Custom Peptides
Cayman Chemical 5fluoro PB22 6hdroxIsoqu 10mg
Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its six position; intended for forensic and research purposes
Cayman Chemical RaltegravIrpotasIum salt 10mg
An orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay); inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s = 19 and 31 nM in medium containing 10% heat-inactivated FBS or 50% normal human serum, respectively); is metabolized in the liver primarily by UGT1A1
Cayman Chemical 1Stearoyl2Oleoylsnglycer 10mg
A phospholipid; has been used in the generation of LNPs for in vitro delivery of mRNA or nuclear-targeted plasmid DNA
Cayman Chemical 1 2DInonadecnoylsnglycero 10mg
A saturated phospholipid; has been used as a standard for the quantification of phosphatidylcholines in human synovial fluid; has been used to study dynamics of lipid bilayer phase transition
Cayman Chemical GGACKhydrochlorIde 10mg
A uPA and factor Xa inhibitor (Kis = 1.8 and 8.7 µM, respectively)
Cayman Chemical 8-AzaadenosIn 10mg
A nucleoside analog and an ADAR1 inhibitor; inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and Cal-62 thyroid cancer cells at 1 and 2 µM; increases the ex vivo secretion of IFN-γ and TNF-α from CD8+ T cells isolated from mouse spleen in a model of HBV infection at 2 mg/kg; decreases serum HBsAg levels in the same model
Cayman Chemical Lnraplenb 10mg
A Syk inhibitor (IC50 = 6.2 nM); selective for Syk over a panel of 395 kinases but does inhibit JAK2 (IC50 = 120 nM); reduces anti-IgM- and anti-CD40-induced proliferation of isolated human B cells (EC50 = 108 nM); inhibits immune complex-induced production of TNF-α, IL-1β, and IL-6 in human macrophages (EC50s = 180, 90, and 700 nM, respectively); reduces proteinuria and increases survival in the NZBWF1 mouse model of SLE
Cayman Chemical BzNleKRRAMChydrochlorIde 10mg
A fluorogenic substrate for YFV NS3 or DV NS2B/3 serine proteases; AMC is released upon enzymatic cleavage by YFV NS3 or DV NS2B/3 serine proteases and its fluorescence can be used to quantify YFV NS3 or DV NS2B/3 serine protease activity; ex/em = 340-360/440-460 nm, respectively
Cayman Chemical EfaroxnhydrochlorIde 10mg
An α2-AR (EC50s = 1 receptor antagonist; binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively); binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion at 100 μM; binds to rat RIN-5AH insulinoma cell membranes (IC50g = 32 nM) and stimulates insulin secretion at 100 μM; lowers basal blood glucose levels in mice at 5 mg/kg; increases L-DOPA synthesis in rat cortex and hippocampus by 77 and 57%, respectively at 10 mg/kg
Cayman Chemical MeOSucRPYpNAtrIfluoroace 10mg
A colorimetric serine protease substrate; cleavage of the RPY peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity
Cayman Chemical ngenol-3-ngelate 10mg
A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity
Cayman Chemical SertralInhydrochlorIde 10mg
A selective serotonin reuptake inhibitor; inhibits monoamine uptake by SERT (IC50 = 70 nM); selective for SERT over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively); reduces immobility in the forced swim test in mice at 3.2-56 mg/kg, s.c.; prevents acid sphingomyelinase activation and subsequent ceramide release induced by pp-VSV-SARS-CoV-2 infection in Vero cells at 5 µM
Cayman Chemical PItavastatIncalcIum salt 10mg
An HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme); inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively); reduces plasma levels of triglycerides and total cholesterol in dogs; increases survival in Dahl salt-sensitive rats fed a high-salt diet at 0.3 mg/kg
Cayman Chemical ATM4 4-acetoxy nalog 10mg
An analytical reference standard categorized as a potential impurity in the synthesis of heroin; has been found in seized heroin samples; intended for research and forensic applications