Custom Peptides
Cayman Chemical 7-ChlorokynurenIc AcId 10mg
A glycine-site selective NMDA receptor antagonist; selectively binds to the NMDA receptor glycine-binding site (IC50 = 0.56 µM) over the NMDA-, quisqualate-, and kainate-binding sites (IC50s = 169, 153, and >1,000 µM, respectively); induces antidepressant-like activity in a variety of behavioral tests in mice at 0.1 and 1 mg/kg
Cayman Chemical 2 5-nhydro-D-mnItol 10mg
An antimetabolic fructose analogue that increases food intake in rats
Cayman Chemical SID 3712249 10mg
An inhibitor of miR-544 biogenesis; increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, HIF-1α, and ATM in MDA-MB-231, MCF-7, and MCF-10A cells under hypoxic conditions at 20 nM; induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner at 20 nM; enhances the senstivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to 5-FU-induced decreases in cell viability at 20 nM; reduces tumor growth in an MDA-MB-231 mouse xenograft model
Cayman Chemical TopIroxostat 10mg
An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); inhibits ABCG2 in isolated human plasma (IC50 = 0.18 µM); increases LPS-induced decreases in Bcl-2 levels and decreases LPS-induced increases of Bax and cleaved caspase-3 levels in H9c2 rat cardiomyocytes at 5 µM; chronic administration results in the presence of urinary xanthine crystals and induces nephropathy in rats at 0.2 and 1 mg/kg, respectively
Cayman Chemical TrovafloxacInmesylate 10mg
A broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 UG/ml) and DNA gyrase (IC50 = 7.13 UG/ml)
Cayman Chemical MCOPPBhydroCLOrID hydrate 10mg
A potent, selective agonist for the nociceptin receptor (pKi = 10.1, EC50 = 0.39 nM); produces potent anxiolytic effects in rodents at 10 mg/kg, p.o. without inhibiting memory or motor function or inducing sedative side effects
Cayman Chemical 1-O-CaffeoylquInIc AcId 10mg
A phenolic acid; binds the NF-κB precursor protein p105 (Ki = 0.007 µM); binds PD-1 (KD = 12.4 µM) and inhibits the protein-protein interaction between PD-1 and PD-L1 (IC50 = 87.28 µM)
Cayman Chemical 3mthylaPyrroldInopropIop 10mg
A structural isomer of methyl-α-PPP, having the methyl group at the 3 position, rather than the 4 position, of the phenyl group; intended for forensic and research applications
Cayman Chemical 2 1 8NaphthyrIdIn2ylphen 10mg
A STAT1 activity enhancer; enhances IFN-γ-induced STAT1-dependent signaling at 45 µM; increases IFN-γ-induced IRF3 expression and STAT1 phosphorylation in NIH3T3 cells at 45 µM; increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at 45 µM
Cayman Chemical AM92016hydrochlorIde 10mg
An IKr inhibitor (IC50 = 40 nM in isolated rabbit sinoatrial node cells); selective for IKr over L-type Cav current and If at 1 µM; decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells at 50 nM; decreases the QT interval and increases heart rate in anesthetized guinea pigs at 1 mg/kg; decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs at 1 mg/kg
Cayman Chemical PImavnserIn 10mg
A 5-HT2A inverse agonist (IC50 = 1.86 nM; Ki = 0.5 nM); selective for 5-HT2A over a panel of 65 ion channels, enzymes, and receptors (Kis = >100 nM); reduces DOI-induced head-twitch behavior and prepulse inhibition deficits in rats at doses of 3 mg/kg, p.o. and 1-10 mg/kg, s.c., respectively; exhibits antipsychotic-like activity, reducing (+)-MK-801-induced hyperactivity in mice; acts synergistically with haloperidol or risperidone to suppress (+)-MK-801-induced hyperactivity and attenuates haloperidol- and risperidone-induced catalepsy in rats
Cayman Chemical ProcynIdIn A1 10mg
A polyphenol flavonoid dimer with diverse biological activities; binds to PlGF and VEGF (Kds = 394 and 476 nM, respectively); increases the activity of JAK2 (EC50 = 660 nM); scavenges superoxide radicals (IC50 = 14.7 µM); inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 14 UG/ml); increases the proliferation of isolated mouse splenocytes and peritoneal macrophages from 25-100 µM and DAMI megakaryoblasts (EC50 = 8.58 µM); prevents decreases in the number of platelets in peripheral blood and megakaryocytes in the bone marrow in a mouse model of carboplatin-induced thrombocytopenia at 50 mg/kg
Cayman Chemical Guafensn 10mg
An analytical reference standard categorized as an expectorant; intended for use in analytical forensic applications
Cayman Chemical GabaculInhydrochlorIde 10mg
An irreversible inhibitor of GABA-T (Ki = 2.9 μM); irreversibly inhibits D-amino acid transaminase, L-alanine transaminase, and L-aspartate transaminase (Kis = 0.1, 1, and 55 mM, respectively); irreversibly inhibits ornithine aminotransferase in vitro and in mouse brain and liver homogenates; increases latency to convulsion in the 3-mercaptopropionic acid-induced and minimal electroshock-induced seizure models (ED50s = 135 and 200 mg/kg, respectively); inhibits 3-mercaptopropionic acid-induced increases in GAD and GABA-T activity in mice (ED50s = 135 mg/kg); LD50 = 62 mg/kg; elevates concentrations of GABA in mouse brain by over 500% and reduces GABA-T activity to below detection limits (135 mg/kg, i.p.)