Aminophenols
Medchemexpress LLC Iccb-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 1 ML
ICCB-19 hydrochloride is an inhibitor of TRADD (TNFRSF1A associated via death domain). It binds to the N-terminal domain of TRADD (TRADD-N), which prevents TRADD-N from binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride also acts as an indirect inhibitor of RIPK1 kinase activity and effectively induces autophagy and the degradation of long-lived proteins.
- TRADD (TNFRSF1A associated via death domain) inhibitor.
- Binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2.
- Indirect inhibitor of RIPK1 kinase activity.
- Induces autophagy and degradation of long-lived proteins.
- Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM (In Vitro).
- Reduces inflammatory responses in Tradd-/- mice (In Vivo).
eMolecules 101-18-8 | 3-Hydroxydiphenylamine | Combi-Blocks | MFCD00002262 | 185.226 | C12H11NO | 98.000 | Oc1cccc(Nc2ccccc2)c1 | 1g | 290690778
3-Hydroxydiphenylamine | Combi-Blocks | 101-18-8 | MFCD00002262 | 185.226 | C12H11NO | 98.000 | Oc1cccc(Nc2ccccc2)c1 | 1g | 290690778
![eMolecules 86347-15-1 | Medetomidine Hydrochloride | Key Organics/BIONET236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 20mg | 564356420](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000128174.jpg-250.jpg)
eMolecules 86347-15-1 | Medetomidine Hydrochloride | Key Organics/BIONET236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 20mg | 564356420
Medetomidine Hydrochloride | Key Organics/BIONET | 86347-15-1236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 20mg | 564356420
Medchemexpress LLC Ly266097 hydrochloride | 172895-39-5 | MFCD00949080 | >98.0% | 407.33 g·mol⁻¹ | C21H23ClN2O2 · HCl | 25 MG
LY266097 hydrochloride is the hydrochloride salt of LY-266,097, a potent and selective 5-HT2B receptor antagonist used as a research reagent in neuroscience and pharmacology. It is supplied as a crystalline solid, typically at high purity, and is used for receptor binding and functional studies in vitro and in vivo.
- Selective 5-HT2B receptor antagonist for neuroscience research.
- High purity (typically ≥98%) for analytical and biological assays.
- Available as powder or as a 10 mM solution in DMSO, in milligram-scale packs.
- Molecular weight ~407.33 g·mol⁻¹; empirical formula C21H23ClN2O2 · HCl.
- Suited for receptor binding, functional assays, and pharmacology studies.
Medchemexpress LLC ZM39923 hydrochloride | 1021868-92-7 | MFCD04974534 | 99.8% | 367.91 g/mol | C23H26ClNO | 5MG
ZM39923 hydrochloride is a research-grade small molecule that acts primarily as a JAK3 inhibitor (pIC50 = 7.1) and also potently inhibits tissue transglutaminase (TGM2) (IC50 ≈ 10 nM). It displays weaker activity against EGFR and JAK1 and minimal activity versus Lck and CDK4. Supplied as the hydrochloride salt with high reported purity, it is intended for laboratory research use only.
- JAK3 inhibitor with pIC50 7.1.
- Potent tissue transglutaminase (TGM2) inhibition (IC50 ≈ 10 nM).
- Hydrochloride salt form for improved stability and handling.
- High reported purity (around 99.8%).
- Available as solid and as a DMSO solution format.
- Intended for research use only; not for diagnostic or therapeutic use.
Medchemexpress LLC Hypidone hydrochloride | 1339058-04-6 | 99.7% | 334.84 g/mol | C18H23ClN2O2 | 10 MG
Hypidone hydrochloride is the hydrochloride salt of a research compound reported to modulate 5-HT receptors and inhibit serotonin uptake in preclinical studies. It is supplied as a high-purity solid for laboratory use, typically in milligram-scale vials for in vitro and in vivo research.
- High reported purity (>99%).
- Molecular weight 334.84 g/mol.
- Solid hydrochloride salt, white to off-white powder.
- Reported activity as a 5-HT receptor modulator and uptake inhibitor in preclinical models.
- Packaged in small, milligram-scale quantities suitable for research.
Medchemexpress LLC Tas4464 (hydrochloride) | 1848959-11-4 | 98.9% | 25 MG
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It exhibits antiproliferative and cytotoxic effects with broad-spectrum antitumor activity against various hematologic and solid tumor cell lines and patient-derived tumor cells. This compound has a wide therapeutic window without obvious toxicity and is suitable for research in hematologic malignancies and solid tumors.
- Highly potent and selective NAE inhibitor
- Demonstrates broad-spectrum antitumor activity against various cancer models
- Induces tumor cell apoptosis
- Increases protein expression levels of CRL ubiquitin ligase substrates
- Inhibits migratory capacity of solid tumor cell lines
- Achieves complete tumor regression in various animal models
- Prolongs survival and reduces tumor burden in lymphoma models
- Possesses a wide therapeutic window without obvious toxicity
eMolecules 258331-10-1 | TERT-BUTYL 2-(2-HYDROXYPHENYL)ACETATE | AstaTech | MFCD25019077 | 208.257 | C12H16O3 | 95.000 | CC(C)(C)OC(=O)Cc1ccccc1O | 1g | 335884869
TERT-BUTYL 2-(2-HYDROXYPHENYL)ACETATE | AstaTech | 258331-10-1 | MFCD25019077 | 208.257 | C12H16O3 | 95.000 | CC(C)(C)OC(=O)Cc1ccccc1O | 1g | 335884869
Medchemexpress LLC Csrm617 hydrochloride | 1353749-74-2 | 100.0% | 25 MG
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2). It binds the OC2-HOX domain (Kd 7.43 μM in SPR assays), induces apoptosis in preclinical models, and is supplied as a high-purity solid suitable for in vitro and in vivo studies.
- Selective ONECUT2 inhibitor with documented apoptosis induction.
- High purity: 99.97%.
- Available in multiple solid pack sizes including 25 MG.
- Soluble in DMSO: 100 mg/mL; several in vivo formulation protocols provided.
- Storage: solid at -20°C; solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC His-Pro hydrochloride | 2415727-78-3 | 99.8% | 288.73 | 100 MG
His-Pro (Histidyl-proline) hydrochloride is a dipeptide consisting of histidyl and proline. It is for research use only and not sold to patients.
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US
- Storage: Sealed storage, away from moisture and light. Powder: -80°C for 2 years, -20°C for 1 year. In solvent: -80°C for 6 months, -20°C for 1 month.
- Solubility (In Vitro): DMSO: 125 mg/mL (432.93 mM)
Apexbio Technology LLC OTS964 hydrochloride 1338545-07-5 2mg
OTS964 hydrochloride (CAS 1338545-07-5) is a selective inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) demonstrating an IC50 of 28 nM against its target As a dimethylated derivative of OTS514 OTS964 displays high affinity and selectivity for TOPK a serine/threonine kinase implicated in various human malignancies In vitro OTS964 potently suppresses proliferation of multiple TOPK-positive cancer cell lines (IC50 values ranging from 7 6 to 73 nM) while showing markedly reduced activity in TOPK-negative models In in vivo studies OTS964 administered intravenously to mice bearing LU-99 xenografts resulted in significant tumor growth inhibition without notable toxicity Research applications include studying TOPK-related oncogenic pathways and hematopoietic cell differentiation
Medchemexpress LLC Ac-099 hydrochloride | 849335-07-5 | 99.9% | 301.10 g/mol | C9H9Cl2F3N4 | 10 MG
AC-099 hydrochloride is a research-grade small-molecule hydrochloride salt used in preclinical studies as a ligand for neuropeptide FF receptors. The compound is supplied as a solid and characterized by standard analytical data for laboratory use.
- Research use only; not for human or veterinary use.
- High reported purity, 99.9%.
- Chemical formula C9H9Cl2F3N4 and molecular weight 301.10 g/mol.
- Provided as a solid suitable for dissolution in common organic solvents.
- Common applications include receptor pharmacology and in vivo preclinical assays.
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | 99.9% | 163.60 g·mol⁻¹ | C6H10ClNO2 | 100 MG
Guvacine hydrochloride is a research reagent used to inhibit GABA uptake in neuropharmacology and biochemical studies. It is supplied as a white to off-white solid and is available in both solid and small-solution formats for in vitro experiments.
- Functions as a GABA uptake inhibitor for neuropharmacology research.
- High purity (~99.9%) minimizes impurities in assays.
- Available as solids and as a DMSO solution for experimental flexibility.
- White to off-white solid suitable for analytical and in vitro use.
- Molecular weight 163.60 g·mol⁻¹ supports accurate stoichiometry calculations.
Medchemexpress LLC V-0219 hydrochloride | 2922283-73-4 | MFCD35062234 | 99.4% | 446.89 g/mol | C20H26ClF3N4O2 | 5 MG
V-0219 hydrochloride is the hydrochloride salt of an orally active positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It is supplied as a solid research reagent for in vitro and preclinical studies of GLP-1R modulation and metabolic disease models.
- High purity (99.39%) for reproducible experimental results.
- Solid form, convenient to weigh and store.
- Good DMSO solubility (100 mg/mL) for assay preparation.
- Suitable for in vitro and preclinical screening applications.
- Storage guidance provided for sealed, moisture-free conditions and solvent storage at -80 °C (long term) or -20 °C (short term).
Medchemexpress LLC LYN-1604 hydrochloride | 2216753-86-3 | MFCD31630830 | >98.0%
LYN-1604 hydrochloride | 2216753-86-3 | MFCD31630830 | >98.0%