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Filtered Search Results
Medchemexpress LLC Pravastatin (sodium) | 81131-70-6 | 99.0% | 5 G
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Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with an IC50 of 5.6 μM. It is a statin used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.
- Inhibits HMG-CoA reductase.
- For research use only.
- IC50 for inhibiting cellular steroidogenesis in HepG2 hepatocytes is 1.37 μM.
- IC50 for antimalarial activity against Plasmodium berghei NK65 in HepG2 hepatocytes is > 200 μM (after 48 hours by RT-PCR).
- Inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 of 0.1 μM.
- Inhibits cholesterol synthesis from [14C]- Acetate in hepatocytes of rats with an IC50 of 100 nM.
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Medchemexpress LLC Niacin (standard) | 59-67-6 | 25 G
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Niacin (Vitamin B3) is an orally active, water-soluble B3 vitamin that is an essential nutrient for humans. It plays a key role in energy metabolism, cell signaling cascades regulating gene expression, and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases. This product is intended for research and analytical applications. It is stable under recommended storage conditions.
- Orally active and water-soluble B3 vitamin
- Essential nutrient for humans
- Key role in energy metabolism
- Involved in cell signaling cascades regulating gene expression and apoptosis
- Used in the study of cardiovascular diseases
- Intended for research and analytical applications
- Stable under recommended storage conditions
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Medchemexpress LLC Nizatidine | 76963-41-2 | 98.7% | 25 G
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Nizatidine is a potent and orally active histamine H2 receptor antagonist. It is used in research for stomach and intestine ulcers, functioning by decreasing gastric acid secretion and preventing ulcer recurrence in animal models.
- Potent and orally active histamine H2 receptor antagonist
- Decreases gastric acid secretion
- Prevents ulcer recurrence after healing in animal models
- Molecular weight: 331.46
- Formula: C12H21N5O2S2
- Appearance: Solid
- Color: White to off-white
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 2 years, -20°C for 1 year
- Melting/freezing point: 130–132°C
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Medchemexpress LLC Ethambutol dihydrochloride | 1070-11-7 | 99.9% | 1 ML
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Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. It is also used to establish animal models of hyperuricemia and optic neuropathy.
- Antimycobacterial compound
- Inhibits arabinosyltransferase activity
- Purity of 99.9%
- Used in hyperuricemia animal models
- Used in optic neuropathy animal models
- Solid, white to off-white appearance
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Medchemexpress LLC Cyanoacetohydrazide | 140-87-4 | 99.7% | 25 G
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Cyanoacetohydrazide is a pharmaceutical intermediate. It can be used to synthesize acylhydrazide hydrazone derivatives with antibacterial or anti-tumor activity.
- Molecular weight of 99.09
- Chemical formula: C3H5N3O
- Appears as a solid
- Color ranges from light yellow to light brown
- Solid storage at 4°C, sealed, away from moisture
- Solvent storage at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture
- Soluble in DMSO at 100 mg/mL
- Soluble in water at 100 mg/mL
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Medchemexpress LLC Amantadine | 768-94-5 | 99.9% | 100 G
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Amantadine is an orally active and potent antiviral agent effective against influenza A viruses and coronaviruses. It inhibits various ion channels, including NMDA and M2, and shows anti-orthopoxvirus and anticancer activities. This compound is suitable for research applications related to Parkinson's disease, postoperative cognitive dysfunction, and COVID-19.
- Inhibits influenza A viruses and coronavirus ion channels
- Demonstrates anti-orthopoxvirus and anticancer activity
- Suitable for research on Parkinson's disease and COVID-19
- Inhibits SARS-CoV-2 replication in Vero E6 cells
- Markedly inhibits proliferation of HepG2 and SMMC 7721 cells
- Arrests cell cycle at G0/G1 phase and induces apoptosis
- Reduces cyclin D1, cyclin E, and CDK2 levels
- Increases Bax protein and mRNA levels while decreasing Bcl-2
- Inhibits surgery-induced neuroinflammation and learning impairment in rats
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Medchemexpress LLC Pregnenolone (3β-Hydroxy-5-pregnen-20-one) | 145-13-1 | >99.9% | 25 G
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Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a potent neurosteroid and the primary precursor for various steroid hormones, including steroid ketones. It functions as a signaling-specific inhibitor of the cannabinoid CB1 receptor, thereby inhibiting the effects of tetrahydrocannabinol (THC) that are mediated by CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Additionally, it acts as a TRPM3 channel activator and can weakly activate TRPM1 channels.
- Potent neurosteroid
- Primary precursor for various steroid hormones
- Signaling-specific inhibitor of CB1 receptor
- Inhibits THC effects mediated by CB1 receptors
- Protects the brain from cannabis intoxication
- Acts as a TRPM3 channel activator
- Weakly activates TRPM1 channels
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Medchemexpress LLC Sulfameter | 651-06-9 | 99.9% | 25 G
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Sulfameter (Sulfametoxydiazine) is an orally active, long-acting sulfonamide antibiotic. It exhibits activity against both Gram-positive and Gram-negative bacteria, making it suitable for research into diseases such as respiratory and urinary tract infections.
- Orally active, long-acting sulfonamide antibiotic
- Active against Gram-positive bacteria
- Active against Gram-negative bacteria
- Used for research of respiratory tract infections
- Used for research of urinary tract infections
- Forms a complex with silver, showing activity against S. aureus, E. coli, and P. aeruginosa
- More active against Gram-negative bacteria when complexed with silver
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Medchemexpress LLC Anethole | 104-46-1 | 98.9% | 25 G
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Anethole is an orally active aromatic compound found widely in nature, primarily used as a flavoring agent. It demonstrates a range of biological effects, including anticancer, anti-inflammatory, antioxidant, and antimicrobial properties. It is also noted for its anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective activities. This product is for research use only.
- Exhibits anticancer properties
- Anti-inflammatory effects
- Antioxidant activity
- Antibacterial and antifungal properties
- Anesthetic and hypnotic effects
- Central nervous system depressant
- Gastroprotective properties
- Used in studies related to oxidative stress-related skin diseases
- Applicable in prostate cancer research
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Medchemexpress LLC Cyanoacetohydrazide | 140-87-4 | MFCD00007611 | 99.7% | 100 G
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Cyanoacetohydrazide is a pharmaceutical intermediate that can be used to synthesize acylhydrazide hydrazone derivatives with antibacterial or anti-tumor activity.
- Solid appearance
- Color ranges from light yellow to light brown
- Molecular weight of 99.09
- Molecular formula C3H5N3O
- Soluble in DMSO and H2O (100 mg/mL)
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Medchemexpress LLC Ethambutol dihydrochloride | 1070-11-7 | 99.9% | 100 MG
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Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. It can be used to establish animal models of hyperuricemia and optic neuropathy.
- Prevents cell wall formation by inhibiting arabinosyltransferase activity.
- Can be used to establish animal models of hyperuricemia.
- Can be used to establish animal models of optic neuropathy.
- Increases uric acid levels by reducing renal uric acid clearance in hyperuricemia models.
- Induction of hyperuricemia is often combined with adenine for better model construction.
- Induction of optic neuropathy involves oral administration at specific doses and durations.
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Medchemexpress LLC Ethambutol dihydrochloride | 1070-11-7 | 99.9% | 5 G
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Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. It can be used to establish animal models of hyperuricemia and optic neuropathy.
- Antimycobacterial compound
- Prevents cell wall formation
- Inhibits arabinosyltransferase activity
- Used to establish animal models of hyperuricemia
- Used to establish animal models of optic neuropathy
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Medchemexpress LLC Allylthiourea (Thiosinamine) | 109-57-9 | 99.95% | 100 G
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Allylthiourea can selectively inhibit the oxidation of ammonia. It is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. It can be utilized in research related to micropollutant biodegradability and cancer studies.
- Selectively inhibits ammonia oxidizers.
- Decreases intracellular copper in *Methylosinus trichosporium* OB3b.
- Used to inhibit nitrification by targeting ammonia monooxygenase.
- Exhibits cytotoxicity against MCF-7 cell line.
- Useful for micropollutant biodegradability and cancer studies.
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Medchemexpress LLC Bucladesine sodium (Dibutyryl cAMP sodium salt) | 16980-89-5 | 99.4% | 5 G
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Bucladesine sodium salt, also known as Dibutyryl-cAMP sodium salt, is a stabilized cyclic AMP (cAMP) analog. It acts as a selective PKA activator and increases intracellular cAMP levels. This compound also functions as a phosphodiesterase (PDE) inhibitor, exhibiting anti-inflammatory activity and is utilized for its role in promoting wound healing.
- Acts as a stabilized cyclic AMP (cAMP) analog
- Functions as a selective PKA activator
- Increases intracellular cAMP levels
- Acts as a phosphodiesterase (PDE) inhibitor
- Exhibits anti-inflammatory activity
- Used for impaired wound healing
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Medchemexpress LLC Cloxacillin sodium monohydrate | 7081-44-9 | 99.4% | 10 G
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Cloxacillin sodium monohydrate is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. It suppresses the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-κB, and NLRP3-related proteins. It is for research use only.
- Orally active antibacterial agent and β-lactamase inhibitor.
- Effective against S. aureus 8325-4 and DU1090 with MIC values of 0.125 μg/mL.
- Inhibits hemolytic activity of Hlα in vitro.
- Protects against S. aureus peritonitis in vivo when combined with Thioridazine and Tetracycline.
- Reduces synovitis and bone erosions in systemic S. aureus-induced arthritis model when combined with anti-IL-15 antibodies.
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