Bioactive Small Molecules
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Filtered Search Results
![Medchemexpress LLC 2-(4-(4-((7-(3,5-difluorobenzyl)-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)acetamide | 909561-15-5 | 97.0% | C25H25F2N7O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260222.png-250.jpg)
Medchemexpress LLC 2-(4-(4-((7-(3,5-difluorobenzyl)-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)acetamide | 909561-15-5 | 97.0% | C25H25F2N7O | 10MG
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AS1810722 is an orally active small-molecule inhibitor of STAT6 used in preclinical research to study Th2-mediated signaling and allergic disease models. It potently inhibits STAT6 (IC50 ≈ 1.9 nM), reduces IL-4 production, and has shown activity in both cell-based differentiation assays and animal models of allergic asthma.
- Potent STAT6 inhibition with low-nanomolar IC50.
- Inhibits IL-4 production, modulating Th2 responses.
- Active in in vitro Th2 differentiation assays.
- Reduces eosinophil infiltration in animal models of allergic asthma.
- Suitable for both in vitro and in vivo preclinical studies.
- Stable as a powder with recommended cold-storage conditions.
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Cayman Chemical ProstaglndIn F2a Alcohol 5mg
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PGF2α-OH is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol. Biological studies on rat uterus show it to be a weak agonist.{7477} The compound is reported to retain ocular hypotensive properties,{7418} but the nature of the receptors which mediate these effects is disputed.{9585}
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Sigma Aldrich Fine Chemicals Biosciences MK6-83 >=98% (HPLC) | 1062271-24-2 | 25MG
MK6-83 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 336.47 | 1062271-24-2 | 25MG
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Sigma Aldrich Fine Chemicals Biosciences S0859 >=98% (HPLC) | 1019331-10-2 | 25MG
S0859 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 530.04 | 1019331-10-2 | 25MG
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Sigma Aldrich Fine Chemicals Biosciences Arbidol hydrochloride >=98% (HPLC) | 131707-23-8 | 50MG
Arbidol hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 513.88 | 131707-23-8 | 50MG
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Sigma Aldrich Fine Chemicals Biosciences Entacapone >=98% (HPLC) | 130929-57-6 | 50MG
Entacapone >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 305.29 | 130929-57-6 | 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000194110 SIGLEC-10 CYNOMOLGU 5UG
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Medchemexpress LLC Tnf-α-in-6 | 2699704-20-4 | 99.6% | C26H25N9O2 | 10MG
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TNF-α-IN-6 is a small-molecule, orally active allosteric inhibitor of tumor necrosis factor alpha (TNF-α) reported to bind TNF with high affinity (KD = 6.8 nM) and to exhibit anti-inflammatory effects in animal models. Manufacturer datasheet lists formula C26H25N9O2 and molecular weight 495.54 g·mol⁻¹; in vivo oral dosing (0, 10, 30, 100 mg/kg, twice daily, 17 days) reduced paw swelling in mice.
- Allosteric inhibitor of TNF-α.
- High affinity binding (KD = 6.8 nM).
- Demonstrated anti-inflammatory activity in vivo.
- Active orally with defined dosing regimens in animal studies.
- Soluble ≥2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline vehicle.
- Chemically defined: formula C26H25N9O2; MW 495.54 g·mol⁻¹.
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Medchemexpress LLC Ginsenoside Rh2 | 78214-33-2 | 622.87 | 25 MG
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Ginsenoside Rh2 is a promising candidate for anti-tumor drug development, promoting cancer cell apoptosis through multiple pathways by activating caspase-8 and caspase-9. It triggers p53-dependent Fas expression and subsequent activation of caspase-8, as well as a p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.
- Induces activation of caspase-8 and caspase-9.
- Promotes cancer cell apoptosis in a multi-path manner.
- Triggers p53-dependent Fas expression.
- Activates p53-independent caspase-9-mediated intrinsic pathway.
- Exhibits cytotoxic activity in various human tumor cell lines.
- Shown to reduce tumor sizes and increase survival in animal models.
- Purity of 99.28%.
- Appears as a white to off-white solid.
- Derived from natural sources (Panax ginseng C. A. Meyer).
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Medchemexpress LLC L-Valine-15N | 59935-29-4 | 118.14 | 25 MG
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L-Valine-15N is the 15N-labeled L-Valine, a nonlinear semiorganic material. It causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria, and inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase. This product is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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Medchemexpress LLC Morin | 480-16-0 | MFCD22573212 | 302.24 | 25 MG
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Morin | 480-16-0 | MFCD22573212 | 302.24 | 25 MG
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Medchemexpress LLC Crocin | 42553-65-1 | 976.96 | 25 MG
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Crocin (Standard) is an analytical standard of Crocin, intended for research and analytical applications. Crocin (Crocin I) is an orally active natural product isolated from the stigma of Crocus sativus. It demonstrates various biological activities, including the inhibition of tumor cell proliferation, promotion of apoptosis through the JAK pathway, and anti-inflammatory, antioxidant, and antitumor properties.
- Analytical standard for research and analytical applications
- Natural product isolated from Crocus sativus
- Inhibits tumor cell proliferation and promotes apoptosis
- Exhibits anti-inflammatory, antioxidant, and antitumor activities
- Used as a reference standard in qualitative, quantitative, and methodological research experiments
- Suitable for applications such as HPLC, GC, and MS
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Selleck Chemical LLC Marlea platanifolia Extract E3007-5MG
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Marlea platanifolia Extract is extracted from Marlea platanifoli that exhibits anti-inflammatory and analgesic activities
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Selleck Chemical LLC Acetylthiocholine iodide E2998-50MG
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Acetylthiocholine iodide(S-Acetylthiocholine iodide ATCh iodide) is used as a substrate in the preparation of acetylcholine esterase (AChE) assay working solution for AChE activity assay In addition the compound is used in some medical research for example in the fields of neuroscience and organ physiology
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Selleck Chemical LLC Jujubae Fructus Extract E3131-5MG
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Jujubae Fructus Extract is extracted from fruit of Ziziphus jujuba Mill which provides an effective treatment for chronic constipation and type 2 diabetes
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