Bioactive Small Molecules
Cayman Chemical ANTIBODY Cy7 25mg
A cyanine-containing fluorochrome; ex/em = 745/800 nm, respectively
Medchemexpress LLC TC-G 1005 | 1415407-60-1 | 99.34% | 399.48 | 10 MG
TC-G 1005 is a potent, selective, and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively. It can reduce glucose levels in vivo.
- Activates human and mouse TGR5 with EC50s of 0.72 nM and 6.2 nM, respectively.
- Stimulates GLP-1 secretion in ICR mice.
- Causes a 49% reduction in blood glucose AUC0-120 min in ICR mice.
- Significantly reduces blood glucose at 4, 6, 10, and 24 hours in db/db mice.
- Exhibits low plasma exposure in rats with a Cmax of 56 ng/mL and a t1/2 of 1.5 hours.
- Appearance: Solid.
- Color: Off-white to yellow.
- Storage: Powder: -20°C for 3 years, 4°C for 2 years. In solvent: -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC BMS-509744 | 439575-02-7 | 98.1% | 623.83 | 50 MG
BMS-509744 is a potent, selective, and ATP-competitive Itk inhibitor with an IC50 of 19 nM. This compound reduces T-cell receptor-induced functions, including PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion, and T-cell proliferation in vitro in both human and mouse cells. It has also been shown to significantly diminish lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.
- Potent Itk inhibitor
- Selective and ATP competitive
- Reduces T-cell receptor-induced functions (e.g., PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion, T-cell proliferation)
- Diminishes lung inflammation in mouse models of allergy/asthma
Cayman Chemical ANTIBODY PsoralIdIn 5mg
A furanocoumarin isolated from the seeds of P. corylifolia that has been shown to induce cytotoxicity against various cancer cells through TRAIL-mediated events
Cayman Chemical ANTIBODY d-1001b 10mg
An inhibitor of mutant IDH1 (IC50s = 15 and 130 nM for IDH1R132H and IDH1R132C, respectively); selective for mutant IDH1 over wild-type IDH1 and IDH2, as well as IDH2R140Q and IDH2R172Q (IC50s = >10,000 nM for all); inhibits 2-HG production in TF-1 cells stably transfected with IDH1R132H or IDH1R132C (IC50s = 29 and 35 nM, respectively) and in 293A cells transiently transfected with IDH1R132H or IDH1R132C (IC50s = 29 and 42 nM, respectively); reduces tumor growth, as well as intratumoral and plasma 2-HG levels, in a subcutaneous IDH1R132H-expressing A1074 PDX mouse model of glioblastoma
Medchemexpress LLC Reutericycline | 303957-69-9 | 98.1% | 349.46 | C20H31NO4 | 25 MG
Reutericyclin is a tetramic-acid antibiotic produced by Lactobacillus reuteri and supplied as a research reagent for antimicrobial and biochemical studies. It has formula C20H31NO4 and a molecular weight of 349.46 g/mol. Supplied as a 25 mg solid, the compound is highly pure and soluble in DMSO for in vitro and in vivo formulation use.
- Tetramic-acid antibiotic for antimicrobial research.
- High purity suitable for biochemical and cellular assays.
- Provided as a small solid quantity for bench-scale experiments.
- Readily soluble in DMSO; ultrasonic agitation recommended.
- Includes in vivo formulation protocols for suspension preparations.
- Stable when stored as powder at -20°C for long-term storage.
Medchemexpress LLC EML 425 | 1675821-32-5 | 98.0% | 440.49 | 10 MG
EML 425 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively. It is a cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases, binding both the free enzyme and the enzyme-substrate complex. This compound induces a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9 in U937 cells.
- Potent and selective CREB binding protein (CBP)/p300 inhibitor
- IC50s of 2.9 μM for CBP and 1.1 μM for p300
- Cell-permeable
- Selective
- Noncompetitive versus both acetyl-CoA and a histone H3 peptide
- Induces a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9 in U937 cells
- Alternative binding pocket near the substrate lysine binding groove and close to the acetylation site
- Appearance: Solid
- Color: Light yellow to yellow
Cayman Chemical PIcralIma nItIda AkuamIn 5mg
An indole alkaloid with analgesic activity; selectively binds the μ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively); inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively); increases the latency to withdrawal in the tail-flick or hot plate test in mice at 60 mg/kg
Cayman Chemical ANTIBODY SGC-CBP30 50mg
A potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and 38 nM, respectively)
Medchemexpress LLC HY-100015 25mg , Mivebresib CAS:1445993-26-9 Purity:>98%
HY-100015 25mg Mivebresib CAS: 1445993-26-9 Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY 2 5-DmA 50mg
A natural triterpene which stimulates wound healing induces cell cycle arrest and apoptosis in breast cancer cells (IC50 5.9 UM for MCF-7 cells) blocks angiogenesis in glioblastomas down regulates BACE1 while increasing ADAM10 maturation in primary rat cortical neurons protects against neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice
Cayman Chemical ANTIBODY LoratdIn 25mg
A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs (ED50 = 0.40 mg/kg)
Medchemexpress LLC HY-18312 5mg , PF-4618433 CAS:1166393-85-6 Purity:>98%
HY-18312 5mg PF-4618433 CAS: 1166393-85-6 PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-144835 5mg , FHD-286 CAS:2671128-05-3 Purity:>98%
HY-144835 5mg FHD-286 CAS: 2671128-05-3 FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 3,4-difluorobenzamide | 85118-04-3 | MFCD00015549 | 1g
Baroxavir impurity 17 is an impurity of Baroxavir (HY-109025A)