Bioactive Small Molecules
Medchemexpress LLC BRD0539 | 1403838-79-8 | 98.33% | 452.54 | 100 MG
BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC50 of 22 μM in an in vitro DNA cleavage assay.
- Dose-dependently blocks the formation of the DNA-bound state.
- Impairs the perturbation induced by 4PAM DNA.
- Does not interfere with the SpCas9:gRNA interaction.
- Inhibits SpCas9 in the eGFP-disruption assay.
- Unable to inhibit FnCpf1.
Medchemexpress LLC Diclofenac epolamine | 119623-66-4 | 99.9% | 411.32 | 1 ML
Diclofenac epolamine is a non-steroidal anti-inflammatory drug (NSAID). It is used for relieving arthritis pain, acute pain, osteoarthritis, and actinic keratosis. It has good skin absorption characteristics without local adverse reactions and allergies.
- Acts as a non-steroidal anti-inflammatory drug (NSAID)
- Used for relieving arthritis pain, acute pain, osteoarthritis, and actinic keratosis
- Provides good skin absorption characteristics without local adverse reactions and allergies
- Increases diclofenac partitioning into the skin
- Enhances the transport of drug through skin and sustains for 12 hours after removal of microemulsion (ME)
- Effective in treating inflammatory conditions
Cayman Chemical GnRH IItrIfluoroacetAT sal 5mg
A GnRHR agonist; binds to recombinant human type I and marmoset type II GnRHRs expressed in COS-7 cells (IC50s = 26.1 and 1.07 nM, respectively) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively); stimulates LH and FSH release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively); increases plasma LH levels in White Leghorn pullets (1 μg/kg, i.v.); decreases food intake in zebrafish (1 pmol/g, i.c.v.); increases courtship behavior in female white-crowned sparrows (100 ng, i.c.v.)
Cayman Chemical ANTIBODY LDAO 1g
A zwitterionic detergent; can be used to solubilize membrane proteins; has been used to solubilize and extract colicin A from the plasma membrane, to inactivate enveloped viruses, and, in combination with 10MAG, to encapsulate proteins and nucleic acids dissolved in low viscosity fluids
Medchemexpress LLC Epidermal growth factor, human recombinant (C-terminal 6xHis tag) | >95.0% | 2UG
Recombinant human epidermal growth factor (EGF) produced without animal-derived materials. The protein is expressed in Escherichia coli and supplied as a lyophilized powder with a C-terminal 6xHis tag. It is characterized by high purity and potent biological activity suitable for cell-based assays and research applications, with recommended reconstitution and storage conditions provided by the manufacturer.
- Produced without animal-derived materials.
- Expressed in Escherichia coli with a C-terminal 6xHis tag.
- Supplied as lyophilized powder for long-term stability.
- Purity greater than 95% by reducing SDS-PAGE.
- Approximate molecular weight 9-11 kDa.
- High biological activity; ED50 ~0.736 ng/mL in cell proliferation assays.
- Recommended reconstitution 100-200 μg/mL; store at -20°C or colder.
Medchemexpress LLC Sulopenem etzadroxil | 1000296-70-7 | 99.8% | 477.62 | 10 MG
Sulopenem etzadroxil is an orally active prodrug of the antibiotic Sulopenem. It demonstrates in vivo activity against *Bacillus anthracis* in a murine model, with survival rates comparable to those of the Ciprofloxacin-positive control. This makes it suitable for research in infection and antibacterial studies.
- Orally active prodrug of Sulopenem
- Active against *Bacillus anthracis*
- Comparable survival rates to Ciprofloxacin in murine models
- White to light yellow solid appearance
Cayman Chemical PhosphatIdylserInsoysod 5mg
A mixture of soy phosphatidylserines; comprises 2-10% of total phospholipids in mammals and is enriched in the brain; found mainly on the inner leaflet of the cell membrane; synthesized in the ER and mitochondria; is a precursor to phosphatidylcholine and phosphatidylethanolamine; cofactor for various signaling pathways; externalized during apoptosis as a signal for phagocytes to engulf the cell
Medchemexpress LLC Abarelix acetate | 547741-72-0 | 99.9% | C74H99ClN14O16 | 10MG
Abarelix acetate is a gonadotrophin-releasing hormone (GnRH) receptor antagonist used in prostate cancer research. Supplied as the acetate salt, the compound is documented with chemical identifiers, analytical data, and reported high purity for use in in vitro and preclinical studies.
- Potent GnRH receptor antagonist activity
- Documented molecular formula C74H99ClN14O16 and molecular weight 1476.12
- Reported purity 99.9% suitable for biochemical assays
- Available in multiple small-scale sizes for research use
- Suitable for in vitro and preclinical prostate cancer studies
- Supplied with accompanying datasheet containing analytical data
Medchemexpress LLC Hexanoylglycine-d2 | 1256842-52-0 | 98.0% | 175.22 | C8H13D2NO3 | 5 MG
Hexanoylglycine-d2 is the deuterium-labeled analogue of hexanoylglycine used as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS. Supplied as a white to off-white solid with high purity, it is intended for analytical and metabolomics workflows requiring isotopically labeled standards.
- High purity (98.0%).
- Molecular weight 175.22.
- Chemical formula C8H13D2NO3.
- Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
- Stable as powder at -20°C (3 years) or 4°C (2 years).
- Suitable as tracer and internal standard for NMR, GC-MS, and LC-MS.
TARGETMOL CHEMICALS INC ASTRAGALOSIDE II 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities differentiation proliferation and mineralization through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. purity: 99%
Medchemexpress LLC Vonafexor (EYP001) | 1192171-69-9 | 99.4% | 489.76 | 100 MG
Vonafexor (EYP001) is an orally active, non-steroidal, and selective FXR agonist. It significantly reduces HBsAg when combined with Peg-IFNα and can be used for anti-HBV research. In vitro, Vonafexor inhibits HBV replication in HepaRG cells, leading to significant reductions in HBV DNA, HBsAg, and HBeAg secretion. This effect is enhanced when combined with Entecavir or Tenofovir.
- Orally active, non-steroidal, and selective FXR agonist.
- Shows significant HBsAg reduction when combined with Peg-IFNα.
- Can be used for anti-HBV research.
- Inhibits HBV replication cycle in HepaRG cells.
- Additive effects when combined with Entecavir or Tenofovir in inhibiting HBV DNA, HBsAg, and HBeAg secretion.
Medchemexpress LLC Vonafexor | 1192171-69-9 | 99.38% | 489.76 | 50 MG
Vonafexor (EYP001) is an orally active, non-steroidal and selective FXR agonist. It demonstrates significant HBsAg reduction when combined with Peg-IFNα and can be utilized for anti-HBV research. In vitro, Vonafexor inhibits the HBV replication cycle in HepaRG cells, leading to substantial reductions in HBV DNA, HBsAg, and HBeAg secretion, with additive effects when combined with Entecavir or Tenofovir.
- Orally active, non-steroidal, and selective FXR agonist.
- Shows significant HBsAg reduction when combined with Peg-IFNα.
- Can be used for anti-HBV research.
- Inhibits HBV replication cycle in HepaRG cells.
- Additive anti-HBV effects when combined with Entecavir or Tenofovir.
Cayman Chemical ANTIBODY BMS 191011 5mg
A KCa1.1/BK channel activator; increases maximum potassium current to 126% of control X. laevis oocytes expressing human KCa1.1 channels at 1 μM; increases the diameter of retinal arterioles in rats from 10-100 μg/kg
Apexbio Technology LLC Tigecycline, 5mg. Cas: 220620-09-7 MFCD: MFCD00935753. Glycylcycline antibiotic
Tigecycline, the first commercially available member of the glycylcyclines, is a new class of antimicrobial agents. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Simethicone | 8050-81-5 | 96.0% | 1 ML
Simethicone is an orally active defoamer that reduces the surface tension of air bubbles in the gastrointestinal tract, leading to their expulsion by vomiting, exhalation, or absorption into the bloodstream. It has potential applications in flatulence and colic.
- Reduces surface tension of air bubbles in the gastrointestinal tract.
- Facilitates expulsion of air bubbles by vomiting, exhalation, or absorption.
- Potential applications in flatulence and colic.
- Demonstrated gastrointestinal regulation function in rats.
- Improved colon permeability and hypersensitivity in rats.
- Improved image quality scores for the jejunum in rabbits.