Bioactive Small Molecules
Medchemexpress LLC N-sec-butyl Pentylone (hydrochloride) | 17763-05-2 | 99.0% | 313.82 | 1 MG
N-sec-butyl Pentylone hydrochloride is a drug derivative intended for research use only and not for sale to patients. It appears as a solid, white to off-white substance.
- Drug derivative
- For research use only
- Not sold to patients
- Solid, white to off-white appearance
- Ships at room temperature in continental US (may vary elsewhere)
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC Vt-1598 | 2089320-99-8 | 99.9% | 584.52 g·mol⁻¹ | C31H20F4N6O2 | 100MG
VT-1598 is a tetrazole-based, orally active, selective inhibitor of fungal sterol 14α-demethylase (CYP51) used as a research compound to evaluate antifungal activity. The compound has formula C31H20F4N6O2, molecular weight 584.52 g·mol⁻¹, CAS 2089320-99-8, and is supplied as a powder at high purity for laboratory studies.
Medchemexpress LLC ELR510444 | 1233948-35-0 | 98.0% | 368.47 | 25 MG
ELR510444 is a novel microtubule disruptor that inhibits MDA-MB-231 cell proliferation and exhibits potent antitumor activity. It is not a substrate for the P-glycoprotein drug transporter, maintaining activity in βIII-tubulin-overexpressing cell lines, thereby circumventing drug resistance. This compound also shows potential antivascular effects by decreasing HIF-1α and HIF-2α levels, reducing renal cell carcinoma (RCC) cell viability and clonogenic survival, and inducing apoptosis to significantly reduce tumor burden in RCC xenograft models. For research use only.
- Inhibits MDA-MB-231 cell proliferation with an IC50 of 30.9 nM
- Circumvents drug resistance mechanisms by not being a P-glycoprotein substrate
- Demonstrates potent antitumor activity in MDA-MB-231 xenograft model
- Exhibits potential antivascular effects
- Reduces renal cell carcinoma (RCC) cell viability and induces apoptosis
Cayman Chemical ANTIBODY ThymIdIn 5g
A pyrimidine nucleoside; oral administration in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency
Medchemexpress LLC PDGF-AA Human His 2ug
Recombinant human PDGF-AA protein with an N-terminal 6xHis tag, supplied as a lyophilized powder. Expressed in E. coli, the protein is biologically active in fibroblast proliferation assays (ED50 ≈ 53.4 ng/mL) and is intended for research into cell proliferation, migration, and wound healing.
- Expressed in E. coli.
- Contains N-terminal 6xHis tag for detection and purification.
- Lyophilized for long-term storage and convenient reconstitution.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Low endotoxin (<1 EU/μg) suitable for cell-based assays.
- Demonstrated biological activity (ED50 ~53.4 ng/mL in NIH-3T3 assay).
- Store lyophilized at -20°C; aliquot and freeze for extended storage.
Cayman Chemical ANTIBODY AZD 3965 10mg
A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport; increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts
Medchemexpress LLC Rotigotine impurity 1 | 244239-68-7 | 233.31 g/mol | 500mg
Rotigotine impurity 1 is an impurity of Rotigotine (HY-75502)
Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 25 MG
Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP), demonstrating an IC50 of 8 nM in vitro.
- Inhibits microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
- Reduces plasma concentrations of low density lipoprotein cholesterol (LDL-C) and triglycerides.
- Indicated for the treatment of Homozygous Familial Hypercholesterolemia (HoFH).
- Metabolized via cytochrome P-450 (CYP) isoenzyme 3A4.
- Bioavailability of 7.1% and a mean half-life of 39.7 hours for the 50-mg capsule.
- Exhibits antiproliferative activity against human HepG2 cells.
- Appears as a solid, white to off-white substance.
Cayman Chemical CD-5721353 5mg
A Bcl-6 inhibitor (Ki = 147 µM); selective for Bcl-6 over Kaiso, HIC1, and PLZF at 50 µM; cytotoxic against SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 DLBCL cells (GI50s = 0.024-0.936 mM); increases expression of ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 µM; reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Medchemexpress LLC HY-12942 10mg , PF-05175157 CAS:1301214-47-0 Purity:>98%
HY-12942 10mg PF-05175157 CAS: 1301214-47-0 PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CCR2 antagonist 4 | 226226-39-7 | 100.0% | 439.86 g/mol | C21H21ClF3N3O2 | 1 ML
CCR2 antagonist 4 (Teijin compound 1) is a research-grade small-molecule antagonist of the CC chemokine receptor 2 (CCR2). It selectively inhibits CCR2b (reported IC50 ≈ 180 nM) and potently blocks MCP-1-induced chemotaxis in cellular assays (reported IC50 ≈ 24 nM). The compound is supplied as a solid or as a ready-to-use DMSO stock (10 mM in 1 mL) for in vitro and in vivo studies.
- Potent CCR2b antagonist (IC50 ≈ 180 nM).
- Inhibits MCP-1-induced chemotaxis in cellular assays (IC50 ≈ 24 nM).
- Available as a DMSO stock solution for convenient in vitro dosing.
- Suitable for pharmacology and chemotaxis research applications.
- Molecular formula C21H21ClF3N3O2; molecular weight 439.86 g/mol.
Medchemexpress LLC NSC 107512 | 22242-89-3 | MFCD32671351 | 100.0% | C12H16N6O5 | 10MG
NSC 107512 is a sangivamycin-like small molecule inhibitor of cyclin-dependent kinase 9 (CDK9). It exhibits anti-proliferative activity and induces apoptosis in multiple myeloma models. This compound is supplied for laboratory research use only.
- Potent CDK9 inhibitor with a sangivamycin-like scaffold.
- Demonstrated to inhibit cell growth and induce apoptosis in multiple myeloma models.
- High supplied purity (99.97%).
- Molecular formula C12H16N6O5; molecular weight 324.29 g/mol.
- Available as small-mass solid packs and as DMSO solution formats for convenience.
- Suitable for long-term storage at -20°C (solid) and -80°C (in solvent) to preserve stability.
Medchemexpress LLC (S,S)-Gne 5729 | 2026636-06-4 | MFCD34676612 | 99.7% | 428.20 g/mol | C17H10Cl2F3N5O | 25 MG
(S,S)-Gne 5729 is the (S,S)-enantiomer of the small-molecule compound GNE 5729. Supplied as a solid research chemical, it is intended for biochemical and pharmacological research, stereochemistry-specific studies, analytical characterization, and synthetic chemistry applications.
- High enantiomeric purity suitable for stereospecific assays.
- Verified molecular formula and molecular weight for analytical work.
- Available in small-mass packaging appropriate for discovery-stage research.
- Provided with safety documentation and an SDS for laboratory handling.
Medchemexpress LLC Org 48762-0 50mg | 755753-89-0 | 50 MG
Org 48762-0 (UR13870) is a potent, orally active, and selective p38 MAP kinase inhibitor used in research to study inflammatory signaling and cytokine production. It inhibits p38α kinase with low-nanomolar potency in biochemical assays and reduces LPS-induced TNFα release in cellular and animal models.
- Potent p38α/p38β inhibition (EC50 0.1 μM).
- Reduces LPS-induced TNFα release in PBMCs (EC50 0.06 μM).
- Orally bioavailable with demonstrated systemic exposure in mice.
- High reported purity suitable for biochemical and cellular assays.
- Stable as a powder at -20°C for long-term storage.
Medchemexpress LLC 5-propargylamino-dCTP | 115899-39-3 | MFCD28010326 | 99.5% | C12H19N4O13P3 | 10MG
5-Propargylamino-dCTP is an alkyne-functionalized deoxycytidine triphosphate designed for enzymatic incorporation into DNA and for subsequent covalent labeling via click chemistry. The terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for attachment of probes or tags used in detection, sequencing, and imaging workflows.
- Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Designed for enzymatic incorporation into DNA as a dCTP analog.
- Enables post-synthetic conjugation of fluorescent probes or affinity tags.
- High purity for reliable biochemical performance.
- Soluble in water to facilitate aqueous labeling reactions.
- Suitable for nucleic acid labeling, sequence analysis, and probe development.