Custom Peptides
Cayman Chemical BupIvacaIn-d9 10mg
A multi-kinase inhibitor that inhibits VEGFR2 VEGFR3 VEGFR1 EGFR PDGFRB Tie-2 and FGFR1 (IC50s 40 110 1600 500 1100 2500 and 3600 nM respectively in cell-free assays) also binds to 142 additional kinases in a panel of 442 kinases (Kds 4.6-7900 nM) induces apoptosis and cell cycle arrest at the G0/G1 phase in GEO colon and OVCAR-3 ovarian cancer cells at 1 and 2.5 UM inhibits proliferation of HAK1-B KYN-2 and Huh7 hepatocarcinoma cells and HUVECs (IC50s 10 8.1 9.4 and 7.1 UM respectively) increases survival and decreases tumor angiogenesis and VEGFR2 levels in a D54MG glioblastoma mouse xenograft model at 200 mg/kg reduces tumor growth in a variety of mouse xenograft models at 25-100 mg/kg per day
Cayman Chemical Cytosporon B 10mg
A potent competitive inhibitor of both Src and Lck (IC50 44 and 88 nM respectively) as well as Csk and Yes also inhibits RIP-2
Cayman Chemical nacardIc AcId monen 10mg
A skeletal muscle relaxant inhibits the proliferation of and induces apoptosis in RAW 264.7 cells from 1-100 UM reduces LPS-induced increases in COX-1 COX-2 and NF-kB levels and inhibits LPS-induced production of TNF-a IL-6 and PGE2 in RAW 264.7 cells
Cayman Chemical UmIfenovIrhydrochlorIde 10mg
A precursor of cysteine formed in the methionine transsulfuration pathway deficiency can indicate the presence of metabolic disorders such as cystathioninuria
Cayman Chemical LasofoxIfentartrate 10mg
A thio analog of the purine base guanine that incorporates into DNA during replication inducing double-strand breaks that destabilize its structure and result in cytotoxicity used as a chemotherapeutic for acute leukemia and other types of cancer including BRCA2-mutated tumors
Cayman Chemical 11-keto Fluprostenol 10mg
An HIV-1 protease inhibitor active against HIV-1LAI in MT-2 cells (IC50 3 nM) (CC50 74.4 M) active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s 3 and 3-29 nM respectively) inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s 2.5 and 2.8 nM respectively)
Cayman Chemical ProstaglndIn I2sodIM salt 10mg
A bioactive oxysterol a major oxysterol component of oxidized LDL produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by CYP7A1 inhibits CYP7A1 (IC50 ~1 M) induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state increases ocular levels of VEGF IL-1B and GRO/KC macrophage infiltration and neovascularization in rat eye levels are increased in lipid deposits in a variety of chronic diseases
Cayman Chemical LCysteInglutathIon dIsulf 10mg
8-iso PGF2B is an isomer of PGF2a with a non-enzymatic non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2a which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2B exhibits very weak contraction of human umbilical vein artery{11143} and does not promote aggregation of human whole blood.{1114311145} However 8-iso PGF2B moderately contracts both the canine and porcine pulmonary vein although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1 8-iso PGE2 or 8-iso PGF2a{1114411146}
Cayman Chemical RPramIpexolehydrochLRId 10mg
An EZH2 inhibitor (IC50 11 nM) inhibits mutant EZH2 including EZH2A677G EZH2A687V and EZH2Y641F and EZH2Y641S (IC50s 2 2 14 and 4 nM respectively) selective for wild-type and mutant EZH2 over EZH1 (IC50 392 nM) and a variety of other histone methyltransferases (IC50s 50 or 100 UM for all) reduces H3K27me3 levels in various lymphoma cell lines expressing wild-type or mutant EZH2 (IC50s 2-8 and 2-22 nM respectively) inhibits proliferation of various lymphoma cell lines expressing wild-type or mutant EZH2 (IC50s 0.099-6.2 and 0.00049-5.8 UM respectively) induces insulin production and glucose-stimulated insulin secretion in human pancreatic exocrine cells isolated from juvenile patients with type 1 diabetes or adults without diabetes at 1 UM reduces H3K27me3 levels and induces insulin secretion and glucose-stimulated insulin secretion in human pancreatic ductal epithelial cells in vitro
Cayman Chemical BetaIn AldehydechlorIde 10mg
A monotetrazolium salt used as an indicator dye reduced to an insoluble formazan that is used as a vital dye or indicator of cellular redox activity commonly used to measure the respiratory activity of microorganisms in a variety of contexts
Cayman Chemical XL147 nalog 2 10mg
An inhibitor of both a- andBglucosidases inhibiting lysosomal and neutral a-glucosidases with Ki values of 0.1 and 10 M respectively and lysosomal and cytosolicBglucosidases with Ki values of 7 and 40 M respectively blocks N-linked glycosylation affecting protein trafficking
Cayman Chemical DelafloxacIn 10mg
A quinolone antibiotic that inhibits bacterial DNA gyrase but not eukaryotic topoisomerases reversibly binding gyrase subunit A in gyrase-DNA complexes blocking supercoiling activity and inhibiting DNA synthesis at 0 5-5 Ug/ml also blocks neuronal uptake of dopamine in mammals (IC50 4 3 UM)
Cayman Chemical 6FormylIndolo3 2bcarbazol 10mg
A flavonoid with diverse biological activities inhibits CYP1A1 and CYP1B1 (Kis 89 and 16 nM respectively) prevents AAPH-induced increases in erythrocyte ROS and MDA levels in a concentration-dependent manner reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model at 1 mg/kg twice per day inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in BALF in a mouse model of ovalbumin-induced chronic asthma at 0 5 mg/kg
Cayman Chemical 4AMNoPHNylphsphorylcholn 10mg
A cell permeable competitive and reversible inhibitor of cGKs that blocks activation of cGKI and cGKII by cGMP (Kis 35 and 30 nM) less potently inhibits PKA (Ki 11 UM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 25 UM) resistant to hydrolysis by PDE11
