Custom Peptides
Cayman Chemical C17 SphngomyelInd18 117 0 10mg
A synthetic derivative of sphingomyelin; has been used as an internal standard for the quantification of sphingomyelin
Cayman Chemical Butenoyl PAF 10mg
A product of the oxidative decomposition of 2-arachidonoyl phospholipids; 10-fold less potent than PAF as a PAF receptor agonist, but present in amounts 100-fold greater
Cayman Chemical 2Omethyl PAF C18hydrAT 10mg
A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position; decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS
Cayman Chemical VarenIclIntartrate 10mg
An agonist of α7 and α4β2 nAChRs (EC50s = 18 and 2.3 µM, respectively)
Cayman Chemical MurIdeoxycholIc AcId 10mg
A secondary bile acid produced from α-muricholic acid and β-muricholic acid; metabolite of lithocholic acid; prevents gallstones in hamsters; does not resolve gallstones in prairie dogs and induces formation of insoluble bile acid salt gallstones; rapidly absorbed in humans
Cayman Chemical TIP39humnbovIntrIflu 10mg
A neuropeptide and PTH2R agonist; induces cAMP accumulation in COS-7 cells expressing recombinant human or rat PTH2R (EC50s = 0.5 and 0.8 nM, respectively) and F-11 cells that endogenously express PTH2R (EC50 = 1.15 nM); induces cell cycle arrest at the G0/G1 phase and decreases expression of Sox9 in CFK2 rat chondrocytes at 1 nM; decreases immobility time in the forced swim test in mice
Cayman Chemical DIflucortolon 21-valerate 10mg
A glucocorticoid; has anti-inflammatory effects in a rat model of croton oil-induced EAr edema when applied topically (ED50 = 9.7 UG/ml); induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration at 0.1%; increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization
Cayman Chemical SynthetIc DIeugenol 10mg
A neolignan with antioxidative and antiprotozoal activities; inhibits TBARS formation and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays; has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s = 15.1 and 11.5 µM, respectively) but is cytotoxic to NCTC L-929 fibroblasts (CC50 = 58.2 µM); disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce ROS production in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages
Cayman Chemical 5fluoro PB22 7hdroxIsoqu 10mg
Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its seven position; intended for forensic and research purposes
Cayman Chemical zngbr offIcnle 8Gngerol 10mg
A natural chemical that activates TRPV1 (EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pylori in vitro; also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle
Cayman Chemical PhenformInd5hydrochLRIde 10mg
An internal standard for the quantification of phenformin by GC- or LC-MS
Cayman Chemical PLX5622hemIfumarate 10mg
A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm in the chow