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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures allowing the transcriptional machinery to access its targets more effectively The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase This gene has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors Alternatively spliced transcript variants have been found for this gene
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Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit The protein encoded by this gene represents the catalytic subunit which uses ATP to phosphorylate PtdIns PtdIns4P and PtdIns(4 5)P2 This gene has been found to be oncogenic and has been implicated in cervical cancers A pseudogene of this gene has been defined on chromosome 22
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Concentrated buffer solution recommended for resuspension and long-term storage of any short, double-strand, or single-strand synthetic RNA molecule. Dilute with RNase-free water prior to use.
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