Custom Peptides
Cayman Chemical RaloxIfenhydrochlorIde 10mg
An analytical reference standard categorized as an SERM; has been detected as an AAF during anti-doping testing; intended for use in analytical forensic applications
Cayman Chemical EndosIdIn 2 10mg
A cell-permeable inhibitor of exocytosis and endosomal recycling in plant and mammalian cells; binds the EXO70 subunit of the exocyst complex (Kd = 253 μM, EXO70A1); disrupts protein trafficking between the endosome and plasma membrane; enhances trafficking to the vacuole for degradation; inhibits recycling of endocytosed transferrin in HeLa cells
Cayman Chemical LY294002hydrochlorIde 10mg
A multi-kinase inhibitor; inhibits CK2 (IC50 = 0.098 µM), the PI3K subunits p110α, p110β, p110δ, and p110γ (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA-PK (IC50 = 6 µM), among other kinases, as well as CK1, GSK3α, and GSK3β by greater than 40% at 10 µM; inhibits LPS-induced activation of NF-κB in a reporter assay using RAW 264.7 macrophages at 20 µM; induces apoptosis and autophagy in SGC-7901 cells at 50 µM; reduces tumor volume in DLD-1 and LoVo mouse xenograft models at 2 ng/ml/kg; reduces aging-induced increases in the number of aging SA-β-gal-positive human VSMCs at 20 µM in the 5th to 15th generations
Cayman Chemical WaTx36-68scorpIontrIf 10mg
A cell-penetrating peptide and TRPA1 activator; selectively induces currents in HEK293T cells expressing human TRPA1 (EC50 = 15 nM) over cells expressing human TRPM8 or TRPV1 at 100 nM or rat Kv1.2, Kv2.1, Kv3.1, or Kv4.3 at 1,000 nM; induces nocifensive behavior in wild-type but not Trpa1-/- mice
Cayman Chemical Losartn CarboxylIc AcId 10mg
An AT1b receptor antagonist and active metabolite of losartan; an antagonist of AT1b (Kis = 0.67 nM in COS-7 cells expressing the human receptor); selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor); reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma at 50 µM; reduces MAP in water-deprived rats at 1 mg/kg
Cayman Chemical MalathIon-d6 10mg
An internal standard for the quantification of malathion by GC- or LC-MS
Cayman Chemical ML-252hydrochlorIde 10mg
A potent and selective inhibitor of Kv7.2 channels (IC50 = 69 nM); more potent than the (R)-enantiomer and racemic mixture (IC50s = 944 and 160 nM, respectively); selective for Kv7.2 over other Kv channel subtypes, G protein-coupled receptors, transporters, calcium channels, and KATP and hERG potassium channels; inhibits the MT1 receptor 61% when used at a concentration of 10 µM
Cayman Chemical zngbr offIcnle 10Shogaol 10mg
A phenol with diverse biological activities; selectively inhibits COX-2 over COX-1 (IC50s = 7.5 and >50 µM, respectively); induces mortality in A. cantonensis larvae at 100 and 200 µM; scavenges DPPH radicals in a cell-free assay at 100 µM; increases proliferation of isolated human keratinocytes and fibroblasts and migration of isolated human keratinocytes in a wound healing assay at 2 µM
Cayman Chemical 14-DeoxyndrographolIde 10mg
A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 UG/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model
Cayman Chemical ARUK3001185 10mg
An inhibitor of NOTUM (IC50 = 6.7 nM); selective for NOTUM over a panel of 39 serine hydrolases and 485 kinases, including CK1 and GSK3, at 10 µM and a panel of 47 receptors, ion channels, transporters, and enzymes at 30 µM, but does inhibit 5-HT3A, α4β2 subunit-containing nAChRs, and MAO-A (IC50s = 4.5, 10, and 28 µM, respectively); prevents NOTUM-induced decreases in Wnt3a signaling in a cell-based reporter assay (EC50 = 110 nM)
Cayman Chemical ZK 756326hydrochlorIde 10mg
A non-peptide agonist of CCR8; inhibits binding of CCL1 to human CCR8 (IC50 = 1.8 µM); stimulates extracellular acidification in cells expressing human and mouse CCR8 (EC50s = 254 nM and 2.6 µM, respectively); exhibits >28-fold selectivity for CCR8 over 26 other GPCRs; binds to the serotonergic receptors 5-HT1A, 5-HT2B, 5-HT2C, and 5-HT5A (IC50s = 5.4, 4.4, 34.8, and 16 µM, respectively); induces Gαi-mediated calcium mobilization, ERK phosphorylation, exhibits leukocyte chemotactic activity, and inhibits HIV fusion of cells expressing CD4 and CCR8
Cayman Chemical 28-AcetylbetulIn 10mg
A lupane triterpenoid with anti-inflammatory and anticancer activities; inhibits LPS-induced NO and PGE2 production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 µM, respectively); induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.38 µM, respectively)
Cayman Chemical GluR2831-842humnmouse 10mg
A peptide containing amino acids from the GluR2 C-terminal tail