Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,666 – 4,680 of 60,549 results

4,666

Medchemexpress LLC Polyvinylpyrrolidone K90 | 9003-39-8 | 98.0% | 5 G

Polyvinylpyrrolidone K90 | 9003-39-8 | 98.0% | 5 G

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4,667

Selleck Chemical LLC Trastuzumab MMAE-D4052-1MG-5

Trastuzumab MMAE is an antibody-drug conjugate (ADC) It is composed of monomethyl auristatin E (MMAE) and trastuzumab conjugated via a Vc (Valine citrulline) linker Trastuzumab MMAE has high affinity specificity and anti-tumor activity in vitro

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4,668

Cayman Chemical Mecillinam, Purity: ≥95%, CAS: 32887-01-7, 1 g

A β-lactam antibiotic; active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively); active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine; binds to PBP2 over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay; efficacious against susceptible E. coli strains in a systemic mouse model of infection (PD50s = ≤0.39-6.4 mg/kg)

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4,669

TARGETMOL CHEMICALS INC SJB3-019A 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SJB3-019A is a potent potent and novel ubiquitin-specific protease 1 (USP1) inhibitor which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043 with IC50 of 0.0781 uM. SJB3-019A inhibits cell proliferation and causes cell apoptosis. purity: 99%

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4,670

Cayman Chemical AZ82, Purity: ≥98%, CAS: 1449578-65-7, 5 mg

An inhibitor of KIFC1; binds to the KIFC1/microtubule complex and inhibits its microtubule-stimulated activity (IC50 = 300 nM) in an ATP-competitive (Ki = 43 nM) and microtubule-noncompetitive manner; does not inhibit basal KIFC1 activity at a concentration of 100 µM; selective for KIFC1 over a panel of nine kinesin motor proteins at a concentration of 5 µM; AZ82 preferentially induces multipolar spindle formation in cancer cell lines with high numbers of extra chromosomes

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4,671

AdipoGen trans-4,5-Dihydroxy-1,2-dithiane (1 g)

Chemical. CAS: 14193-38-5. Formula: C4H8O2S2. MW: 152.24. trans-4,5-Dihydroxy-1,2-dithiane (oxidized dtt) is an intramolecular disulfide form of dithiothreitol. Oxidized DTT exhibits a strong absorbance peak at 280 nm. It is a strong reducing agent with an ability to elicit a molecular stress response by activating the stress-responsive genes.

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4,672

Medchemexpress LLC 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile | 118409-62-4 | MFCD00236448 | 98.0% | 215.17 g·mol^-1 | C10H5N3O3 | 1 ML

AG126 (Tyrphostin AG126) is a small-molecule tyrosine kinase inhibitor that inhibits phosphorylation of ERK1 and ERK2 at approximately 25-50 μM. It is supplied for research use in solid form and as DMSO solutions, and is used in studies of meiosis, mitosis, and postmitotic cellular processes.

High purity: 98.0%.
Available as solid and as 10 mM solution in DMSO.
Chemical formula C10H5N3O3; molecular weight 215.17 g·mol⁻¹.
Appearance: light yellow to yellow solid.
Storage: powder -20 °C (up to 3 years) or 4 °C (up to 2 years); in solvent -80 °C (up to 2 years).

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4,673

Cayman Chemical LY2874455, Purity: ≥98%, CAS: 1254473-64-7, 5 mg

A pan-FGFR inhibitor (IC50s = 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively); inhibits proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor xenografts in mice

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4,674

Vector Biolabs Inhibitor of growth family member 2 Adenovirus (Ad-p33ING2)

Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA

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4,675

AdipoGen Forskolin (25 mg)

Chemical. CAS: 66575-29-9. Formula: C22H34O7. MW: 410.5. Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer’s disease symptoms and has also shown a number of antitumor effects.

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4,676

Cayman Chemical Notopterol, Purity: ≥95%, CAS: 88206-46-6, 5 mg

A furanocoumarin with diverse biological activities; a JAK2 and JAK3 inhibitor (IC50s = 9.51 and 25.2 µM, respectively); selective for JAK2 and JAK3 over TYK2 and JAK1 (IC50s = >667 and >2,000 µM, respectively); induces apoptosis and mitochondrial membrane depolarization in HL-60 cells at 40 and 60 µM; induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 10, 20, and 40 µM; decreases acetic acid-induced writhing and vascular permeability in mice at 100 mg/kg; increases the duration of pentobarbital-induced sleep in mice at 10 or 30 mg/kg; reduces joint swelling, inhibits decreased talus bone volume, and reduces meniscus and talus osteoclast numbers in a mouse model of collagen-induced arthritis at 20 mg/kg per day

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4,677

Cayman Chemical Dapivirine, Purity: ≥98%, CAS: 244767-67-7, 25 mg

A diarylpyrimidine derivative of the potent NNRTI efavirenz; inhibits HIV-1 reverse transcriptase (IC50= 24 nM: impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing

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4,678

Cayman Chemical 1-Palmitoyl-2-Oleoyl-3-Stearoyl-rac-glycerol, Purity: ≥98%, CAS: 2190-27-4, 5 mg

A triacylglycerol; one of the primary triacylglycerols found in cocoa butter

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4,679

Medchemexpress LLC Succinimide (pyrrolidine-2,5-dione) | 123-56-8 | 99.9% | 99.09 | 100 G

Succinimide (pyrrolidine-2,5-dione) rapidly hydrolyzes into aspartic acid during the reduction/alkylation process. It is utilized in the development of an antiepileptic agent.

Solid appearance
White to off-white color
Used in antiepileptic agent development

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4,680

Cayman Chemical Arctiin, Purity: ≥98%, CAS: 20362-31-6, 25 mg

The major active lignin in fruits of the burdock plant A. lappa that demonstrates potent antiviral, anti-inflammatory, and antiproliferative activity

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Bioactive Small Molecules

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Medchemexpress LLC Polyvinylpyrrolidone K90 | 9003-39-8 | 98.0% | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile | 118409-62-4 | MFCD00236448 | 98.0% | 215.17 g·mol^-1 | C10H5N3O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Succinimide (pyrrolidine-2,5-dione) | 123-56-8 | 99.9% | 99.09 | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Polyvinylpyrrolidone K90 | 9003-39-8 | 98.0% | 5 G

Medchemexpress LLC 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile | 118409-62-4 | MFCD00236448 | 98.0% | 215.17 g·mol^-1 | C10H5N3O3 | 1 ML

Medchemexpress LLC Succinimide (pyrrolidine-2,5-dione) | 123-56-8 | 99.9% | 99.09 | 100 G