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Filtered Search Results
Medchemexpress LLC 17-allylamino-17-demethoxygeldanamycin | 75747-14-7 | MFCD04973892 | 99.0% | 585.69 g/mol | C31H43N3O8 | 200 MG
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Tanespimycin (17-AAG) is a benzoquinone-derived HSP90 inhibitor used as a research tool in cellular and biochemical studies of HSP90-dependent signaling and oncology models. It displays low-nanomolar potency against HSP90 and is provided in multiple pack formats for laboratory use.
- Potent HSP90 inhibitor with an IC50 of 5 nM.
- Preferential binding to tumor-derived HSP90 compared with normal HSP90.
- Purity 99.01% as supplied.
- Molecular formula C31H43N3O8; molecular weight 585.69 g/mol.
- CAS number 75747-14-7.
- Available as solid and solution formats, including a 200 mg pack.
- Store protected from light; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
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Medchemexpress LLC HY-107419 5mg Medchemexpress, NU6140 CAS:444723-13-1 Purity:>98%
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Medchemexpress, HY-107419 5mg NU6140 CAS:444723-13-1 NU6140 is a selective CDK2-cyclin A inhibitor ( IC 50 , 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs [1] . NU6140 also potently inhibits Aurora A and Aurora B , with IC 50 s of 67 and 35 nM, respectively [2] . Enhances the apoptotic effect, with anti-cancer activity [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-107765 5mg Medchemexpress, LY2955303 CAS:1433497-19-8 Purity:>98%
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Medchemexpress, HY-107765 5mg LY2955303 CAS:1433497-19-8 LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Sigma Aldrich Fine Chemicals Biosciences Vancomycin hydrochloride from Streptomyces orientalis meets USP testing specifications | 1404-93-9 | 1G
Vancomycin hydrochloride from Streptomyces orientalis meets USP testing specifications | Mol Wt: 1485.71 | 1404-93-9 | 1G
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Medchemexpress LLC HZX-02-059 | 2240205-30-3 | 99.4% | 487.48 | 50 MG
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HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. Methuosis primarily disrupts the balance of endocytosis and exocytosis, leading to the formation of numerous vesicles and inducing cell death. This compound also induces cell vacuolization, promotes apoptosis, downregulates the p53 pathway, inhibits PI3K/AKT phosphorylation, and inhibits c-Myc and NF-κB transcription.
- Potent methuosis inducer
- Dual-target PIKfyve/tubulin inhibitor
- Anticancer activity
- Induces cell vacuolization
- Promotes apoptosis
- Downregulates the p53 pathway
- Inhibits PI3K/AKT phosphorylation
- Inhibits c-Myc and NF-κB transcription
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eMolecules 32502-62-8 | Medchem Express | 3-Methyltoxoflavin | 5mg | 446259918 | HY-111117 | MFCD00449892 | 207.193 | C8H9N5O2
Medchem Express | Garcinol | 1mg | 495799608 | HY-107569 | 78824-30-3 | MFCD03700761 | 602.812 | C38H50O6
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Medchemexpress LLC Carboxyamidotriazole Orotate | 187739-60-2 | 99.7% | 580.76 | 5 MG
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Carboxyamidotriazole Orotate is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. It functions as a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. This product demonstrates anti-tumor, anti-inflammatory, and antiangiogenic effects.
- Functions as a cytostatic inhibitor of nonvoltage-operated calcium channels.
- Inhibits calcium channel-mediated signaling pathways.
- Exhibits anti-tumor effects.
- Exhibits anti-inflammatory effects.
- Exhibits antiangiogenic effects.
- Inhibits cell proliferation of LAMA84R and K562R cell lines.
- Reduces phosphorylation of CrkL.
- Shows dose-dependent inhibition of total and phosphorylated Bcr-Abl levels.
- Displays antitumor activity on CML xenografts.
- Increased survival in animal models.
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Medchemexpress LLC HY-103361 5mg Medchemexpress, SB297006 CAS:58816-69-6 Purity:>98%
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Medchemexpress, HY-103361 5mg SB297006 CAS:58816-69-6 SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Cdk9-in-13 (compound 38) | 2768712-71-4 | MFCD11162707 | 99.9% | C27H35N5O2 | 10MG
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CDK9-IN-13 is a research small-molecule inhibitor selective for cyclin-dependent kinase 9 (CDK9). Reported as compound 38, it inhibits CDK9 with an IC50 of <3 nM and has been characterized in preclinical rodent studies where it exhibits short in vivo half-lives. Intended for in vitro and early preclinical research use only.
- Potent CDK9 inhibition with IC50 <3 nM.
- Selective activity toward CDK9 for target validation studies.
- High supplied purity (≈99.94%), limiting impurity-related variability.
- Defined molecular properties (C27H35N5O2; MW 461.60 g·mol⁻1).
- Offered in multiple small-scale quantities suitable for preclinical experiments.
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Medchemexpress LLC HY-100034 25mg Medchemexpress, NSC 663284 CAS:383907-43-5 Purity:>98%
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Medchemexpress, HY-100034 25mg NSC 663284 CAS:383907-43-5 NSC 663284 is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC 50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-101490 5mg Medchemexpress, PDE1-IN-2 CAS:1904611-63-7 Purity:>98%
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Medchemexpress, HY-101490 5mg PDE1-IN-2 CAS:1904611-63-7 PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC 50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-15555 5mg Medchemexpress, EPZ005687 CAS:1396772-26-1 Purity:>98%
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Medchemexpress, HY-15555 5mg EPZ005687 CAS:1396772-26-1 EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-13328 10mg Medchemexpress, Sapanisertib CAS:1224844-38-5 Purity:>98%
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Medchemexpress, HY-13328 10mg Sapanisertib CAS:1224844-38-5 Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Apexbio Technology LLC Spironolactone 52-01-7 100mg
Spironolactone (52-01-7) is a small-molecule antagonist targeting mineralocorticoid (aldosterone) and androgen receptors It is designed to block receptor-mediated signaling thereby affecting sodium and potassium balance and pathways related to androgen signaling Spironolactone exerts its biological activity primarily through competitive inhibition of mineralocorticoid and androgen receptors In in vitro studies spironolactone demonstrates antagonistic activity with an IC50 value of 24 nM for mineralocorticoid receptors and 77 nM for androgen receptors Based on these pharmacological properties spironolactone holds research potential in studies of hormone signaling sodium homeostasis and androgen receptor-mediated gene expression in endocrine or cancer research
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Medchemexpress LLC HY-114180 5mg Medchemexpress, RU.521 CAS:2262452-06-0 Purity:>98%
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Medchemexpress, HY-114180 5mg RU.521 CAS:2262452-06-0 RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC 50 of 700 nM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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