Custom Peptides
Cayman Chemical Pixantrone (maleate), Purity: ≥95%, CAS: 144675-97-8, 10 mg
A DNA topoisomerase II inhibitor; induces SV40 DNA cleavage in the presence of mouse topoisomerase II; induces DNA single-strand breaks in NCI H187 cells; is cytotoxic to L1210 cells as well as doxorubicin-sensitive and -resistant LoVo cells (IC50 = 0.01, 0.24, and 7.2 µg/ml, respectively); decreases disease severity in a rat model of T. californica AChR immunization-induced myasthenia gravis at 8.12 mg/kg once per week for six weeks
Cayman Chemical Aliskiren (hemifumarate), Purity: ≥95%, CAS: 173334-58-2, 10 mg
A nonpeptide renin inhibitor (IC50 = 0.6 nM); reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes at 10 and 30 mg/kg
Cayman Chemical L-(+)-Erythrose, Purity: ≥95%, CAS: 533-49-3, 10 mg
An aldotetrose carbohydrate that has been used in glycation studies and to characterize erythrose reductase activity
Cayman Chemical Lamotrigine, Purity: ≥98%, CAS: 84057-84-1, 10 mg
An anticonvulsant; inhibits Nav1.2, Nav1.5, and Nav1.8 in HEK293 cells expressing the recombinant human channels (IC50s = 10, 62, and 96 μM, respectively); inhibits high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by ω-conotoxin GVIA and ω-agatoxin IVA; protects against MES-induced seizures in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively); decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg)
Cayman Chemical Clorgyline (hydrochloride), Purity: ≥98%, CAS: 17780-75-5, 10 mg
A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively); also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM)
Cayman Chemical Cilostamide, Purity: ≥98%, CAS: 68550-75-4, 10 mg
A selective inhibitor of PDE3A and PDE3B (IC50s = 27 and 50 nM, respectively); inhibits thrombin-induced platelet aggregation (IC50 = 1.1 μM)
Cayman Chemical Meclizine (hydrochloride), Purity: ≥98%, CAS: 36236-67-6, 10 mg
A histamine H1 receptor antagonist (Ki = 250 nM); reduces ovalbumin-induced mast cell degranulation, edema and leukocyte influx in rat lung from 2.5-30 mg/kg
Cayman Chemical Mitoxantrone (hydrochloride), Purity: ≥95%, CAS: 70476-82-3, 10 mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM
Cayman Chemical 6β-Prostaglandin I1, Purity: ≥99%, CAS: 62770-50-7, 10 mg
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.{509,1926}
Cayman Chemical Unoprostone, Purity: ≥98%, CAS: 120373-36-6, 10 mg
An agonist of FP receptors (EC50 = 4.12 µM), an active metabolite of unoprostone isopropyl ester. and a derivative of PGF2α; increases inositol phosphate production in HEK293 cells expressing the human receptor; prevents constant light-induced degradation of photoreceptors in rats at 1.2, 3.6, or 6 µg/µl
Cayman Chemical Dehydroergosterol, Purity: ≥95%, CAS: 516-85-8, 10 mg
A fluorescent cholesterol analog (ex/em = 324/375 nm) useful as a probe in membrane research
Cayman Chemical 4-bromo A23187, Purity: ≥95%, CAS: 76455-48-6, 10 mg
A non-fluorescent analog of the highly selective calcium ionophore A23187; used in experiments where fluorescent probes are employed
Cayman Chemical 16α-hydroxy Estrone, Purity: ≥98%, CAS: 566-76-7, 10 mg
A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7; binds covalently and persistently activates estrogen receptors; increases cell proliferation and does not suppress TNF-α secretion
Cayman Chemical Atglistatin, Purity: ≥95%, CAS: 1469924-27-3, 10 mg
A potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM); does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases; blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo
Cayman Chemical AT7519 (hydrochloride), Purity: ≥98%, CAS: 902135-91-5, 10 mg
An ATP-competitive inhibitor of Cdk1, 2, 4, 5, 6, and 9 with IC50 values of 210, 47, 100, 13, 170, and 50s = 40-940 nM in vitro) and human tumor xenograft models, inhibiting cell cycle progression and inducing apoptosis