Aminophenols
Medchemexpress LLC L-NAME (hydrochloride) | 51298-62-5 | 99.9% | 269.69 | 10MM/1ML
L-NAME hydrochloride inhibits nitric oxide synthase (NOS) with an IC50 of 70 μM. This compound acts as a precursor to the NOS inhibitor L-NOARG, which demonstrates an IC50 value of 1.4 μM. It is intended for research use only and is not sold for patient use.
- Inhibits nitric oxide synthase activity.
- Functions as a precursor for a more potent NOS inhibitor.
- Utilized in the induction of hypertension models in research.
- Can be used to induce preeclampsia models.
- High purity of 99.89% ensures reliable experimental results.
Medchemexpress LLC Acetaminophen (Paracetamol) | 103-90-2 | MFCD00002328 | 99.97% | C8H9NO2 | 500 MG
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM. It is widely used as an antipyretic and analgesic agent. It has also been identified as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor and can induce ferroptosis, leading to acute liver injury in a mice model.
- Selective cyclooxygenase-2 (COX-2) inhibitor
- Functions as an antipyretic and analgesic agent
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
Medchemexpress LLC Axc-715 hydrochloride | 2490497-93-1 | 99.5% | 347.89 g/mol | C18H26ClN5 | 5 MG
AXC-715 hydrochloride is the hydrochloride salt of a small-molecule TLR7/TLR8 dual agonist used in preclinical research as an immunostimulant and as a building block for antibody-adjuvant immunoconjugates. It is supplied as a high-purity solid suitable for in vitro and in vivo studies, with recommended storage conditions to maintain stability.
Medchemexpress LLC SKI V | 24418-86-8 | 99.0% | 100 MG
SKI V is a potent, noncompetitive non-lipid sphingosine kinase (SPHK) inhibitor with an IC50 of 2 μM for GST-hSK. It also inhibits PI3K with an IC50 of 6 μM. This compound reduces the formation of sphingosine-1-phosphate (S1P), induces apoptosis, and demonstrates antitumor activity. It appears as a light yellow to yellow solid.
- Potently inhibits sphingosine kinase (SPHK)
- Inhibits PI3K
- Reduces sphingosine-1-phosphate (S1P) formation
- Induces apoptosis
- Exhibits antitumor activity
- Weak activity towards ERK2
- Does not inhibit PKC-α
Medchemexpress LLC NPS-2143 hydrochloride | 324523-20-8 | MFCD04113010 | 100.0% | 445.38 | C24H26Cl2N2O2 | 1 ML
NPS-2143 hydrochloride is a selective and potent calcium-sensing receptor (CaSR) antagonist used as a calcilytic research tool to modulate intracellular calcium signaling and parathyroid hormone secretion. It is supplied as a white to off-white solid and is available pre-formulated as a 10 mM solution in DMSO for laboratory use.
- Selective calcium-sensing receptor antagonist (IC50 = 43 nM).
- Useful for studies of CaSR signaling and parathyroid hormone release.
- Available as solid and as a 10 mM solution in DMSO for convenience.
- High purity suitable for research applications.
- White to off-white solid form for easy handling and storage.
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 1 ML
AT7519 Hydrochloride is a potent inhibitor of cyclin-dependent kinases (CDKs), with low nanomolar IC50s for CDK1, CDK2, CDK4-CDK6, and CDK9. It induces cytotoxicity and apoptosis in multiple myeloma (MM) cells, linked to GSK-3β activation and inhibition of RNA polymerase II. The compound inhibits tumor growth in MM xenograft mouse models and has been involved in clinical trials for various cancers.
- Potent inhibitor of CDKs (CDK1, CDK2, CDK4-CDK6, CDK9)
- Induces cytotoxicity and apoptosis in MM cells
- Overcomes cytokine and BMSC protective effects
- Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
- Inhibits cell cycle progression and reduces antiapoptotic protein levels
- Inhibits tumor growth in MM xenograft mouse models
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | 98.5% | 280.75 | C14H17ClN2O2 | 10 MG
Imiloxan hydrochloride is a potent, selective α2B-adrenoceptor antagonist used in pharmacology research to probe adrenergic receptor subtype function. It is used in both in vitro receptor assays and in vivo models to study antagonist activity and physiological responses such as mydriasis reversal.
- Selective α2B-adrenoceptor antagonist.
- High purity suitable for research use.
- Molecular weight 280.75 g·mol⁻¹.
- Available in small, precise research quantities.
- Applicable to in vitro assays and in vivo pharmacology models.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 2 MG
SR9011 hydrochloride is a potent REV-ERBα/β agonist (IC50s: 790 nM for REV-ERBα, 560 nM for REV-ERBβ). It significantly increases REV-ERB-dependent repressor activity and suppresses transcription via full-length REV-ERBα. The compound inhibits BMAL1 mRNA expression in HepG2 cells and suppresses breast cancer cell proliferation by halting the cell cycle before M phase. In mice, SR9011 suppresses REV-ERB responsive genes and temporarily reduces locomotor activity during the dark phase.
- Potent REV-ERBα/β agonist.
- Increases REV-ERB-dependent repressor activity.
- Suppresses transcription via full-length REV-ERBα.
- Inhibits BMAL1 mRNA expression in HepG2 cells.
- Suppresses breast cancer cell proliferation.
- Pauses cell cycle prior to M phase, increasing G0/G1 phase cells.
- Suppresses REV-ERB responsive genes in mice.
- Reduces locomotor activity in mice under dark conditions.
Medchemexpress LLC LDC4297 (hydrochloride) | 2319747-14-1 | 98.2% | 25 MG
LDC4297 hydrochloride is a selective inhibitor of CDK7, effectively inhibiting human cytomegalovirus (HCMV) replication. It exhibits broad antiviral activities against various virus families including Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae. This compound is suitable for infection research.
- Selective inhibitor of CDK7
- Inhibits human cytomegalovirus (HCMV) replication
- Demonstrates broad antiviral activities against multiple virus families
- Useful for infection research
- Solid form storage: 4°C, sealed, away from moisture and light
- In-solvent storage: -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light
Medchemexpress LLC AC-099 (hydrochloride) | 849335-07-5 | C9H9Cl2F3N4 | 5 MG
AC-099 hydrochloride is a chemical compound primarily used in laboratory settings and for the manufacture of various substances. It is identified by its CAS number 849335-07-5 and has a chemical formula of C9H9Cl2F3N4.
- Keep container tightly sealed in cool, well-ventilated area.
- Store away from direct sunlight and sources of ignition.
- Powder stability: 3 years at -20°C, 2 years at 4°C.
- Stability in solvent: 6 months at -80°C.
- Stable under recommended storage conditions.
Medchemexpress LLC GSK 690 Hydrochlorid 100mg | 2436760-79-9 | 405.92 | C24H24ClN3O | 100 MG
GSK 690 hydrochloride is a reversible small-molecule inhibitor of lysine-specific demethylase 1 (LSD1) with a reported Kd of 9 nM and a biochemical IC50 of 37 nM. It is supplied as a light yellow to yellow solid (CAS 2436760-79-9) with reported purity of 98.58% and high solubility in DMSO.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 98.97% | 515.50 | 100 MG
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is for research use only.
- Increases REV-ERB-dependent repressor activity.
- Suppresses proliferation of breast cancer cell lines, regardless of ER or HER2 status.
- Causes cell cycle arrest prior to M phase by suppressing Cyclin A (CCNA2).
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
- Displays reasonable plasma exposure in vivo.
Medchemexpress LLC Fasudil hydrochloride | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g/mol | C14H18ClN3O2S | 10 G
Fasudil hydrochloride is the hydrochloride salt of fasudil, a small-molecule inhibitor of RhoA/ROCK kinases used in biochemical and cell-based research. It is supplied for analytical and research applications and is typically handled as a solid powder with known solubility in DMSO and water.
Medchemexpress LLC P-amidinophenylmethylsulfonylfluoride hydrochloride | 74938-88-8 | MFCD00078902 | 95.0% | 252.69 | C8H10ClFN2O2S | 1 MG
p-APMSF hydrochloride is the hydrochloride salt of p-amidinophenylmethylsulfonylfluoride, an irreversible serine protease inhibitor selective for substrates with positively charged side chains such as lysine and arginine. It is provided as a high-purity research reagent for enzymology and biochemical assays.
- Irreversible serine protease inhibitor selective for positively charged side chains.
- Provided as the hydrochloride salt to aid solubility in aqueous assays.
- High purity (95.0%) suitable for research and assay development.
- Molecular weight 252.69; formula C8H10ClFN2O2S.
- Offered in small-scale packaging (1 mg) for screening and mechanistic studies.
Medchemexpress LLC Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 25MG
Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 25MG