Bioactive Small Molecules
Medchemexpress LLC HY-114419A 5mg , Zetomipzomib (maleate) CAS:2170983-62-5 Purity:>98%
HY-114419A 5mg Zetomipzomib (maleate) CAS: 2170983-62-5 Zetomipzomib (KZR-616) maleate, a first-in-class immunoproteasome inhibitor, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. Zetomipzomib maleate has the potential for the research of multiple autoimmune diseases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Serpin F1 Human HE 50ug
Recombinant human PEDF/Serpin F1 protein, expressed in HEK293 cells with an N-terminal His tag and supplied lyophilized for research use. The protein is active in cell-based adhesion assays and is provided with low endotoxin to support sensitive biological experiments.
- Recombinant human PEDF/Serpin F1 expressed in HEK293 cells.
- N-terminal His tag for detection and purification.
- Lyophilized formulation for long-term storage.
- Low endotoxin level (<1 EU/μg) suitable for cell assays.
- Active in Saos-2 cell adhesion assay (ED50 0.2506 μg/mL).
- Supplied as a 50 μg aliquot; recommended storage at -20°C.
Enzo Life Sciences SB202190. hydrochloride (5mg). CAS: 350228-36-3
A water soluble form of the potent p38 (SAPK2a) inhibitor SB202190 (BML-EI294). Alternative name: FHPI . HCl, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole . HCl. Formula: C20H14FN3O . HCl. MW: 331.3 . 36.5. Purity: ≥96% (HPLC). Appearance: Yellow solid. Solubility: Soluble in water, methanol or DMSO. Long Term Storage: -20°C. Handling: Protect from light.
Medchemexpress LLC Bazedoxifene N-oxide | 1174289-22-5 | MFCD24386601 | 5mg
Bazedoxifene N-Oxide is the oxidative degradation product of selective estrogen receptor modulator (SERM) Bazedoxifene[1]
Cayman Chemical ANTIBODY Aspalaton 10mg
An anti-platelet aggregator (IC50 = 180 µM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism; at 24 mg/kg, generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus
Medchemexpress LLC AZD-1678 | 942137-41-9 | 98.1% | 352.17 | 10 MG
AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6. It is intended for research use only.
- Potent CCR4 receptor antagonist
- pIC50 of 8.6
Medchemexpress LLC Amifampridine (3,4-Diaminopyridine) | 54-96-6 | MFCD00006401 | >99.9% | 109.13 | 25 G
Amifampridine (3,4-Diaminopyridine) is an orally active, potent, and cell-permeable voltage-gated potassium (Kv) channel blocker (PCB). It is effective in reversing BoNT/A intoxication and increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research.
- Orally active, potent, and cell-permeable voltage-gated potassium (Kv) channel blocker.
- Effective in reversing BoNT/A intoxication.
- Increases transmitter release from neuromuscular junctions (NMJs).
- Used for research related to Lambert-Eaton myasthenic syndrome (LEMS).
Medchemexpress LLC MS31 (trihydrochloride) | 2748239-18-9 | 98.0% | 450.83 g/mol | C20H30Cl3N3O2 | 100MG
MS31 trihydrochloride is a fragment-like small-molecule inhibitor of the methyllysine reader protein Spindlin 1 (SPIN1), supplied as the trihydrochloride salt for research use. The compound exhibits low-nanomolar affinity for SPIN1 and is provided as a white to off-white solid with high purity suitable for biochemical and binding assays.
- High purity (98.0%) suitable for biochemical studies.
- Molecular weight 450.83 g/mol and formula C20H30Cl3N3O2.
- Demonstrated SPIN1 activity: AlphaLISA IC50 77 nM; FP IC50 243 nM; Kd 91 nM.
- Soluble in DMSO at 62.5 mg/mL (138.63 mM); ultrasonic assistance recommended.
- Stable as powder at 4°C; solutions stable at -80°C (6 months) or -20°C (1 month) when sealed.
- Available in multiple pack sizes, including 100 mg, for assay development and screening.
Apexbio Technology LLC DMNPE-caged ATP diammonium salt 10mg
DMNPE-caged ATP diammonium salt is a photo-sensitive ATP derivative designed to enable precise spatial and temporal control of ATP availability It achieves this by chemical modification of ATP with a DMNPE moiety which transiently suppresses its biological activity DMNPE-caged ATP exerts its bioactivity via rapid photolytic cleavage of the DMNPE group upon ultraviolet illumination restoring functional ATP Based on these properties DMNPE-caged ATP diammonium salt is employed as a tool in biological research fields such as cellular energetics ATP-dependent signaling pathway studies enzymatic regulation investigations and functional assays of ion channels
Medchemexpress LLC TLR3 Human HEK293 20ug | 20ug
The TLR3 protein is a key Toll-like receptor family member that plays an important role in the innate immune system s recognition of pathogen-associated molecular patterns especially viral double-stranded RNA Its research enhances understanding of immune responses and provides potential applications for vaccine development and antiviral treatments TLR3 Protein Human (HEK293 His) is the recombinant human-derived TLR3 protein expressed by HEK293 with C-His labeled tag
Selleck Chemical LLC Estramustine E4897-25MG
Estramustine(NSC-89201 LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules hinders microtubule assembly and promotes the disassembly of MAP-2-associated microtubules
Cayman Chemical BIs 2chloroIsopropyl ether 5mg
A byproduct in the synthesis of ethylene and propylene glycol; has been found in municipal drinking water in the United States and waterways in the Netherlands where it is considered a POP; mutagenic in the S. typhimurium strains TA 1535 and TA 100
Cayman Chemical ANTIBODY TAK-063 50mg
A potent inhibitor of PDE10A (IC50 = 0.3 nM); >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM; increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice when administered at a dose of 0.3 mg/kg; reverses PCP-induced hyperlocomotion (MED = 0.3 mg/kg, p.o.) in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg; reverses (+)-MK-801-induced hyperlocomotion (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats
Cayman Chemical -3 ArachIdonIc AcId 5mg
ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders.{5525} In human platelet membranes, ω-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a Ki of 14 µM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC50 value of about 5 µM.{2166}
Cayman Chemical DMAPPamonIum salt 5mg
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}