Custom Peptides
Cayman Chemical ByakngelIcol 10mg
A furanocoumarin with diverse biological activities; inhibits AChE and BChE (IC50s = 46.3 and 45.2 µM, respectively); inhibits LPS-induced production of NO in RAW 264.7 cells (IC50 = 16.9 UG/ml) and IL-1β-induced COX-2 activity and PGE2 release in A549 cells from 10-50 µM; reduces tacrine-induced cytotoxicity in HepG2 cells (EC50 = 36.6 µM)
Cayman Chemical N-LIthocholyl-L-LeucIn 10mg
A bile acid conjugate; has been used in the formation of hydrogels
Cayman Chemical RPramIpexolehydrochLRId 10mg
An enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist; an antioxidant that targets mitochondria to prevent apoptosis
Cayman Chemical LCysteInglutathIon dIsulf 10mg
A glutathione derivative endogenous to mammalian cells that is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine; protects mice against acetaminophen-induced hepatotoxicity
Cayman Chemical PalmItyl TrIfluMTYL Keto 10mg
PTK is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. In P388D1 cells, PTK inhibits iPLA2 activity with an IC50 value of 3.8 µM.{1291} A related compound, ATK is a less potent inhibitor of iPLA2 with an IC50 value of 15 µM.{1291} PTK also inhibits the activity of cPLA2 with an IC50 value almost identical to that of ATK.{2992}
Cayman Chemical 2-ThIothInonhydrochlorIde 10mg
An analytical reference standard categorized as a thiophene; intended for research and forensic applications
Cayman Chemical 25C-NBOHhydrochlorIde 10mg
A derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine; a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively); intended for forensic and research applications
Cayman Chemical 7 8-dIhydro-L-BIopterIn 10mg
BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 µM.{1268}
Cayman Chemical Asprgls fumIgatus Fumagln 10mg
A fungal metabolite with diverse biological activities; inhibits METAP2 (IC50 = 10 nM); inhibits tube formation in a rat blood vessel organ culture assay at 10 ng/ml; inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells at 5 UG/ml; decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma at 30 mg/kg; reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity
Cayman Chemical RN-1hydrochlorIde 10mg
A potent, irreversible inhibitor of LSD1 (IC50 = 70 nM); penetrates the blood-brain barrier and blocks long-term but not short-term memory in mice
Cayman Chemical GSK106hydrochlorIde 10mg
An inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 (IC50s >100 µM)
Cayman Chemical 7DIethylamIno3 4maleImIdo 10mg
A thiol-reactive fluorescent probe; fluorescence intensity increases when bound to cysteine residues ; ex/em = 387/468, respectively
Cayman Chemical 15 R-ProstaglndIn F2a 10mg
15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Compared to PGF2α, 15(R)-PGF2α has a binding affinity of 6.7% to ovine luteal cell receptors. Similarly, the binding affinity to rat vascular smooth muscle cells is negligible as compared to PGF2α.
Cayman Chemical GnoderenIc AcId D 10mg
A triterpenoid with diverse biological activities; inhibits ACE (IC50 = 734 µM); cytotoxic to HepG2, HeLa, and Caco-2 cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively); inhibits LPS-induced NO production in BV-2 microglia (IC50 = 13.77 µM)