Custom Peptides
Cayman Chemical S-DuloxetInhydrochlorIde 10mg
A serotonin and norepinephrine reuptake inhibitor (Kis = 4.6 and 15.6 nM, respectively); also inhibits dopamine reuptake (Ki = 369 nM); suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 UG/kg, respectively); has antidepressant-like activity in mice in the forced swim test at 16 and 32 mg/kg
Cayman Chemical 4QuInoLN3CarboxamIde Fur 10mg
A high-affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10,000 nM); demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630
Cayman Chemical Olmesartn MedoxomIl 10mg
A prodrug form of olmesartan; inhibits the angiotensin II pressor response in normotensive rats at 0.1 mg/kg; reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, at 10 mg/kg per day, as well as in chow-fed control animals at 11.4 mg/kg per day; inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats
Cayman Chemical N3oxotetradec7 ZenoylL 10mg
A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity
Cayman Chemical 2TrIfluoromethyl2methoxyc 10mg
A potent activator of Nrf2; increases the expression of GCLM and NQO1 in human bronchial epithelial cells at 10 μM; increases GCLM and NQO1 expression by 4.5- and 4.6-fold, respectively, in the small intestine in mice at 50 mg/kg
Cayman Chemical BIsIndolylmaleImID IXmSyl 10mg
A potent, cell-permeable inhibitor of PKC isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively)
Cayman Chemical BIsIndolylmaleImID VIIIAC 10mg
A selective PKC inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC; exhibits PKC isozyme specificity with preference for PKCα over PKCβI, PKCβII, PKCγ, or PKCε (IC50s = 53, 195, 163, 213, and 175 nM, respectively)
Cayman Chemical DemethoxycurcumIn 10mg
A natural demethoxy derivative of curcumin; suppresses proliferation in cancer cells at 50-100 μM; down-regulates p300 and inhibits LPS-induced iNOS expression
Cayman Chemical DelphInIdInchlorIde 10mg
A natural plant pigment which induces the release of nitric oxide by vascular endothelium, causing vasorelaxation; inhibits signaling through EGFRs, suppressing the expression of ERα and inducing both apoptosis and autophagy at a dose of 1-40 μM; inhibits the HAT activities of p300/CBP (IC50 = ~30 μM)
Cayman Chemical DaHydroxyglutarIc AcIdod 10mg
An α-hydroxy acid; decreases the OCR and ratio of ATP to ADP in U87 cells at 800 µM; increases the levels of TBARS in isolated rat cerebral cortex homogenates at 100 µM; urinary levels are increased in D-2-hydroxyglutaric aciduria, a neurometabolic disease characterized by epilepsy, muscle hypotonia, and delays in psychomotor development; structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases
Cayman Chemical 4-hydroxy Nonal 10mg
A lipid peroxidation product derived from oxidized ω-6 PUFAs such as linoleic acid and arachidonic acid which is widely used as a marker of lipid peroxidation
Cayman Chemical ncrostatIn-2 10mg
A potent inhibitor of necroptosis (EC50 = 50 nM); 4-fold more active than the (S)-enantiomer (EC50 = 230 nM)
Cayman Chemical N3oxobutyrylLHomoserIn 10mg
A bacterial quorum-sensing signaling molecule; induces expression of rhiI in R. leguminosarum
Cayman Chemical JWH 200 nalog 1 10mg
Differs from JWH 200 by having 2,3,3-trimethyl-1-butene in place of the naphthyl group