Aminophenols
Medchemexpress LLC MRE-269-d7 | 1265295-20-2 | 99.6% | C25H22D7N3O3 | 5 MG
MRE-269-d7 is a deuterium-labeled version of MRE-269, an active metabolite of selexipag that acts as a selective IP receptor agonist. It is intended for research use and can serve as a tracer and an internal standard for quantitative analysis. Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled version of MRE-269
- Active metabolite of selexipag
- Selective IP receptor agonist
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC MT-7716 hydrochloride | 1215859-93-0 | 99.1% | 477.00 g/mol | C27H29ClN4O2 | 5 MG
MT-7716 hydrochloride is the hydrochloride salt of a selective, non-peptide nociceptin (NOP) receptor agonist used in preclinical pharmacology research. It is provided as a high-purity solid for use in in vitro assays and in vivo studies investigating alcohol abuse and relapse prevention.
- High purity solid suitable for research applications.
- Soluble in DMSO at ≥ 100 mg/mL for in vitro use.
- Manufacturer-recommended in vivo formulations available for dosing.
- Storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
- Molecular weight 477.00 g/mol; molecular formula C27H29ClN4O2.
Medchemexpress LLC Mepazine hydrochloride | 2975-36-2 | 99.3% | 5 MG
Mepazine hydrochloride is the hydrochloride salt of mepazine, supplied for research use as a solid or as a DMSO solution and intended for in vitro biochemical and cellular assays.
- High purity (99.25%).
- Molecular formula C19H23ClN2S.
- Molecular weight 346.92 g/mol.
- Available in small solid packs and a 10 mM DMSO solution format.
- Store sealed at 4°C; in solution, store at -80°C for long-term stability.
Medchemexpress LLC BIIL-260 hydrochlori 10mg | 192581-24-1 | 10 MG
Biil-260 hydrochloride is the hydrochloride salt of BIIL-260, a potent, orally active leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It binds the human LTB4 receptor reversibly and competitively (reported Ki ≈ 1.7 nM) and is supplied as a high-purity solid for research use.
- Potent LTB4 receptor antagonist with reported high affinity (Ki ≈ 1.7 nM).
- High purity solid suitable for in vitro and preclinical research.
- Available in small milligram quantities for compound screening and assay development.
- Soluble in DMSO for preparation of concentrated stock solutions.
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.79% | 353.88 | 5 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM.
- Exhibits good neuroprotective effects.
- Can improve motor function and motor neuron survival in mice.
- Can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
Medchemexpress LLC LDC4297 hydrochloride | 2319747-14-1 | 98.2% | 1 ML
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. It inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. This product shows broad antiviral activities against Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae, with EC50 values ranging from 0.02-1.21 μM. It can be used for infection research.
- Dose-dependently inhibits HCMV replication with an EC50 of 24.5 nM
- Shows anti-proliferative activity in primary human fibroblast cultures with a GI50 of 4.5 μM
- Exhibits anti-HCMV activity by interfering with virus-induced Rb phosphorylation
- Demonstrates broad antiviral activities against various viruses including HCMV, GPCMV, MCMV, HIV-1, and Influenza A virus
Medchemexpress LLC Axc-715 hydrochloride | 2490497-93-1 | 99.5% | 347.89 g/mol | C18H26ClN5 | 5 MG
AXC-715 hydrochloride is the hydrochloride salt of a small-molecule TLR7/TLR8 dual agonist used in preclinical research as an immunostimulant and as a building block for antibody-adjuvant immunoconjugates. It is supplied as a high-purity solid suitable for in vitro and in vivo studies, with recommended storage conditions to maintain stability.
Medchemexpress LLC SKI V | 24418-86-8 | 99.0% | 100 MG
SKI V is a potent, noncompetitive non-lipid sphingosine kinase (SPHK) inhibitor with an IC50 of 2 μM for GST-hSK. It also inhibits PI3K with an IC50 of 6 μM. This compound reduces the formation of sphingosine-1-phosphate (S1P), induces apoptosis, and demonstrates antitumor activity. It appears as a light yellow to yellow solid.
- Potently inhibits sphingosine kinase (SPHK)
- Inhibits PI3K
- Reduces sphingosine-1-phosphate (S1P) formation
- Induces apoptosis
- Exhibits antitumor activity
- Weak activity towards ERK2
- Does not inhibit PKC-α
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 2 MG
SR9011 hydrochloride is a potent REV-ERBα/β agonist (IC50s: 790 nM for REV-ERBα, 560 nM for REV-ERBβ). It significantly increases REV-ERB-dependent repressor activity and suppresses transcription via full-length REV-ERBα. The compound inhibits BMAL1 mRNA expression in HepG2 cells and suppresses breast cancer cell proliferation by halting the cell cycle before M phase. In mice, SR9011 suppresses REV-ERB responsive genes and temporarily reduces locomotor activity during the dark phase.
- Potent REV-ERBα/β agonist.
- Increases REV-ERB-dependent repressor activity.
- Suppresses transcription via full-length REV-ERBα.
- Inhibits BMAL1 mRNA expression in HepG2 cells.
- Suppresses breast cancer cell proliferation.
- Pauses cell cycle prior to M phase, increasing G0/G1 phase cells.
- Suppresses REV-ERB responsive genes in mice.
- Reduces locomotor activity in mice under dark conditions.
Medchemexpress LLC GSK 690 Hydrochlorid 100mg | 2436760-79-9 | 405.92 | C24H24ClN3O | 100 MG
GSK 690 hydrochloride is a reversible small-molecule inhibitor of lysine-specific demethylase 1 (LSD1) with a reported Kd of 9 nM and a biochemical IC50 of 37 nM. It is supplied as a light yellow to yellow solid (CAS 2436760-79-9) with reported purity of 98.58% and high solubility in DMSO.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 98.97% | 515.50 | 100 MG
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is for research use only.
- Increases REV-ERB-dependent repressor activity.
- Suppresses proliferation of breast cancer cell lines, regardless of ER or HER2 status.
- Causes cell cycle arrest prior to M phase by suppressing Cyclin A (CCNA2).
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
- Displays reasonable plasma exposure in vivo.
Medchemexpress LLC P-amidinophenylmethylsulfonylfluoride hydrochloride | 74938-88-8 | MFCD00078902 | 95.0% | 252.69 | C8H10ClFN2O2S | 1 MG
p-APMSF hydrochloride is the hydrochloride salt of p-amidinophenylmethylsulfonylfluoride, an irreversible serine protease inhibitor selective for substrates with positively charged side chains such as lysine and arginine. It is provided as a high-purity research reagent for enzymology and biochemical assays.
- Irreversible serine protease inhibitor selective for positively charged side chains.
- Provided as the hydrochloride salt to aid solubility in aqueous assays.
- High purity (95.0%) suitable for research and assay development.
- Molecular weight 252.69; formula C8H10ClFN2O2S.
- Offered in small-scale packaging (1 mg) for screening and mechanistic studies.
Medchemexpress LLC Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 25MG
Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 25MG
Medchemexpress LLC PD153035 hydrochloride | 183322-45-4 | 99.5% | 1 ML
PD153035 hydrochloride is a potent ATP-competitive epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor supplied as a ready-to-use DMSO stock solution for biochemical and cell-based research applications.
- Potent EGFR inhibitor with reported Ki = 6 pM and IC50 = 25 pM.
- Supplied as a 10 mM solution in DMSO (1 mL) for convenient dosing in assays.
- High purity suitable for biochemical and cell-based studies.
- CAS number 183322-45-4 for unambiguous identification.
- Molecular weight 396.67 g/mol and formula C16H15BrClN3O2.
- Widely used in kinase signaling and cancer research to block EGFR activity.