Bioactive Small Molecules
Cayman Chemical ToyocamycInhydrate 5mg
A natural adenosine analog that prevents IRE1α-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines; used to study IRE1α action in the endoplasmic reticulum stress response
Cayman Chemical ANTIBODY nratInIb 25mg
A dual inhibitor of EGFR and HER2 (IC50s = 92 and 59 nM, respectively); selective for EGFR and HER2 over a panel of 12 kinases (IC50s = >5,000 nM) but does inhibit VEGFR2 and Src (IC50s = 800 and 1,400 nM, respectively); inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s = 0.2-3 nM); reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
Cayman Chemical ANTIBODY ME0328 10mg
A selective inhibitor of PARP3 (IC50 = 0.89 µM); cell permeable and elicits PARP3-specific effects at submicromolar concentrations
Cayman Chemical ANTIBODY Gestoden 250mg
A progestin; selectively binds to the progesterone receptor over the estrogen receptor; induces transcriptional activity mediated by the progesterone receptor, and, weakly, the androgen receptor in reporter assays; increases the growth of MCF-7 cells at 0.1-1 µM; reduces tumor growth in an estrogen-dependent model of DMBA-induced rat mammary tumors at 0.1 mg/kg
Cayman Chemical ANTIBODY SR 1078 1mg
A selective RORα and RORγ agonist that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related LXR and FXR receptors; stabilizes p53 and induces apoptosis in HepG2 cancer cells
Cayman Chemical ANTIBODY UNC2025 25mg
A potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively); blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo
Cayman Chemical ANTIBODY Wnt-C59 5mg
A potent inhibitor of PORCN (IC50 = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target genes in mice
Cayman Chemical ANTIBODY EquIsetIn 1mg
An HIV-1 integrase inhibitor; inhibits Dnp-stimulated ATPase activity of rat liver mitochondria and mitoplasts (IC50 = ~8 nM per mg of protein for both); inhibits ADP-stimulated respiration and the mitochondrial transport of ATP, inorganic phosphate, and succinate; phytotoxic
Cayman Chemical OTsP167hydrochlorIde 5mg
A potent inhibitor of MELK (IC50 = 0.41 nM); blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel; suppresses the growth of xenograft tumors in mice
Cayman Chemical 15deoxy12 14ProstaglndIn 5mg
This formulation of 15-deoxy-.DELTA.12,14-PGJ2 contains 90-95% of the trans,trans-.DELTA.12,14 isomer, and 5-10% of other double bond isomers which have similar PPARγ ligand activity (see Catalog No. 18570).
Amsbio LLC Stemolecule LDN-193189 in Solution (2 mg (10 mM))
Stemolecule LDN-193189 in Solution (2 mg (10 mM))
Cayman Chemical OlendomycIn 5mg
A classic macrolide antibiotic produced by strains of Streptomyces that demonstrates antimicrobial activity similar to penicillin and erythromycin
Cayman Chemical ANTIBODY UNC2250 10mg
A selective inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM; inhibits Mer activity in cells and displays good pharmacokinetic properties in mice following intravenous or oral administration
Cayman Chemical ANTIBODY GDC-0152 1mg
A potent inhibitor of specific IAPs that binds baculovirus IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively); induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells