Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,191 – 5,205 of 60,541 results

5,191

Cayman Chemical 8-Methoxymethyl-3-isobutyl-1-methylxanthine, Purity: ≥98%, CAS: 78033-08-6, 5 mg

A PDE1 inhibitor (IC50 = 5 µM); selective for PDE1 over PDE2, PDE3, and PDE4 but also inhibits PDE5 (IC50s = 37, >400, >400, and 2 µM, respectively); enhances forskolin-induced increases in intracellular calcium levels in isolated rat olfactory receptor neurons at 30 µM; induces relaxation of isolated human saphenous vein segments in the absence of endothelium (EC50 = 31 µM); enhances iloprost-induced decreases in pulmonary artery pressure and vascular resistance in a rabbit model of U-46619-induced pulmonary hypertension at 200 µg/kg

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5,192

Medchemexpress LLC BCA-1/CXCL13 Mouse 100ug | 100ug

CXCL13 known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant) is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor[1] CXCL13 is a homeostatic chemokine and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles) such as spleen lymph nodes tonsils and Peyer s patches[2] BCA-1/CXCL13 Protein Mouse (HEK293 Fc) is produced in HEK293 cells with a N-Terminal Fc-tag It consists of 88 amino acids (I22-A109)

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5,193

Cayman Chemical LCS3, Purity: ≥98%, CAS: 109844-92-0, 1 mg

An inhibitor of GR and TrxR (IC50s = 3.3 and 3.8 µM, respectively); decreases the GSH/GSSG ratio in NCI H1650 and H23 lung adenocarcinoma cells; induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells at 3 µM; active against M. tuberculosis (MIC = 0.098 µM)

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5,194

Medchemexpress LLC Monensin methyl ester | 28636-21-7 | 99.18% | 25 MG

Monensin methyl ester is a neutral analog of Monensin that functions as an ion active component for Na+ selective disk electrodes. It is intended for research use only.

Neutral analog of Monensin
Functions as an ion active component for Na+ selective disk electrodes
Suitable for laboratory research

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5,195

Apexbio Technology LLC Latrepirdine, 5mg. Cas: 97657-92-6 MFCD: MFCD01617545. Brain cell death inhibitor

Latrepirdine is an orally active, small molecule compound that has been shown to inhibit brain cell death in animal models of Alzheimer's disease and Huntington's disease. Research suggests it may also have cognition-enhancing effects in healthy individua Other sizes are available. Please inqury us for quote.

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5,196

Medchemexpress LLC AIMP2-DX2 inhibitor | 2421117-98-6 | 99.8% | 546.66 | 1 ML

BC-DXI-843 is a potent and selective inhibitor that targets AIMP2-DX2, demonstrating an IC50 of 0.92 μM in a luciferase assay. This compound exhibits over 100-fold selectivity against AIMP2, making it a promising candidate for anti-cancer therapy, particularly in lung cancer. It effectively suppresses cancer cell proliferation in a DX2-dependent manner and shows efficacy in in vivo tumor models without significant changes in body weight, indicating its potential for specific therapeutic applications.

Potent and selective inhibition of AIMP2-DX2.
High selectivity over AIMP2.
Potential as a lead compound for lung cancer therapy.
Suppresses cancer cell proliferation in a DX2-dependent manner.
Demonstrates in vivo efficacy in tumor xenograft models.

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5,197

Medchemexpress LLC (Rac)-Hexestrol-d4 | 1189950-25-1 | 1 MG

(Rac)-Hexestrol-d4 is the deuterium labeled (Rac)-Hexestrol. It is intended for research use only and is not sold to patients. This compound can be utilized as a tracer and as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes like deuterium into drug molecules is primarily for quantitation during the drug development process, as deuteration can influence the pharmacokinetic and metabolic profiles of drugs.

Can be used as a tracer.
Can be used as an internal standard for quantitative analysis.
Incorporation of stable heavy isotopes into drug molecules for quantitation.
Deuteration can influence pharmacokinetic and metabolic profiles.

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5,198

Apexbio Technology LLC RBC8 361185-42-4 50mg

RBC8 (CAS 361185-42-4) is a selective small-molecule inhibitor of Ral GTPases targeting both RalA and RalB which are Ras-related GTPases implicated in tumor growth and metastasis In cellular assays RBC8 suppresses Ral-dependent NSCLC cell lines H2122 and H358 with IC50 values of 3 4 M and 3 5 M respectively In live cells RBC8 reduces RalA activity and selectively inhibits cellular spreading in wild-type mouse embryonic fibroblasts (MEFs) but not in CAV1-deficient MEFs In vivo daily intraperitoneal administration of RBC8 significantly inhibits tumor growth in H2122 and H358 xenografts RBC8 is a valuable research tool for elucidating Ral GTPase-mediated pathways in cancer biology

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5,199

Cayman Chemical Cyproconazole, Purity: ≥98% (mixture of isomers), CAS: 94361-06-5, 5 mg

A triazole fungicide; reduces mycelial growth of A. mellea on grapevine roots; reduces defoliation of rose plants induced by D. rosae; Lethal to C. riparius and D. tigrina (LC50s = 17.46 and 47.38 mg/L in tank water, respectively); induces liver hypertrophy and fat vacuolation, as well as induces hepatocellular adenoma and carcinoma formation, in mice

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5,200

Cayman Chemical Iodixanol, Purity: ≥95% (mixture of isomers), CAS: 92339-11-2, 1 mg

A contrast reagent; induces apoptosis and mitophagy in renal epithelial cells in a rat model of contrast-induced acute kidney injury; has been used as a density gradient medium in the fractionation of plasma lipoproteins

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5,201

Cayman Chemical BAY-218, Purity: ≥98%, CAS: 2162982-11-6, 10 mg

An AhR antagonist (IC50 = 39.9 nM); decreases AhR nuclear translocation induced by aflatoxin B1 in L-02 hepatocytes and TK6 lymphoblasts when preincubated at 1 µM; reduces tumor growth in a CT26 mouse xenograft model at 30 mg/kg alone and in combination with an anti-PD-L1 antibody

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5,202

Cayman Chemical methyl-1-(cyclohexylmethyl)-1H-indole-3-Carboxylate, Purity: ≥98%, CAS: 858515-82-9, 5 mg

An analog of BB-22 that lacks the quinoline group; intended for forensic and research applications

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5,203

Selleck Chemical LLC Eptifibatide Acetate 50mg 148031-34-9 Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2

Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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5,204

Cayman Chemical ANTIBODY 6-PPD-Q 25mg

An oxidized derivative of 6-PPD; toxic to rainbow trout and brook trout (LC50s = 0.59 and 1.96 UG/L, respectively) but not to arctic char and white sturgeon (LC50s = >12.7 UG/L for both); induces cell death and germline DNA damage, as well as decreases the number of mitotic cells, in C. elegans gonads at 10 UG/L; urine levels are increased in pregnant women compared to non-pregnant adults and children

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5,205

Cayman Chemical Cefprozil, Purity: ≥95% (mixture of cis and trans), CAS: 92665-29-7, 25 mg

A cephalosporin antibiotic; inhibits the growth of both Gram-positive and Gram-negative bacteria; inhibits the growth of E. coli, E. faecalis, E. faecium, N. gonorrhoeae, N. meningitidis, P. mirabilis, S. aureus, S. pyogenes, and S. pneumoniae strains (MICs = 0.013-25 μg/ml) and clinical isolates of penicillin-susceptible, -intermediate, and -resistant S. pneumoniae and methicillin-sensitive S. aureus (MIC90s = 0.12-16 μg/ml); protects mice challenged with E. coli, S. aureus, S. pyogenes, and P. mirabilis strains (PD50s = 0.07-1.3 mg/kg)

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Bioactive Small Molecules

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Medchemexpress LLC BCA-1/CXCL13 Mouse 100ug | 100ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Monensin methyl ester | 28636-21-7 | 99.18% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AIMP2-DX2 inhibitor | 2421117-98-6 | 99.8% | 546.66 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (Rac)-Hexestrol-d4 | 1189950-25-1 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BCA-1/CXCL13 Mouse 100ug | 100ug

Medchemexpress LLC Monensin methyl ester | 28636-21-7 | 99.18% | 25 MG

Medchemexpress LLC AIMP2-DX2 inhibitor | 2421117-98-6 | 99.8% | 546.66 | 1 ML

Medchemexpress LLC (Rac)-Hexestrol-d4 | 1189950-25-1 | 1 MG