Bioactive Small Molecules
Cayman Chemical ANTIBODY PAz-PC 1mg
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.{9800} Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.{9891} PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.{10651}
Cayman Chemical ANTIBODY MCC-555 10mg
A structural homolog of rosiglitazone that binds PPARγ with about 1/10 the affinity of rosiglitazone yet is a more potent antidiabetic agent in whole animal experiments than rosiglitazone (ED50s = 2.7 mg/kg and 7.1 mg/kg, respectively)
Cayman Chemical ANTIBODY L67 50mg
A competitive inhibitor of DNA ligases (IC50s = 10 and 10 µM for human DNA ligase I and human DNA ligase IIIβ); blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents; inhibits mitochondrial DNA ligase IIIα and induces the production of ROS and apoptosis in cancerous, but not non-malignant, cells; does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM; cytotoxic in vitro
AdipoGen Opaganib
Chemical. CAS 915385-81-8. Formula C23H25ClN2O. MW 380.9. Opaganib is a selective inhibitor of sphingosine kinase 2 SPHK2 Ki = 9.8 μM, a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate S1P. S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-α signaling and other inflammatory cytokine production. By inhibiting the SK2 enzyme, opaganib blocks the synthesis of S1P which regulates fundamental biological processes such as cell proliferation, migration, immune cell trafficking and angiogenesis, and is also involved in immune-modulation and suppression of innate immune responses from T cells. Opaganip has similar potency toward sphingosine kinase SK2 and dihydroceramide desaturase DES1.
Medchemexpress LLC Pomalidomide-CO-C5-Br | 2227423-38-1 | 450.28 | 1 G
Pomalidomide-CO-C5-Br (Compound 6b) is a conjugated compound of the E3 ligand Pomalidomide and linker. It is designed for use in synthesizing highly effective PROTAC molecules.
- Conjugated compound of E3 ligand Pomalidomide and linker.
- Used to synthesize highly effective PROTAC molecules.
- Targets ADC.
Medchemexpress LLC A2AR-agonist-1 | 41552-95-8 | 99.9% | 410.43 | 1 MG
A2AR-agonist-1 is a potent A2AR agonist and ENT1 inhibitor with Ki of 4.39 and 3.47 for A2AR and ENT1. It is for research use only.
- Potent A2AR agonist
- ENT1 inhibitor
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Cloransulam-methyl | 147150-35-4 | 99.4% | 429.81 g/mol | C15H13ClFN5O5S | 1MG
Cloransulam-methyl is a triazolopyrimidine sulfonanilide herbicide supplied as an analytical standard for research and analytical applications. It acts as an acetolactate synthase (ALS) inhibitor and is used in herbicidal activity studies and residue analysis. The material is provided at high purity and packaged in small quantities appropriate for standards and method development.
- High purity suitable for analytical use (99.44%).
- Molecular formula C15H13ClFN5O5S, molecular weight 429.81 g·mol⁻¹.
- Intended for research and analytical applications, including residue analysis.
- Available in milligram pack sizes for preparing stock solutions.
- Soluble in DMSO for stock solution preparation.
- Certificate of analysis and safety data sheet available.
Cayman Chemical ANTIBODY LXH254 10mg
A pan-RAF inhibitor; selectively inhibits B-RAF and C-RAF over a panel of 456 human kinases; inhibits MAPK signaling in tumor cells expressing mutant B-RAFV600; induces tumor regression in various mouse xenograft models
Cayman Chemical ANTIBODY FlumequIn 1g
A fluoroquinolone antibiotic; active against S. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, and K. pneumoniae (MICs = 1-100 UG/ml); active against field isolates of B. hyodysenteriae (MICs = 6.25-200 UG/ml); increases survival in rat models of P. vulgaris-induced urinary tract infection and P. mirabilis-induced prostatitis at 50 mg/kg
AdipoGen Pazopanib . hydrochloride (250 mg)
Chemical. CAS: 635702-64-6. Formula: C21H23N7O2S . HCl. MW: 437.5 . 36.5. Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor. It is an orally available angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit. It inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay) and also inhibits PDGFR, FGFR, c-Kit and c-fms with IC(50) values of 84nM, 74nM, 140nM and 146nM, respectively, all key proteins responsible for tumor growth and angiogenesis. Pazopanib is an anti-tumor and anti-angiogenic agent. It inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells co-cultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.
AdipoGen Miglitol (10 mg)
Chemical. CAS: 72432-03-2. Formula: C8H17NO5. MW: 207.2. Anti-diabetic agent with antihyperglycemic activity. alpha-Glucosidase inhibitor. Inhibits lysosomal alpha-glucosidase, sucrase, maltase and isomaltase (IC50= 0.35, 0.11, 1.3, and 1.2µM, respectively) as well as maltase-glucoamylase (IC50 = 1.0µM). alpha-Glucosidase enzymes hydrolyze oligosaccharides and disaccharides into glucose and other monosaccharides. Inhibition by miglitol prevents the breakdown of larger carbohydrates into glucose. This suppresses postprandial hyperglycemia and reduces plasma glucose concentration in normal rats and in several animal models of diabetes without cardiovascular complications. Anti-obesity drug. Shown to inhibit adipogenesis of white adipocytes in vitro and to activate brown adipose tissue (BAT) in mice. Induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans.
Medchemexpress LLC C18 dihydroceramide | 2304-80-5 | MFCD01076443 | 99.0% | 567.97 g/mol | C36H73NO3 | 5 MG
C18 dihydroceramide is a saturated dihydroceramide (sphingolipid) used as a biochemical reagent and analytical standard in lipid research. The compound (CAS 2304-80-5) is supplied as a solid for use in biochemical assays, sphingolipid metabolism studies, and analytical method development. Storage recommendations: sealed at -20°C; in solvent, store at -80°C (up to 6 months) or -20°C (up to 1 month).
- High purity suitable for analytical and research applications.
- Molecular weight 567.97 g/mol.
- Molecular formula C36H73NO3.
- Provided as a 5 mg solid quantity.
- Storage conditions support long-term stability when frozen.
- Appropriate for sphingolipid metabolism and analytical method development.
Medchemexpress LLC Thiq | 312637-48-2 | MFCD09970598 | 98.5% | 589.17 | C33H41ClN6O2 | 10 MG
THIQ is a selective melanocortin-4 receptor (MC4R) agonist used in research to probe MC4R signaling and receptor trafficking. It functions as a pharmacoperone that can rescue cell-surface expression and signaling of certain intracellularly retained MC4R mutants and has been employed in rodent studies of erectile activity.
- Selective MC4R agonist with high affinity and potency (hMC4R IC50=1.2 nM; EC50=2.1 nM; rMC4R IC50=0.6 nM; EC50=2.9 nM).
- Acts as a pharmacoperone to restore receptor cell-surface expression.
- High reported purity and supplied as a solid, white to off-white material.
- Stable under recommended storage (powder: -20°C for 3 years; 4°C for 2 years).
- Suitable for in vitro and in vivo studies of melanocortin receptor biology.
Medchemexpress LLC N-Acetylpenicillamine | 15537-71-0 | MFCD00078887 | 98.0% | 191.25 | 10 G
N-Acetylpenicillamine is an N-acetyl-D-amino acid derived from D-penicillamine. It is intended for laboratory chemical applications and the manufacture of substances. This product is for research and development use only and must be handled by technically-qualified personnel.
- Derived from D-penicillamine
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
- For research and development use only
Medchemexpress LLC Dhodh-in-23 | 1346705-53-0 | C24H21CIFNO4 | 100 MG
DHODH-IN-23 is an orally active DHODH inhibitor that can be used for cancer research. It inhibits acute myeloid leukemia cell proliferation and induces CD11b expression in THP-1 cells. The compound has demonstrated significant antitumor activity in MV411 mouse xenograft models, both as a single agent and in combination with Cytarabine.
- Inhibits acute myeloid leukemia cells proliferation
- Induces CD11b expression in THP-1 cells
- Shows antitumor activity in MV411 mouse xenograft model as a single agent
- Shows antitumor activity in MV411 mouse xenograft model in combination with Cytarabine