Custom Peptides
Cayman Chemical NBI 35965mesylate 10mg
A selective CRF1 antagonist (Ki = 4 nM); inhibits cAMP accumulation and ACTH production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo
Cayman Chemical CIraparntagtrIfluoroACTAt 10mg
An anticoagulant reversal agent; selectively binds to unfractionated heparin, enoxaparin, and Factor IXa (Kds = 28, 17, and 35 µM, respectively) over edoxaban, rivaroxaban, Factor Xa, Factor IX, thrombin, antithrombin, and fibrinogen, and only weakly binds to an enoxaparin-antithrombin complex and fondaparinux (Kds = 690 and 9,600 µM, respectively), in cell-free assays; prevents edoxaban-induced decreases in fibrin diameter in isolated human whole blood at 200 UG/ml; reduces edoxaban-, dabigatran-, apixaban-, rivaroxaban-, unfractionated heparin-, or enoxaparin-stimulated increases in tail transection-induced blood loss in rats
Cayman Chemical 3-keto SphngnInd18 0h 10mg
An intermediate in the biosynthesis of C18 ceramide; a lyso-sphingolipid formed by the condensation of L-serine and palmitoyl-CoA by SPT; vitamin K deficiency decreases production by SPT
Cayman Chemical MItochonIc AcId 5 10mg
An inhibitor of mitochondrial dysfunction; increases intracellular ATP levels in Hep3B cells at a 3 µM; rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells at 5 µM; protects against BSO-induced decreases in cell viability in fibroblasts isolated from patients with various mitochondrial diseases (EC50s = 2.3-5.1 µM) in an electron transport chain-independent manner; reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury at 50 mg/kg
Cayman Chemical ImetIthydrobromIde 10mg
A histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays); selective for histamine H3 and H4 receptors over H1 and H2 receptors when used at 100 µM, as well as 5-HT3 (Ki = 240 nM); reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM); increases scratching in mice (ED50 = 0.9 µmol)
Cayman Chemical Lpofermat 10mg
An inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells); inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM); inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of ROS and reverses decreases in GSH levels induced by palmitate in HepG2 and INS-1E cells; inhibits absorption of 13C-oleate in mice at 500 mg/kg
Cayman Chemical 1PalmItoyl2ArachIdonylsn 10mg
A phospholipid; has been found in egg yolk and isolated rat retina
Cayman Chemical zngbr offIcnle 6Gngerol 10mg
A natural chemical found in fresh ginger that activates TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM)
Cayman Chemical SwertIamarIn 10mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day
Cayman Chemical NacetylSfarnsylLCysteIn 10mg
AFC is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).{2306,2304} Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.
Cayman Chemical Uncaa yncopyla sutn 10mg
An indole alkaloid; reduces glutamate-induced cytotoxicity in primary rat cerebellar granule neurons from 100-300 µM; inhibits nicotine-induced dopamine release in PC12 cells from 1-100 µM
Cayman Chemical TG11-77hydrochlorIde 10mg
An EP2 receptor antagonist (KB = 9.7 nM); selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively); inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors at 0.3 and 1 μM
Cayman Chemical N-ArachIdonyl DopamIn 10mg
An arachidonoyl amino acid and CB1 receptor agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors); selective for CB1 over CB2 receptors (Ki = 12,000 nM in rat spleen membranes, which highly express CB2 receptors); induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM); inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM); induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice at 10 mg/kg
Cayman Chemical SDesoxyD2PMhydrochLRId 10mg
Most commonly used as a chiral solvating agent for NMR analysis of chiral compounds; structurally related to desoxypipradrol, a dopamine transporter inhibitor and psychoactive stimulant
Cayman Chemical GentIopIcrIn 10mg
An iridoid glycoside with diverse biological activities; attenuates ANIT-induced acute cholestasis and liver damage and reverses bile acid dyshomeostasis in mice at 130 mg/kg; increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice at 25, 50, and 100 mg/kg; decreases NMDA receptor-mediated EPSCs in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice at 100 mg/kg