoceptor signaling and pharmacology.
- High purity (99.57%), white to off-white solid.
- Selective α1A-adrenoceptor antagonist for receptor pharmacology studies.
- Suitable for in vitro and in vivo research applications.
- Molecular weight 462.89 g·mol⁻1; formula C20H26ClF3N4O3.
- Store at 4°C and protect from light; solutions: -80°C (6 months) or -20°C (1 month).
- Supplied in 50 mg quantities.
Medchemexpress LLC Ozanimod (hydrochloride) | 1618636-37-5 | 98.1% | 1 ML
Ozanimod hydrochloride 10 mM in DMSO (1 mL) is a ready-to-use research reagent for studying sphingosine 1-phosphate (S1P) receptor modulation in preclinical and biochemical assays. Supplied as a solution to improve handling and reproducibility. For research use only; not for human use.
- Ready-to-use 10 mM solution in DMSO.
- Supplied as a 1 mL aliquot for small-scale experiments.
- Listed purity 98.1% for consistent experimental results.
- Molecular weight 440.92 g/mol and formula C23H25ClN4O3.
- Intended for research use only; not for clinical or human use.
Medchemexpress LLC Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 5 MG
Ozanimod hydrochloride is the hydrochloride salt of ozanimod, a selective sphingosine 1-phosphate (S1P) receptor modulator used in research on immune-mediated disorders such as relapsing multiple sclerosis. It is supplied as a white to off-white solid with high purity for in vitro and in vivo pharmacology studies.
- High purity (98.1%).
- Molecular weight 440.92 g/mol; formula C23H25ClN4O3.
- Soluble in DMSO at ≥ 200 mg/mL for stock solutions.
- Suitable for in vitro and in vivo pharmacology applications.
- Supplied as a 5 MG quantity.
- Store sealed at 4°C; in solvent store -80°C for up to 6 months or -20°C for 1 month.