Bioactive Small Molecules
Medchemexpress LLC COH29 | 1190932-38-7 | 98.8% | 420.44 | 100 MG
COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity, effective against various cancer cell lines including ovarian cancer and leukemia. It works by inhibiting the α and β subunits of RNR, and can overcome resistance to other cancer therapies like hydroxyurea and gemcitabine.
- Potent ribonucleotide reductase (RNR) inhibitor
- Exhibits anticancer activity
- Inhibits α and β subunits of RNR
- Overcomes hydroxyurea and gemcitabine resistance in cancer cells
- Effectively inhibits proliferation of most cell lines in NCI 60 human cancer panel
- Little effect on normal fibroblasts or endothelial cells
Medchemexpress LLC OVA Peptide(257-264) TFA | 1262751-08-5 | >99.9% | 1077.15 | 100 MG
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of ovalbumin. This octameric peptide is presented by the class I MHC molecule, H-2Kb, and is primarily intended for research use.
- Class I (Kb)-restricted peptide epitope
- Derived from ovalbumin
- Presented by the class I MHC molecule, H-2Kb
- Intended for research use
Medchemexpress LLC 18:1 Liss Rhod PE | 384833-00-5 | 99% | 1301.72 | 5 MG
18:1 Liss Rhod PE is a fluorescent phospholipid and probe designed for dip-pen nanolithography (DPN) phospholipid patterning research. It can be admixed into phospholipid inks for large-scale monitoring of lithographic structures via fluorescence microscopy. This probe allows for the quantitative correlation between the physical height of phospholipid membrane stacks and the number of membrane layers, aiding in the rapid characterization of three-dimensional topological information.
- Fluorescent phospholipid and probe.
- Admixes into phospholipid inks for monitoring lithographic structures.
- Enables large-scale, high-throughput microscopic imaging.
- Supports quantitative correlation between physical height and membrane layers.
- Facilitates rapid characterization of three-dimensional topological information.
- Undergoes phase separation or self-quenching in thin lipid membrane stacks under certain conditions.
Cayman Chemical C-87, Purity: ≥95%, CAS: 332420-90-3, 25 mg
An inhibitor of TNF-α; binds to TNF-α; inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 µM) in L-929 cells; reduces liver inflammation and injury, as well as increases survival, in a mouse model of LPS- and GalN-induced acute hepatitis at 12.5 mg/kg
Medchemexpress LLC Lei110 | 2313525-90-3 | 99.7% | 456.46 | C25H23F3N2O3 | 25MG
LEI110 is a small-molecule inhibitor of the HRASLS family of thiol hydrolases, including PLA2G16. It is cell-permeable and intended for research use in biochemical and cellular assays to probe phospholipase-related pathways; handle according to the safety data sheet and laboratory best practices.
- Potent inhibitor of HRASLS/PLA2G16 suitable for biochemical assays.
- Cell-permeable for use in cellular studies.
- High purity confirmed by HPLC (99.72%).
- Characterized by COA and SDS with formula C25H23F3N2O3 and molecular weight 456.46.
- Soluble in DMSO and recommended for storage under desiccated cold conditions.
- Available in small mass pack sizes appropriate for research applications.
Medchemexpress LLC Eriodictyol-7-O-glucoside | 38965-51-4 | 1 MG
Eriodictyol-7-O-glucoside is a flavonoid and a potent Nrf2 activator. It effectively scavenges hydroxyl radicals and superoxide anions and increases the nuclear localization of Nrf2, inducing the expression of Nrf2/ARE-dependent genes. This compound provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult and demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia. It is suitable for the study of stroke.
- Purity: 99.42%
- Molecular weight: 450.39
- Formula: C21H22O11
- Appearance: Solid
- Color: Off-white to light yellow
- Structure classification: Flavonoids, flavanones, phenols, polyphenols
- Increases Nrf2 protein level in a time-dependent and dose-dependent manner
- Does not affect Nrf2 mRNA level but induces mRNA of HO-1, NQO1, and GCLC
- Reduces oxygen and glucose deprivation (OGD)-induced cell death and intracellular ROS levels
Selleck Chemical LLC 10-Deacetyl-7-xylosyltaxol S0563-25MG
10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol 7-xylosyl-10-deacetylpaclitaxel) a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9
Selleck Chemical LLC H2DCFDA S9687-100MG
H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production It is de-esterified intracellularly and turns to highly fluorescent 2 7 -dichlorofluorescein upon oxidation It is used in sensitive and rapid quantitation of oxygen-reactive species in response to oxidative metabolism microplate assay for detecting oxidative products in phagocytic cells and quantitative multiwell myeloid differentiation assay (Ex/Em 488/525 nm)
Medchemexpress LLC Alkaline Phosphatase 10ug
ALPI Proteinas an alkaline phosphatase effectively hydrolyzes diverse phosphate compounds Alkaline Phosphatase/ALPI Protein Human (HEK293 His) is the recombinant human-derived ALPI protein expressed by HEK293 with C-His labeled tag
Selleck Chemical LLC Erlotinib HCl (OSI-744) 500mg 183319-69-9 CP358774, NSC 718781
Erlotinib HCl (OSI-744, CP358774, NSC 718781) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HPGDS inhibitor 2 | 2101626-26-8 | 99.7% | 378.41 g·mol⁻1 | C20H24F2N2O3 | 50MG
HPGDS inhibitor 2 is a potent, selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor for research use, with an in vitro IC50 of 9.9 nM. It is supplied as a high-purity solid and includes solubility and formulation data to support biochemical, cellular, and in vivo studies.
- Potent H-PGDS inhibition (IC50 9.9 nM).
- High purity (99.7%).
- Molecular weight 378.41 g·mol⁻1.
- Chemical formula C20H24F2N2O3.
- Soluble in DMSO at ≥150 mg/mL for in vitro applications.
- Formulation-ready for in vivo dosing at ≥2.5 mg/mL in common vehicles.
- Available as a 50 mg research quantity.
Cayman Chemical Eplerenone, Purity: ≥98%, CAS: 107724-20-9, 1 mg
An analytical reference standard categorized as a diuretic; has been detected as an AAF during anti-doping testing; intended for use in analytical forensic applications
Cayman Chemical ZLN024, Purity: ≥98%, CAS: 723249-01-2, 5 mg
An allosteric activator of AMPK heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively); reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice
Cayman Chemical Hemokinin 1 (human) (trifluoroacetate salt), Purity: ≥98%, 5 mg
A peptide agonist of NK1 receptors; induces migration of A375 and B16/F10 cells at 1 µM, an effect that can be reversed by L-732,138; promotes the proliferation, migration, and tube formation of HUVECs at 0.001-0.1 µM; induces the production of PGE2 in human colon mucosal and muscle explants; intracerebroventricular administration increases the latency to withdrawal in the tail-flick test in mice; decreases MAP and heart rate in anesthetized rats at 1-30 nmol/kg