Cayman Chemical Cheldonn 10mg
An NSAID and COX inhibitor (IC50s 3 and 9.3 UM for human COX-1 and COX-2 respectively) inhibits TNF-a-induced increases in COX-2 levels and NF-KB activation in HT-29 colon cancer cells in a concentration-dependent manner inhibits fMLP- or A23187-induced calcium influx in PMN (IC50s 29 and 14 UM respectively) activates various ion channels including TRPC6 and KCa1.1 inhibits various ion channels including TRPC3 and CFTR reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae at 20 mg/kg