Bioactive Small Molecules
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (1)
- (16)
- (2)
- (2)
- (2)
- (27)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (153)
- (2)
- (1)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (4)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (2)
- (5)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (1)
- (5)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (96)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (10)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (3)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (5)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (2)
- (2)
- (1)
- (52)
- (2)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (25)
- (9)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (63)
- (1)
- (2)
- (5)
- (271)
- (2)
- (4)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (7)
- (6)
- (1)
- (2)
- (2)
- (1)
- (3)
- (1)
- (91)
- (16)
- (8)
- (2)
- (9)
- (4)
- (2)
- (1)
- (3)
- (4)
- (2)
- (15)
- (2)
- (1)
- (10)
- (2)
- (4)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (1)
- (7)
- (1)
- (1)
- (7)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (3)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
Filtered Search Results
Medchemexpress LLC HY-15908 500mg Medchemexpress, BCA CAS:979-88-4 Purity:>98%
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Medchemexpress, HY-15908 500mg BCA CAS:979-88-4 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
STEMCELL Technologies SCR7, Size: 5 mg
SCR7 is an inhibitor of DNA ligase IV, which is responsible for the repair of DNA double-strandbreaks via the non-homologous end joining (NHEJ) repair pathway (Srivastava et al.). Due to its reported success in impeding cancer cell growth and potential impact on future cancer therapeutics, SCR7 has been closely studied in many recent publications (Hosoya & Miyagawa; John et al.). GENOME EDITING·Inhibits NHEJ-dependent DNA repair; this inhibition is reported to enhance precise homology-directed repair (HDR)-dependent CRISPR-Cas9 genome editing (Chu et al.; Maruyama et al.; Pinder et al.). However, these effects are cell type-specific and context-dependent (Song et al.; Xie et al.; Yang et al.; Zhang et al.).CANCER RESEARCH·Activates apoptosis of cancer cells by inhibiting DNA ligase IV to increase the efficacy of DNA double-strand break-inducing therapy (chemo- or radio-therapy) (Srivastava et al.).
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Endo CNTinh-03 | 345288-49-5 | 427.51 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Endo CNTinh-03 is an inhibitor designed to prevent the elevation of cyclic AMP (cAMP) and cyclic GMP (cGMP) that are typically induced by agonists like G protein-coupled receptors, adenylate cyclase, and guanylate cyclase.
- Inhibits cholera toxin-induced CFTR chloride current
- Inhibits Escherichia coli (STa) toxin-induced CFTR chloride current
- Ameliorates secretory diarrhea in mouse models
- Prevents cyst growth in polycystic kidney disease models
- Exhibits an IC50 of 4 μM against the elevation of cAMP and cGMP
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Go 6976, 25mg Cas# 136194-77-9
Go 6976 5mg. Go 6976 is a selective inhibitor of PKC with IC50 value of 20 nM [1] [2]. There are other sizes available. Please inqury us for quote.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC SL-327, 5mg. Cas: 305350-87-2 MFCD: MFCD06411432. Selective MEK1/2 inhibitor
SL-327 is a selective inhibitor of MEK1 and MEK2 with IC50 values of 0.18 and 0.22M, respectively.MEK1 and MEK2 (ERK) are a kinase enzyme which phosphorylate mitogen-activated protein kinase (MAPK). Other sizes are available. Please inqury us for quote.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Eflornithine (hydrochloride hydrate) | 96020-91-6 | 1 G
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. It is used as a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. This product also serves as an analytical standard for research and analytical applications.
- Specific, irreversible inhibitor of ornithine decarboxylase
- Used for treatment of African trypanosomiasis
- Used for excessive facial hair growth in women
- Functions as an analytical standard for research applications
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
AdipoGen PK150 (Sorafenib Analog) (5 mg)
Chemical. CAS: 2165324-62-7. Formula: C15H8ClF5N2O3. MW: 394.7. Analog of the anticancer drug sorafenib. PK150 is a potent antibiotic. It shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively. PK150 did not induce in vitro resistance and shows oral bioavailability and in vivo efficacy. The mode of action includes the interference with menaquinone biosynthesis by inhibiting demethylmenaquinone methyltransferase and the stimulation of protein secretion by altering the activity of signal peptidase IB.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Cayman Chemical LY2606368, Purity: ≥98%, CAS: 1234015-52-1, 10 mg
A Chk1 inhibitor (Ki = 0.9 nM); IC50 values of 2/M checkpoint in HeLa cells; induces apoptosis in gastric cancer cell lines
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC TSLP Human HEK293 2ug
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Recombinant human thymic stromal lymphopoietin (TSLP) produced in HEK293 cells with a C-terminal 10xHis tag. Supplied as a lyophilized powder, this cytokine is suitable for binding assays, functional ELISAs, and cell-based studies of TSLP-TSLPR signaling, and is provided with high purity and low endotoxin to support sensitive bioassays and reproducible results.
- High purity greater than 95% as determined by reducing SDS-PAGE.
- Glycosylated protein expressed in mammalian cells for native folding.
- Includes defined residues Y29-Q159 corresponding to the mature isoform.
- Lyophilized formulation for convenient storage and shipment.
- Low endotoxin (<1 EU/μg) suitable for cell-based assays.
- Demonstrated bioactivity with ED50 values in the ng/mL range.
- Stable when stored at -20°C and after reconstitution with an appropriate carrier protein.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
TARGETMOL CHEMICALS INC HSMG-1 INHIBITOR 11E 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment. purity: 98%
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Cayman Chemical PAP-1, Purity: ≥98%, CAS: 870653-45-5, 5 mg
An inhibitor of Kv1.3 channels (EC50 = 2 nM at -80 mV in cells overexpressing the human channel); selective for Kv1.3 over a panel of 22 ion channels (EC50s = 45-15,000 nM for all); inhibits anti-CD3 antibody-induced proliferation of isolated human CCR7- effector memory T cells; inhibits ovalbumin-induced delayed-type hypersensitivity in rats at 3 mg/kg
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Enzo Life Sciences D-(+)-Biotin (1g). CAS: 58-85-5
Alternative name: Vitamin H. Purity: ≥98% (HPLC). Solubility: Soluble in hot water, diluted acids and alkaline solutions; hardly soluble in cold water. Long Term Storage: +4°C.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Cayman Chemical E7449, Purity: ≥98%, CAS: 1140964-99-3, 5 mg
An inhibitor of PARP1, PARP2, and TNKS1/2 (IC50s = 1, 1.2, and 50-11 nM, respectively); selective for PARP1, PARP2, and TNKS1/2 over PARP3 and PARP6-15 (IC50s = >3 μM); inhibits growth of DT40 cells in a PARP-dependent manner (IC50s = 3.2 and >15 μM for wild-type and PARP-/- cells, respectively); decreases expression of Wnt/β-catenin signaling pathway proteins in SW480 cells; enhances antitumor activity of temozolomide and carboplatin in a B16/F10 isograft model and MX-1 mouse xenograft model, respectively; inhibits tumor growth in a BRCA1 mutant MDA-MB-436 breast cancer mouse xenograft model at 30 and 100 mg/kg per day; delays hair regrowth in mice following hair removal
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC 18β-Glycyrrhetyl-3-O-sulfate | 10251-38-4 | 98.0% | 550.75 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
18β-Glycyrrhetyl-3-O-sulfate is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 μM using rat kidney microsome. It is the major metabolite of glycyrrhetinic acid (GA) and a substrate of organic anion transporter (OAT) 1 and OAT3. This product exhibits anti-inflammatory effects and shows potential for pseudohyperaldosteronism research.
- Potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor
- IC50 of 0.10 μM using rat kidney microsome
- Major metabolite of glycyrrhetinic acid (GA)
- Substrate of organic anion transporter (OAT) 1 and OAT3
- Exhibits anti-inflammatory effects
- Potential for pseudohyperaldosteronism research
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Cayman Chemical MEP-FUBINACA, Purity: ≥98%, CAS: 2749985-46-2, 5 mg
An analytical reference standard that is structurally similar to known synthetic cbs; intended for research and forensic applications
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More