Bioactive Small Molecules
Cayman Chemical ANTIBODY CorIlagIn 10mg
A polyphenol and hydrolyzable tannin that inhibits squalene epoxidase (IC50 = 4.0 µM), a key enzyme in cholesterol synthesis; has various anti-inflammatory and anti-cancer effects
Cayman Chemical 7-AmInoactInomycIn D 5mg
A fluorescent DNA dye; commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis; ex/em = 488, 546, 578/650 nm, respectively; exhibits minimal spectral overlap with commonly used probes, therfore it can be used in conjunction with probes such as FITC; has been used to evaluate apoptosis and cell-mediated cytotoxicity and to stain DNA in cells that have been fixed and permeabilized by a variety of methods
Cayman Chemical 14deoxy11 12dIdehydro ndr 5mg
A noncytotoxic analog of the natural diterpenoid that possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities
Cayman Chemical Farnsyl ThIosalcylc ACD A 5mg
An inhibitor of Ras-mediated signaling that inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM, respectively
Cayman Chemical ANTIBODY LazabemIde 50mg
An inhibitor of MAO-B (Ki = 0.084 µM); selective for MAO-B over MAO-A (IC50s = 0.02 and 640 µM, respectively); inhibits rat liver MAO-B ex vivo (ED50 = 53 nmol/kg); inhibits ischemia-reperfusion injury-induced hydroxyl radical formation in mouse cerebral ventricles at 3 mg/kg
Cayman Chemical ANTIBODY ActInonIn 25mg
A peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases, including MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM); also targets peptide deformylase and meprin α (Ki = 20 nM)
Cayman Chemical ANTIBODY Butafosfn 5g
An organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies
Cayman Chemical ANTIBODY RAF265 1mg
A dual inhibitor of mutant B-RafV600E and VEGFR2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays) that also inhibits wild-type B-Raf, PDGFR, CSF1R, RET, c-KIT, SRC, and STE20 (IC50s = 20-100 nM)
Cayman Chemical ANTIBODY BIIB-057 10mg
A potent, selective, orally bioavailable inhibitor of Syk (IC50 = 1 nM); blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 µM, respectively); inhibits inflammation and tumor growth in animal models of rheumatoid arthritis and non-Hodgkin lymphoma, respectively
Cayman Chemical ANTIBODY Cu-ATSM 10mg
A copper-containing compound with diverse biological activities; inhibits ferroptotic cell death induced by RSL3, erastin, or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells at 1 µM; increases SOD1G37R protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of ALS at 30 mg/kg per day; increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model; versions containing positron-emitting copper isotopes have been used in PET imaging applications for selective labeling of hypoxic tissue
Cayman Chemical MIlbemycIn A4 5mg
The prominent member of a complex family of macrocyclic lactones produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus; nematocide and insecticide activity via the potentiation of glutamate and GABA-gated chloride-channel opening
Cayman Chemical ANTIBODY WWL123 1mg
A brain-penetrant, selective inhibitor of ABHD6 (IC50 = 0.43 µM) that has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models
Cayman Chemical ANTIBODY DIosmetIn 1g
A flavonoid with diverse biological activities; inhibits CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively); prevents AAPH-induced increases in erythrocyte ROS and MDA levels in a concentration-dependent manner; reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model at 1 mg/kg twice per day; inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in BALF in a mouse model of ovalbumin-induced chronic asthma at 0.5 mg/kg
Cayman Chemical ANTIBODY GSK923295 50mg
A potent inhibitor of CENP-E (Ki = 3.2 nM); causes mitotic cell cycle delay, leading to apoptosis in various cancer cell lines; induces apoptosis in cancer cells in mice bearing xenografts of COLO 205 cells
Cayman Chemical ANTIBODY GYY 4137 50mg
A water-soluble, slow-releasing H2S donor which demonstrates vasodilator and anti-hypertensive activity in hypertensive rats when given intravenously; also protects against endotoxic shock in rats, inhibiting pro-inflammatory signaling