Custom Peptides
Cayman Chemical 16a-hydroxy Estron 10mg
A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7; binds covalently and persistently activates estrogen receptors; increases cell proliferation and does not suppress TNF-α secretion
Cayman Chemical TamsulosInhydrochlorIde 10mg
A potent α1-AR antagonist (Ki = 0.229 nM in a radioligand binding assay); 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM); antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin, angiotensin II, or prostaglandin F2α; reverses the phenylephrine-induced pressor effect in pithed rats; reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg; reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs
Cayman Chemical RaltegravIrpotasIum salt 10mg
An orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay); inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s = 19 and 31 nM in medium containing 10% heat-inactivated FBS or 50% normal human serum, respectively); is metabolized in the liver primarily by UGT1A1
Cayman Chemical RostafuroxIn 10mg
Prevents binding of endogenous ouabain to the Na+/K+ ATPase (IC50 = 1.7 µM)
Cayman Chemical L-Erythrose 10mg
An aldotetrose carbohydrate that has been used in glycation studies and to characterize erythrose reductase activity
Cayman Chemical P276-00hydrochlorIde 10mg
A Cdk9, Cdk4, and Cdk1 inhibitor (IC50s = 0.020, 0.063, and 0.079 µM, respectively); selective for these CDKs over Cdk2/cyclin E, Cdk2/cyclin A, Cdk6, and Cdk7 (IC50s = 2.54, 0.224, 0.396, and 2.87 µM, respectively), as well as a panel of eight other kinases; induces apoptosis in HL-60 cells at 1 µM; induces cell cycle arrest at the G1 phase in synchronized H460 cells at 1.5 and 5 µM; reduces tumor volume in a H460 mouse xenograft model at 50 mg/kg once per day; inhibits reactivation of latent HIV-1 induced by prostratin, panobinostat, or JQ-1 in 24ST1NLESG cells (IC50s = 0.1, 0.07, and 0.075 µM, respectively)
Cayman Chemical MalntIdetrIfluoroacetAT s 10mg
A fluorescent substrate for PKA and PKC; upon phosphorylation by PKA or PKC, the intrinsic tyrosine fluorescence decreases and can be used to quantify PKA and PKC activity; ex/em = 285/302 nm
Cayman Chemical Cholesterol-3 4-13C2 10mg
An internal standard for the quantification of cholesterol by GC- or LC-MS
Cayman Chemical Desacetylcinobufagin 10MG
An active metabolite of cinobufagin; cytotoxic to HepG2, K562, and HL-60 cells (IC50s = 51.2, 50.1, and 7.5 µM, respectively)
Cayman Chemical NpTosylGlyProLyspNAac 10mg
A colorimetric plasmin substrate; hydrolysis releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of plasmin activity
Cayman Chemical SynthetIc ScoulerIn 10mg
A benzylisoquinoline alkaloid with diverse biological activities; selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over 5-HT1A and 5-HT2A receptor subtypes in HEK293 cells at 10 µM; inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 µM); inhibits methamphetamine-induced conditioned place preference in mice at 5 mg/kg
Cayman Chemical PItavastatIncalcIum salt 10mg
An HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme); inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively); reduces plasma levels of triglycerides and total cholesterol in dogs; increases survival in Dahl salt-sensitive rats fed a high-salt diet at 0.3 mg/kg
Cayman Chemical RIzatrIptnbenzoate salt 10mg
A 5-HT1B and 5-HT1D receptor agonist (Kis = 4.3 and 10.1 nM, respectively); selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors (Ki = 140 nM); induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 90 nM); reduces pain behaviors and photophobia in a Cacna1a mutant transgenic mouse model of migraine at 50 and 75 mg/kg
Cayman Chemical Gnkgo bloba L Blobalde 10mg
A sesquiterpene lactone which protects against cerebral edema, decreases cortical infarct volume, and reduces cerebral ischemic damage; at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions; increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes
Cayman Chemical 2 NEthylperfluoroctnsulf 10mg
A perfluoroalkyl substance; has been found in wastewater samples; associated with decreased plasma levels of maternal and fetal free T4