Bioactive Small Molecules
Medchemexpress LLC Casticin (Vitexicarpin) | 479-91-4 | 374.34 | 25 MG
Casticin is a methoxylated flavonol isolated from *Vitex rotundifolia* with antimitotic and anti-inflammatory effects. It inhibits the activation of STAT3, a protein involved in cell growth and division.
- Inhibits proliferation of KB cells and LX2 cells.
- Induces apoptosis in L02 cells.
- Reduces viability of 786-O, YD-8, and HN-9 cells.
- Increases cleavage caspase-3 and PPAR.
- Diminishes levels of Bcl-xl, Bcl-2, IAP-1/-2, VEGF, MMP-9, and COX-2 proteins.
- Promotes apoptotic cell death in tumor cells.
- Enhances the effect of ionizing radiation in 786-O cells.
- Attenuates liver fibrosis induced by CCl4 or BDL in vivo.
Medchemexpress LLC (13E,15S)-15-hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid | 13345-51-2 | 1MG
(13E,15S)-15-hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid | 13345-51-2 | 1MG
Cayman Chemical ANTIBODY InO-8875 5mg
An adenosine A1 receptor agonist; binds to adenosine A1 receptors (Ki = 0.97 nM) and is >10,000-fold selective for adenosine A1 over A2 receptors; topical application reduces intraocular pressure in a rabbit model of ocular hypertension at 25 UG/eye; decreases atrial refractoriness and heart rate, as well as slows atrioventricuolar nodal conduction, in anesthetized rats from 1-50 UG/kg
Medchemexpress LLC Glurate (4-acetylbutyric acid) | 3128-06-1 | MFCD00004412 | 130.14 | 10 G
Glurate (4-acetylbutyric acid) is an acylating agent used in the development of antiviral compounds. It targets retroviruses such as herpes virus and HIV, and can also be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid.
- Acylating agent
- Used in development of antiviral compounds
- Targets retroviruses (herpes virus and HIV)
- Synthesis of acyclic nucleoside derivatives
- Synthesis of 5-hydroxyhexanoic acid
Apexbio Technology LLC Sabutoclax 1228108-65-3 5mg
Sabutoclax (CAS 1228108-65-3) is a small-molecule inhibitor targeting multiple anti-apoptotic proteins of the Bcl-2 family including Bcl-xL Bcl-2 Mcl-1 and Bfl-1 with IC50 values of 0 31 M 0 32 M 0 20 M and 0 62 M respectively Derived from apogossypolone sabutoclax exhibits high affinity for Bcl-xL (Kd 0 11 M) and enhanced membrane permeability relative to related analogs In cellular studies sabutoclax suppresses PC3 cell proliferation (EC50 0 13 M) and induces apoptosis in human BP3 cells (IC50 0 049 M) In M2182 xenograft mouse models sabutoclax significantly reduces tumor volume with nearly complete inhibition of tumor growth at a dose of 5 mg/kg Sabutoclax is utilized to investigate Bcl-2 family inhibition in cancer research
![Medchemexpress LLC 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | 1206711-16-1 | 99.8% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230139.png-250.jpg)
Medchemexpress LLC 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | 1206711-16-1 | 99.8% | 5 MG
DMH-1 (Standard) is an analytical standard of DMH-1, a selective bone morphogenetic protein (BMP) type I receptor inhibitor used as a reference in biochemical and cell-based assays. It exhibits IC50s of 27 nM (ALK1), 107.9 nM (ALK2), <5 nM (ALK3), and 47.6 nM (ALK6).
- Analytical standard for assay calibration and reference.
- Selective BMP type I receptor inhibitor targeting ALK1, ALK2, ALK3, and ALK6.
- Documented IC50s for ALK receptors support target-specific studies.
- High-purity solid suitable for analytical use (99.78% by supplier certificate).
- Available in small milligram quantities for research applications.
![Medchemexpress LLC N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolopyridin-3-yl)pyrimidin-2-amine | 1594092-37-1 | >98.0% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230144.png-250.jpg)
Medchemexpress LLC N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolopyridin-3-yl)pyrimidin-2-amine | 1594092-37-1 | >98.0% | 1 ML
AZ191 is a potent, selective small-molecule inhibitor of DYRK1B (IC50 = 17 nM) supplied for research use. It is typically provided as a concentrated solution (10 mM, 1 mL); refer to the datasheet for detailed solubility and storage guidance.
- Potent DYRK1B inhibitor with IC50 of 17 nM.
- High purity: ≥98% (HPLC).
- Chemical identifiers: CAS 1594092-37-1; formula C24H27N7O; MW 429.52 g/mol.
- Soluble in DMSO (≥30 mg/mL) and can be formulated for in vivo use.
- Storage recommendations: powder -20°C (up to 3 years); in solvent -80°C for long-term storage.
Medchemexpress LLC T-448 | 1597426-53-3 | 98.4% | 100 MG
T-448 is an orally active, irreversible inhibitor of lysine-specific demethylase 1 (LSD1) for research use. It inhibits LSD1 with an IC50 of about 22 nM, is supplied as a solid with high purity, and is DMSO-soluble with recommended in vivo formulation protocols.
- Irreversible LSD1 inhibitor with an IC50 of 22 nM.
- High purity solid suitable for biochemical and cellular studies.
- DMSO soluble (≈16.67 mg/mL) with recommended vehicle formulations for in vivo use.
- Available in multiple pack sizes, including 100 MG.
- Provided with supporting documentation such as SDS and COA.
Medchemexpress LLC NSC-87877 disodium | 56932-43-5 | 98.0% | 503.42 | 5 MG
NSC-87877 disodium is a potent inhibitor of protein tyrosine phosphatases, specifically Shp2 and Shp1, exhibiting IC50 values of 0.318 μM and 0.355 μM respectively. Additionally, this compound demonstrates inhibitory activity against dual-specificity phosphatase 26 (DUSP26). It has shown promising anti-neuroblastoma activity in animal models by inhibiting tumor growth, and in vitro studies indicate it induces p53-mediated apoptosis in various neuroblastoma cell lines. The product is intended for research use only.
- Potent inhibition of Shp2 and Shp1 protein tyrosine phosphatases.
- Inhibits dual-specificity phosphatase 26 (DUSP26).
- Demonstrates anti-neuroblastoma activity.
- Induces p53 phosphorylation and activation.
- Results in apoptosis in various cell lines.
- Suppresses neuroblastoma tumor growth in animal models.
Medchemexpress LLC Ozanimod | 1306760-87-1 | 98.0% | 500 MG
Ozanimod (RPC-1063) is a small-molecule sphingosine 1-phosphate (S1P) receptor modulator used as a research reference standard for studies of immune modulation and multiple sclerosis. It selectively binds S1P1 and S1P5 receptors and is supplied for analytical and in vitro research (CAS 1306760-87-1).
- Selective S1P1 and S1P5 receptor modulation
- Low-nanomolar in vitro potency
- Available as a solid reference standard in multiple sizes, including 500 mg
- Powder stable at -20°C for long-term storage
- 98% purity standard suitable for analytical use
Selleck Chemical LLC CA-5f 5mg 1370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Crocin | 42553-65-1 | 976.96 | 25 MG
Crocin (Standard) is an analytical standard of Crocin, intended for research and analytical applications. Crocin (Crocin I) is an orally active natural product isolated from the stigma of Crocus sativus. It demonstrates various biological activities, including the inhibition of tumor cell proliferation, promotion of apoptosis through the JAK pathway, and anti-inflammatory, antioxidant, and antitumor properties.
- Analytical standard for research and analytical applications
- Natural product isolated from Crocus sativus
- Inhibits tumor cell proliferation and promotes apoptosis
- Exhibits anti-inflammatory, antioxidant, and antitumor activities
- Used as a reference standard in qualitative, quantitative, and methodological research experiments
- Suitable for applications such as HPLC, GC, and MS
Cayman Chemical ANTIBODY SMU127 500ug
An agonist of TLR1/2; induces NF-κB signaling in cells expressing human TLR2 (EC50 = 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 from 0.1-100 µM; induces the production of TNF-α in isolated human PBMCs from 0.01-1 µM; reduces tumor volume in a 4T1 murine mammary carcinoma model at 0.1 mg/animal