Bioactive Small Molecules
Cayman Chemical Aspartame, Purity: ≥98%, CAS: 22839-47-0, 50 g
A synthetic non-caloric sweetener; metabolized to phenylalanine, aspartic acid, and methanol in the gut; increases plasma ALT and AST activity, induces hepatocyte degeneration and leukocyte infiltration in the liver, and reduces hepatic levels of GSH, GSSG, and γ-GC in mice at 80 mg/kg per day for 90 days
Medchemexpress LLC Fluopyram technical | 658066-35-4 | 99.8% | 100MG
Fluopyram technical | 658066-35-4 | 99.8% | 100MG
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | 3079412-59-9 | C43H40N10O6 | 100 MG
PROTAC BCR-ABL Degrader-1 is a PROTAC with a 2-oxoethyl linker. It functions by inducing Bcr-Abl degradation through a ubiquitin-proteasome-dependent mechanism. This compound demonstrates antiproliferative activity against K562 cells, indicating its potential for use in cancer research.
- Induces Bcr-Abl degradation
- Functions in a ubiquitin-proteasome-dependent manner
- Exhibits antiproliferative activity against K562 cells
- Potential for cancer research
- Features a 2-oxoethyl linker
Cayman Chemical L-778,123, Purity: ≥95%, CAS: 183499-57-2, 10 mg
A dual inhibitor of FTase and GGTase I (IC50s = 2 and 98 nM, respectively); inhibits prenylation of FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively); inhibits prenylation of the oncogenic protein Ki-Ras in PSN-1 cells in a concentration-dependent manner; reduces HDJ2 and Rap1a prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day; has no effect on Ki-Ras prenylation in patient-derived PBMCs; inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s = 6.48 and 84.1 μM, respectively); inhibits IL-2-induced proliferation of CTLL2 cells (IC50 = 0.81 μM)
Medchemexpress LLC Violanthin | 40581-17-7 | 5 MG
Violanthin, isolated from the stems of *Dendrobium officinale*, exhibits potent antioxidant and antibacterial activities. It acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 79.80 μM. This compound is intended for research use only.
- Molecular weight: 578.52
- Formula: C27H30O14
- Appearance: Solid
- Color: White to yellow
- Structure classification: Flavonoids, flavones, phenols, polyphenols
- Initial source: Plants (Orchidaceae, Dendrobium officinale Kimura et Migo)
- Exhibits potent antioxidant activity
- Exhibits antibacterial activities
- Inhibits acetylcholinesterase (AChE)
Cayman Chemical DCP-Rho1, Purity: ≥98%, CAS: 1001575-98-9, 1 mg
A fluorescent probe for sulfenic acid-containing proteins; ex/em = 560/581 nm, respectively; has been used to visualize protein oxidation sites in situ
Medchemexpress LLC IDH1 Inhibitor 7 | 2135309-56-5 | C22H24F3N7O | 5 MG
IDH1 Inhibitor 7 (Compound 88) is a potent IDH1 inhibitor with an IC50 of less than 100 nM. It is a white to off-white solid with a molecular weight of 459.47 and is soluble in DMSO at 100 mg/mL. This compound is intended for research use only.
- IC50 of less than 100 nM against IDH1
- Appears as a white to off-white solid
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC HIV-1 inhibitor-45 | 2677762-43-3 | C23H24N4O8S | 5 MG
HIV-1 inhibitor-45 is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. It exhibits antiviral activity but shows poor cell permeability.
- Potent HIV-1 RNase H inhibitor
- IC50 value of 0.067 μM
- Shows antiviral activity
- Poor cell permeability (apparent permeability coefficient (Papp) lower than 0.48 x 10-6 cm/s)
- Low toxicity with a CC50 value of 24.7 μM in MT-4 cells
- Poor membrane permeability attributed to its polyphenolic skeleton
Medchemexpress LLC Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) | 65147-06-0 | 99.2% | 730.81 | 10 MG
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is a fluorogenic peptide substrate specific for activated factor X (FXa), utilized in the determination of Factor VIII. This compound presents as a white to off-white solid.
- Fluorogenic peptide substrate
- Specific for activated factor X (FXa)
- Used for Factor VIII determination
- White to off-white solid appearance
- Ships at room temperature in continental US
- Store sealed, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Etelcalcetide hydrochloride | 1334237-71-6 | 99.8% | 1353.33 | 100 MG
Etelcalcetide hydrochloride is a synthetic calcimimetic that activates the calcium sensing receptor (CaSR). It is effective in lowering parathyroid hormone (PTH) concentrations in dialysis patients with secondary hyperparathyroidism, showing promise for research in secondary hyperparathyroidism and chronic kidney disease.
- Activator of the calcium sensing receptor (CaSR)
- Effective in lowering parathyroid hormone (PTH) concentrations
- Promising for research in secondary hyperparathyroidism and chronic kidney disease
- Reduces parathyroid hormone (PTH) levels in human parathyroid cells
- Significantly reduces plasma PTH concentrations in animal models
TARGETMOL CHEMICALS INC MS0124 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM respectively. purity: 99%
Medchemexpress LLC Cecropin A (TFA) | 80451-04-3 | >98% | 4003.78 (free base) | 10 MG
Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. It exhibits anti-bacterial, anti-inflammatory, and anti-cancer activity.
- Induces cytotoxicity on HL-60 cells in a dose-dependent manner and induces apoptosis independent of caspase activation.
- Shows good antibacterial activity against multidrug-resistant Gram-negative bacteria such as *A. baumanii* and multidrug-resistant *P. aeruginosa*.
- Exhibits anti-inflammatory activities, effectively suppressing the expression of mTNF-a, mIL-1β, and mMIP-2 mRNA.
- Slightly inhibits the expression of mMIP-1 mRNA.
- Effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduces the expression of COX-2.
Cayman Chemical 1-(3-Fluorophenyl)piperazine (hydrochloride), Purity: ≥98%, CAS: 76835-10-4, 5 mg
A piperazine whose physiological and toxicological properties are not known
Medchemexpress LLC Neolinustatin | 72229-42-6 | C17H29NO11 | 5 MG
Neolinustatin is a cyanogenic glycoside that can be isolated from flaxseeds.
- Purity of 99.74%
- Molecular weight of 423.41
- Appearance as a solid
- Color from white to light yellow
- Classified as other structure
- Initially sourced from plants Linaceae Linum usitatissimum Linn.
- Shipping at room temperature in continental US (may vary elsewhere)
- Storage: 4°C (sealed, away from moisture and light); in solvent: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light).
Medchemexpress LLC L-theanine (standard) | 3081-61-6 | C7H14N2O3 | 50 MG
L-Theanine (Standard) is the analytical standard of L-Theanine, a non-protein amino acid found in green tea leaves. Intended for research and analytical applications, it blocks the binding of L-glutamic acid to glutamate receptors in the brain. This compound possesses neuroprotective, anticancer, and anti-oxidative activities, and is orally active with the ability to cross the blood-brain barrier.
- Used as an analytical standard and reference for assays
- Ideal for qualitative, quantitative, and methodological research (e.g., HPLC, GC, MS)
- Exhibits neuroprotective, anticancer, and anti-oxidative activities
- Blocks L-glutamic acid binding to glutamate receptors
- Orally active and can cross the blood-brain barrier