Custom Peptides
Cayman Chemical DMAPPamonIum salt 10mg
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Cayman Chemical MEGsulfate 10mg
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Cayman Chemical TaurocholIc AcId 3sulfatS 10mg
A metabolite of taurocholic acid; plasma levels are elevated in wild-type and Sort1 knockout mice at 6 hours post-BDL and are further elevated in Sort1 knockout mice at 24 hours post-BDL
Cayman Chemical 1Ohexadecyl2Docosahexaeno 10mg
1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC is a PAF analog which contains docosahexaenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. 1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC can be oxidatively fragmented resulting in the production of phospholipids with PAF-like activity.{1938,2654}
Cayman Chemical DIhomoLInolenIc ACD ethyl 10mg
An ester form of DGLA; dietary administration of ethyl DGLA at 1 g/kg per day increases PGE1 and PGE2 secretion in rabbit renal papilla; increases triglyceride levels and the proportion of 20:3ω6 and 20:4ω6 phospholipids of the renal medulla in rabbits
Cayman Chemical mthyl lnolnyl Fluorophos 10mg
An analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.
Cayman Chemical 4chloroaCynocInamIc AcId 10mg
A phenylpropanoid which readily co-crystallizes with various biomolecules
Cayman Chemical AdrenIc AcId 10mg
A naturally occurring PUFA formed through a 2-carbon chain elongation of arachidonic acid; present in the adrenal glands, brain, testis, and kidney
Cayman Chemical GunfacInhydrochlorIde 10mg
An α2-AR agonist (Kis = 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively); EC50s = 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively for stimulated [35S]GTPγS binding; Ki = 19 nM for imidazoline receptor 1; lowers blood pressure in hypertensive rats in a dose-dependent manner when administered at a dose of 0.3-5 mg/kg; improves spatial working memory deficits induced by hypobaric hypoxia in rats
Cayman Chemical SclerotIorIn 10mg
A natural product that inhibits soybean LO-1 (IC50 = 4.2 µM), cholesterol ester transfer protein (IC50 = 19.4 µM), Grb2-Shc interaction (IC50 = 22 µM), and antagonizes endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively)
Cayman Chemical Petromyzonl 10mg
Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate ester (petromyzonol sulfate) is a pheromone and a spawning chemoattractant which can be detected at very low concentrations by lamprey olfactory chemoreceptors. Petromyzonol, petromyzonol sulfate, and allocholic acid are all found in water samples from fresh water streams bearing larval lamprey populations.{7478}
Cayman Chemical NAcetylagmatInacetAT sal 10mg
A potential monoacetylated derivative of the natural polyamine agmatine
Cayman Chemical Latnoprost Lacton DIol 10mg
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactone diol is an intermediate in the synthesis of latanoprost. Latanoprost lactone diol can be converted to the free acid of latanoprost by reduction with DIBAL followed by Wittig reaction with commercially available reagents.
Cayman Chemical EIcosapentaenoyl SRotonIn 10mg
A hybrid molecule patterned after arachidonoyl serotonin; the biological effects of eicosapentaenoyl serotonin are unknown
Cayman Chemical AtIpamezolehydrochlorIde 10mg
An α2A-AR antagonist (Ki = 1.86 nM); selective for α2A-ARs over α2B- and α1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM); reverses medetomidine-induced bradycardia and sedation in dogs at 0.04, 0.08, and 1.2 mg/kg; enhances apomorphine- or L-DOPA-induced contralateral circling behavior and prolongs the duration of action of L-DOPA in a rat model of Parkinson’s disease at 0.3 mg/kg