Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical NSC 781406, Purity: ≥98%, CAS: 1676893-24-5, 1 mg
A dual inhibitor of PI3K and mTOR (IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively); inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM); reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model at 30 mg/kg
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Cayman Chemical PIK-293, Purity: ≥98%, CAS: 900185-01-5, 1 mg
A selective inhibitor of the PI3K catalytic subunit p110δ (IC50s = 0.24 µM)
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eMolecules 1094158-39-0 | Quinazoline-2,4-diol | AA Blocks LLC | MFCD00047588 | 162.148 | C8H6N2O2 | 0.000 | Oc1nc(O)c2ccccc2n1 | 1g | 913076892
Quinazoline-2,4-diol | AA Blocks LLC | 1094158-39-0 | MFCD00047588 | 162.148 | C8H6N2O2 | 0.000 | Oc1nc(O)c2ccccc2n1 | 1g | 913076892
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Selleck Chemical LLC Atamparib S8993-25MG
Atamparib (RBN-2397) is a potent selective and orally active NAD competitive inhibitor PARP7 with IC50 of 3 nM and Kd of 0 001 M RBN-2397 has the potential for the research of tumor treatment
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Selleck Chemical LLC eCF506 S0791-5MG
eCF506 is a potent selective and orally bioavailable inhibitor of Src tyrosine kinase with IC50 0 5 nM
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Apexbio Technology LLC SAR191801 1234708-04-3 10mM (in 1mL DMSO)
SAR191801 (CAS 1234708-04-3) is a selective inhibitor of human hematopoietic prostaglandin D synthase (hPGDS) By targeting and suppressing hPGDS enzymatic activity SAR191801 effectively reduces the synthesis of prostaglandin D (PGD ) In fluorescence polarization and enzyme immunoassay experiments it demonstrated an IC value of 12 nM for hPGDS inhibition SAR191801 serves as a valuable tool for studying physiological processes and pathologies mediated by PGD including allergic reactions inflammatory responses and sleep-wake regulation mechanisms
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Apexbio Technology LLC Imeglimin hydrochloride 775351-61-6 100mg
Imeglimin hydrochloride (CAS 775351-61-6) is a small molecule investigated as an oral agent for type 2 diabetes It acts by modulating mitochondrial function across hepatic muscular and pancreatic tissues In hepatocytes imeglimin redirects substrate flow towards complex II inhibits complex I restores complex III activity and enhances fatty acid oxidation which is supported by increased 3-hydroxyacyl-CoA dehydrogenase activity and acylcarnitine levels The compound also reduces reactive oxygen species and elevates mitochondrial DNA content In high-fat high-sucrose diet mouse models imeglimin improves glucose tolerance insulin sensitivity and mitochondrial function while normalizing metabolic parameters Currently imeglimin is under clinical evaluation both as monotherapy and in combination with other antidiabetic agents
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Medchemexpress LLC G3-C12 TFA | 99.4% | 1873.00 | 5 MG
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G3-C12 (TFA) is a galectin-3 binding peptide that exhibits anticancer activity with a Kd of 88 nM. It shows high affinity for galectin-3 but no affinity for other galectin family members or other lectins. When bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA), it potently and selectively targets colorectal cancer (CRC) tumor cells over-expressing galectin-3, demonstrating superior targetability to galectin-3 compared to galactose bearing copolymer.
- Galectin-3 binding peptide
- Kd of 88 nM
- Shows anticancer activity
- High affinity for galectin-3
- No affinity for other galectin family members or lectins
- Potently and selectively targets colorectal cancer (CRC) tumor cells over-expressing galectin-3 when conjugated with HPMA opolymers
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eMolecules 2097262-58-1 | Medchem Express | TVB-3664 | 5mg | 536983945 | HY-120062 | 468.48 | C25H23F3N4O2
Pharmablock | 4-iodopyridine-2-carboxylic acid | 100mg | 551337127 | PBZP2012001 | 405939-79-9 | MFCD03426666 | 249.007 | C6H4INO2
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Medchemexpress LLC GSK1521498 free base 50mg | 1007573-18-3 | 50 MG
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GSK1521498 free base is a potent, selective μ-opioid receptor (MOR) antagonist supplied for research use. It is used in neuroscience and pharmacology studies of opioid receptor-mediated behaviors, including compulsive consumption models. The material is provided as a solid with batch-specific analytical data.
- Potent, selective μ-opioid receptor antagonist.
- High analytical purity suitable for preclinical research.
- Provided as solid powder for convenient handling.
- Batch-specific certificate of analysis available.
- Supplied in small pack sizes for dosing and assay development.
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Medchemexpress LLC L-Seryl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-phenylalanyl-L-a-glutamyl-L-lysyl-L-leucine trifluoroacetate | 1262751-08-5 | 99.9% | 1077.15 | 25 MG
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OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA. This octameric peptide, derived from ovalbumin, can be presented by the class I MHC molecule, H-2Kb.
- Class I (Kb)-restricted peptide epitope of OVA.
- Octameric peptide derived from ovalbumin.
- Presented by the class I MHC molecule, H-2Kb.
- Protein context influences TAP-independent processing for MHC class I presentation.
- Presented with differential dependence on the TAP transporter.
- Contained within MBPCrl-OVA or Crl-OVA bacterial fusion proteins is presented with little dependence on the TAP transporter.
- Contained within full-length ovalbumin is largely dependent on the TAP transporter.
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Enzo Life Sciences CK-666 (2mg). CAS: 442633-00-3
Cell permeable inhibitor human (IC50=4µM), fission yeast (IC50=5µM), S. cerevisiae (IC50=12µM) and bovine (IC50=17µM) Arp2/3 complex between Arp2 and Arp3. Inhibits Listeria motility (IC50=7µM). Alternative name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide. Purity: ≥95%. Solubility: Soluble in DMSO (a minimum concentration of 5 mg/ml is recommended). Long Term Storage: -20°C.
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Medchemexpress LLC HY-77036 500mg Medchemexpress, Furagin CAS:1672-88-4 Purity:>98%
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Medchemexpress, HY-77036 500mg Furagin CAS:1672-88-4 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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TARGETMOL CHEMICALS INC OTSSP167 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. purity: 99%
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Cayman Chemical Cilofexor, Purity: ≥98%, CAS: 1418274-28-8, 10 mg
An FXR ligand; inhibits binding of a SRC-1-based synthetic peptide to FXR (EC50 = 50 = ≥100 nM)
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