Bioactive Small Molecules
Medchemexpress LLC Klotho-derived peptide 1 hydrochloride | 98.6% | 3228.44 | 5 MG
Klotho-derived peptide 1 hydrochloride (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction and inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK). It exhibits anti-fibrotic and kidney protective effects in a mouse model and is intended for research use only.
- Blocks TGF-β/TGF-β receptor 2 interaction
- Inhibits TGF-β-induced activation of Smad2/3 and MAPK
- Exhibits anti-fibrotic effects
- Provides kidney protective effects
- Useful in inflammation and immune system disease research
- Applicable in stem cell/Wnt, TGF-beta/Smad, and MAPK/ERK pathway studies
Cayman Chemical ANTIBODY ButeIn 1mg
A plant polyphenol that is classified as a chalcone; a potent antioxidant that affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response
Medchemexpress LLC HY-108166A 1mg Medchemexpress, Hydroxystilbamidine bis(methanesulfonate) CAS:223769-64-0 Purity:>98%
Medchemexpress, HY-108166A 1mg Hydroxystilbamidine bis(methanesulfonate) CAS:223769-64-0 Hydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 4MethylthIoNbenzylcathInon 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Medchemexpress LLC Nonapeptide-1 | 158563-45-2 | 98.74% | 1206.50 | 5 MG
Nonapeptide-1, also known as Melanostatine-5, is a peptide hormone acting as a selective antagonist of MC1R (Ki: 40 nM). It functions as a competitive α-MSH antagonist, effectively inhibiting intracellular cAMP and melanosome dispersion in melanocytes induced by α-MSH (IC50: 2.5 nM and 11 nM, respectively). This compound is valuable in research concerning skin pigmentation, regulation of steroid production in the adrenal gland, and skin cancer studies due to its ability to inhibit melanin synthesis.
- Selective MC1R antagonist
- Potently inhibits intracellular cAMP and melanosome dispersion
- Inhibits melanin synthesis
- Useful for skin pigmentation research
- Applicable in studies of adrenal gland steroid regulation
- Relevant to skin cancer research
Medchemexpress LLC Gabapentin enacarbil | 478296-72-9 | 95.0% | 329.39 | 25 MG
Gabapentin enacarbil is a prodrug of Gabapentin, designed for absorption throughout the intestine by high-capacity nutrient transporters. Gabapentin is an orally active P/Q type Ca2+ channel blocker. It can be used to study Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
- Prodrug design for improved absorption.
- Potent, orally active P/Q type Ca2+ channel blocker.
- Research applications for restless legs syndrome (RLS) and postherpetic neuralgia (PHN).
- Improved bioavailability in rats and monkeys.
- Enhanced properties including increased dose proportionality and colonic absorption.
- Stable at physiological pH but rapidly converts to gabapentin in intestinal and liver tissue.
Medchemexpress LLC Gabapentin enacarbil | 478296-72-9 | 95.0% | 329.39 | 200 MG
Gabapentin enacarbil is a prodrug of Gabapentin designed for absorption throughout the intestine by high-capacity nutrient transporters. Gabapentin is an orally active P/Q type Ca2+ channel blocker. It is used for the study of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
- Demonstrates active apical to basolateral transport across Caco-2 cell monolayers.
- Stable at physiological pH and rapidly converted to gabapentin in intestinal and liver tissue.
- In rats, >95% of an oral dose is excreted in urine in 24 h as gabapentin.
- In monkeys, oral bioavailability of gabapentin from gabapentin enacarbil capsules was 84.2%.
- Improved gabapentin bioavailability, dose proportionality, and enhanced colonic absorption.
Selleck Chemical LLC Enitociclib S8730-100MG
Enitociclib (BAY 1251152) is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9 thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins
Medchemexpress LLC TRPM7-IN-1 | 1909225-07-5 | 98.8% | 419.48 | 5 MG
TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. It induces cell cycle arrest and apoptosis, and decreases the migration of MCF-7 and BGC-823 cells. It also decreases vimentin expression and increases E-cadherin expression. This compound potentially reduces TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway, making it a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function.
- Effective TRPM7 inhibitor.
- Induces cell cycle arrest and apoptosis.
- Decreases migration of MCF-7 and BGC-823 cells.
- Decreases vimentin expression and increases E-cadherin expression.
- Potentially reduces TRPM7-like current and decreases TRPM7 expression via the PI3K/Akt signaling pathway.
- Potential agent to suppress metastasis of breast and gastric cancer.
Medchemexpress LLC ZLC491 | 3053716-46-1 | 98.5% | 866.98 | 5 MG
ZLC491 is an orally active PROTAC degrader that selectively targets CDK12/CDK13. It induces cereblon- and proteasome-dependent selective degradation of CDK12 and CDK13, inhibiting the transcription and expression of long genes, and mainly acts on a subset of DNA damage response genes. ZLC491 also inhibits the proliferation of various triple-negative breast cancer cells.
- Selectively targets CDK12/CDK13.
- Orally active PROTAC degrader.
- Induces cereblon- and proteasome-dependent degradation.
- Inhibits transcription and expression of long genes.
- Acts on a subset of DNA damage response genes.
- Inhibits proliferation of triple-negative breast cancer cells.
- Exerts synergistic effect when combined with Cisplatin or Olaparib.
- Shows extremely low activity against non-cancer cell lines.
- Oral bioavailability of 46.8%.
![Medchemexpress LLC Benzeneacetamide, N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-2,6-dichloro- | 2055601-42-6 | 99.9% | 485.77 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000394406.png-250.jpg)
Medchemexpress LLC Benzeneacetamide, N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-2,6-dichloro- | 2055601-42-6 | 99.9% | 485.77 | 5 MG
P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with an IC50 of 15 nM. It is for research use only and not sold to patients. This compound demonstrates antagonist activity at human P2X4 receptor transfected in HEK293 cells. The product is suitable for various applications including compound screening and cellular effect assays.
- Molecular weight: 485.77
- Formula: C20H15Cl3N2O4S
- CAS number: 2055601-42-6
- Appearance: Solid, white to off-white
- Target: P2X4 receptor, with an IC50 of 15 nM
- Applications: Compound screening libraries (Immunology/Inflammation, Membrane Transporters/Ion Channels, Neurotransmitter Receptors, Bioactive Compound Libraries)
- Applied in cellular effect assays with HEK293 cell lines to assess inhibition of Bz-ATP-induced calcium influx
Medchemexpress LLC 2,5-Dihydroxy-1,4-benzoquinone | 615-94-1 | 99.95% | 140.09 | 1 G
2,5-Dihydroxy-1,4-benzoquinone (DHBQ) is a redox-active quinone-based organic ligand with antibacterial activity, obtainable from fungal metabolites. It can be used to construct conductive metal-organic frameworks for Li+-ion batteries and enhances Li+-ion battery cathode discharge capacity when incorporated into the Fe (dhbq) metal-organic framework.
- Redox-active quinone-based organic ligand
- Exhibits antibacterial activity
- Originates from fungal metabolites
- Enhances Li+-ion battery cathode discharge capacity
- Used to construct conductive metal-organic frameworks for Li+-ion batteries
- Functions as a redox-active cathode material for lithium-ion batteries (LIBs)
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | >99.46% | 419.45 | 5 MG
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. This compound is valuable for research into immune modulation and the activity of cancer stem cells.
- Potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator
- Useful for immune modulation research
- Assists in modulation of cancer stem cell activity research
Abcam GSK 4716, ERRbetagamma agonist, 10MG
MW 282.34 g/mol, Purity >99%. Selective ERRβ/γ agonist. Displays selectivity for ERRβ/γ over ERRα/β as well as other classical estrogen receptors. ERRβ is transiently induced and ERRγ is dramatically induced in vitro. Cell-permeable. Increases glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 mRNA in vitro..
The product is subject to the following: Abcam Restricted Use Statement