Bioactive Small Molecules
Medchemexpress LLC Radioprotectin-1 100mg | 1622006-09-0 | 100 MG
Radioprotectin-1 is a small-molecule, nonlipid agonist selective for the lysophosphatidic acid receptor 2 (LPA2). It is supplied for research use and is used in vitro for receptor activation studies and pharmacology research; the reported EC50 for murine LPA2 is 25 nM.
- Potent LPA2 agonist with reported EC50 25 nM (murine).
- Suitable for in vitro receptor activation and signaling studies.
- High reported purity for reliable experimental results.
- Available in multiple small research pack sizes for assay work.
TARGETMOL CHEMICALS INC TILIQUINOL 25MG
Also available in 50 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Tiliquinol (NSC-130828) (NSC-130828) is a non-absorbed luminal agent with anti-amoebic properties that is often used in conjunction with tibroquinol. It is commonly employed in the study and investigation of amebic liver abscesses. purity: 99%
Enzo Life Sciences Pifithrin-alpha (cyclic). hydrobromide (10mg). CAS: 60477-34-1
Stable analog of pifithrin-α (BML-GR325), with biological properties similar to its parent compound, but with reduced cytotoxicity. Inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Potent STAT6 transcriptional inhibitor. Increases apoptosis in target cells when used in combination with antimicrotubule agents. Formula: C16H16N2S . HBr. MW: 268.4 . 80.9. Purity: ≥95% (HPLC, TLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO (100mg/ml). Long Term Storage: -20°C. Handling: Protect from light and moisture. Keep under inert gas.
STEMCELL Technologies SBI-0206965, Size: 10 mg
SBI-0206965 is an inhibitor of the autophagy initiator kinases ULK1 and ULK2 (IC₅₀ = 108 nM and 711 nM, respectively; Egan et al.). SBI-0206965 is also a potent inhibitor of AMP-activated protein kinase (AMPK), a positive regulator of autophagy (Dite et al.). CANCER RESEARCH· Synergizes with mTOR inhibition to induce apoptosis and cell death in tumor cells (Egan et al.).· Suppresses autophagy induced by mTOR inhibition (Egan et al.).· Suppresses prosurvival autophagic responses in tumor cells through AMPK and ULK1 inhibition (Dite et al.).
Cayman Chemical BTZ043, Purity: ≥98%, CAS: 1161233-85-7, 1 mg
An antibiotic with antimycobacterial activity; targets mycobacterial cell wall synthesis by inhibiting DprE1; active against various Mycobacterium species in vitro, including M. smegmatis, M. bovis, and M. tuberculosis (MICs = 4, 2, and 1 ng/ml, respectively), as well as the actinobacterium N. brasiliensis (MIC50 = 0.125 μg/ml); active against M. tuberculosis in RAW 264.7 murine macrophages (MIC = M. tuberculosis cells in lung and spleen in a mouse model of chronic tuberculosis infection at 37.5 or 300 mg/kg for four weeks
Cayman Chemical Foxy-5 (trifluoroacetate salt), Purity: ≥98%, 5 mg
A Wnt5a peptide mimetic with anticancer activity; increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells from 1-1,000 µM; reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model at 2 mg/kg
Apexbio Technology LLC Suprofen, 10mg. Cas: 40828-46-4 MFCD: MFCD00079572. dual COX-1/COX-2 inhibitor
Suprofen is a non-steroidal anti-inflammatory drug (NSAID). Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Thiazolo[5,4-f]quinazoline-2-carboximidic acid, 9-[(2-fluoro-4-methoxyphenyl)amino]-, methyl ester | 1425945-60-3 | 98.9% | 383.40 | 50 MG
EHT 1610 is a potent inhibitor of DYRK, with IC50s of 0.36 nM (DYRK1A) and 0.59 nM (DYRK1B). It exhibits antileukemia effect, regulates cell cycle, and induces cell apoptosis.
- Induces apoptosis of primary ALL cells that were resistant to cytarabine.
- Dose-dependently induces apoptosis in B- and T-cell lines and primary human pediatric cells.
- Inhibits DYRK1A, leading to a loss of DYRK1A-mediated FOXO1 and STAT3 signaling, resulting in preferential cell death in leukemic B cells.
- Inhibits phosphorylation of FOXO1, STAT3, and cyclin D3, regulating late cell-cycle progression, mitochondrial ROS, and DNA damage.
- Demonstrates antileukemia activity in a leukemic aggressive model in mice, reducing leukemic burden and conferring a modest survival advantage.
Medchemexpress LLC Laquinimod-d5 | 1214267-09-0 | 98.3% | 361.83 g/mol | C19H12D5ClN2O3 | 5 MG
Laquinimod-d5 is a deuterium-labeled analogue of laquinimod provided for research use as an analytical reference and internal standard. It is intended for isotope-labeling studies, quantitative mass spectrometry, and method development in neurodegeneration and immunomodulation research. Supplied as a high-purity powder, it supports accurate tracing and quantitation in analytical workflows.
- Deuterium-labeled internal standard for mass spectrometry quantitation.
- High purity (98.3%) suitable for analytical applications.
- Consistent molecular composition (C19H12D5ClN2O3) for reproducible results.
- Available in small milligram quantities for method development.
- Recommended powder storage at -20°C to preserve stability.
TARGETMOL CHEMICALS INC PA-8 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective effective and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo. purity: 97%
Medchemexpress LLC HY-15847 5mg Medchemexpress, HS38 CAS:1030203-81-6 Purity:>98%
Medchemexpress, HY-15847 5mg HS38 CAS:1030203-81-6 HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-135331 1mg Medchemexpress, N-Desmethyl-Apalutamide CAS:1332391-11-3 Purity:>98%
Medchemexpress, HY-135331 1mg N-Desmethyl-Apalutamide CAS:1332391-11-3 N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Homatropine methylbromide | 80-49-9 | 98.0% | 10 MM * 1 ML
Homatropine methylbromide is a muscarinic AChR antagonist. It inhibits muscarinic receptors in both endothelial and smooth muscle, with IC50 values of 162.5 nM and 170.3 nM in WKY-E and SHR-E, respectively. It has been shown to prevent lethality in a rat model of acute organophosphate poisoning.
- Muscarinic AChR antagonist
- Inhibits endothelial and smooth muscle muscarinic receptors
- IC50 values of 162.5 nM (WKY-E) and 170.3 nM (SHR-E)
- Produces a dose ratio of 259 in atrium from guinea-pigs (20 μM)
- Comparable to atropine in preventing lethality in a rat model of acute organophosphate poisoning (20 mg/kg)
- Molecular Weight: 370.28
- Formula: C17H24BrNO3
- Appearance: Solid, white to off-white
Medchemexpress LLC BTT-266 10mg | 2413939-89-4 | 10 MG
BTT-266 is a small-molecule calcium channel antagonist that suppresses the CaVα1-AID-CaVβ3 interaction (reported Ki = 1.4 μM). It is provided as a high-purity powder for biochemical and pharmacological research on voltage-dependent calcium channels.
- High purity (98.90%) powder for research use.
- Molecular weight 556.61 and formula C34H28N4O4.
- Soluble in DMSO at 12.5 mg/mL; sonication may be required.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).
- Suitable for biochemical assays and calcium channel modulation studies.
TARGETMOL CHEMICALS INC JNJ-31020028 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07 human; pIC50=8.22 rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. purity: 96%