Bioactive Small Molecules
Medchemexpress LLC HY-A0077 500mg Medchemexpress, Perphenazine CAS:58-39-9 Purity:>98%
Medchemexpress, HY-A0077 500mg Perphenazine CAS:58-39-9 Perphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
STEMCELL Technologies Compound E, Size: 1 mg
Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.). DIFFERENTIATION· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Medchemexpress LLC Acrivastine | 87848-99-5 | HY-B1510 | 99.9% | 25 MG
Acrivastine is a short-acting histamine 1 receptor antagonist used for the treatment of allergic rhinitis. It is an effective and well-tolerated antihistamine, demonstrating superior efficacy to placebo and comparable results to other common antihistamines in treating chronic urticaria and seasonal allergic rhinitis.
- Short-acting histamine 1 receptor antagonist
- Effective in treating chronic urticaria and allergic rhinitis
- Causes less drowsiness compared to clemastine
- Reduces symptoms such as sneezing, runny nose, watery eyes, and itchy throat
- Well tolerated
STEMCELL Technologies Prostaglandin E2, Size: 5 mg
Prostaglandin E₂ (PGE₂) is the most biologically active and well-studied prostaglandin. It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively). (Abramovitz et al., Bos et al.)MAINTENANCE AND SELF-RENEWAL· Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.).· Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al. 2013, North et al.).DIFFERENTIATION· Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al., North et al., Woods et al.).· Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.).· Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.).
Medchemexpress LLC EPOR-CD131 Heterodim 2ug
The EPOR Protein functions as a receptor for erythropoietin mediating erythroblast proliferation and differentiation upon EPO stimulation The heterodimer triggers the JAK2/STAT5 signaling cascade and in certain cell types activates STAT1 STAT3 and the LYN tyrosine kinase Additionally isoform EPOR-T acts as a dominant-negative receptor modulating EPOR-mediated signaling pathways EPOR-CD131 Heterodimer Protein Human (HEK293 Fc) is a recombinant protein dimer complex containing human-derived EPOR-CD131 Heterodimer protein expressed by HEK293 with C-hFc labeled tag EPOR-CD131 Heterodimer Protein Human (HEK293 Fc) has molecular weight of 110-130 kDa
Medchemexpress LLC IFNAR1 Human Bioti 50ug | 50ug
IFNAR1 one of the subunit of IFN- / receptor is a type I IFN receptor IFNAR1 forms the heterodimeric receptor with IFNAR2 IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2] Upon activation by these IFNs IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events including the phosphorylation of Tyk2 and JAK1 STAT1 and STAT2[3] IFNAR1 Protein Human (Biotinylated HEK293 His-Avi) is a biotinylated recombinant human IFNAR1 (K28-K436) with C-terminal His and Avi tag which is produced in HEK293 cells
Active Motif BIX-01294
Active Motif's BIX-01294 is a selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 uM) as well as GLP histone methyltransferase (IC50 = 38 uM) leading to a decrease in histone H3 lysine 9 methylation (H3K9me2) in vitro. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells.
Cayman Chemical ANTIBODY AB-928 5mg
An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro; reduces tumor growth in an AT3-OVA syngeneic mouse model alone or in combination with doxorubicin; acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model
Cayman Chemical CefotIam hexetIlhydrochLRI 5mg
A pan-selenoprotein inhibitor and prodrug form of cefotiam; inhibits GPX1, GPX4, and TrxR1 in cell-free assays from 1-100 µM
Medchemexpress LLC 18α-Glycyrrhetinic acid | 1449-05-4 | MFCD00064897 | 470.68 | 25 MG
18α-Glycyrrhetinic acid is a diet-derived compound that acts as an inhibitor of NF-κB and an activator of proteasome. It serves as a pro-longevity and anti-aggregation factor in multicellular organisms and induces apoptosis.
- Reduces LX-2 cell numbers
- Increases percentage of LX-2 cells in phase G0/G1 and decreases in phase S
- Increases apoptosis in LX-2 cells
- Induces expression of PPAR-γ and alters certain cell cycle and apoptosis-related proteins
- Inhibits NF-κB DNA-binding activity
- Enhances life span of *C. elegans* strains
- Delays paralysis in *C. elegans*
- Reduces Aβ deposits in *C. elegans*
Medchemexpress LLC CPYPP is a DOCK2-Rac1 interaction inhibitor. | 310460-39-0 | 98.5% | 324.76 | 100 MG
CPYPP is a DOCK2-Rac1 interaction inhibitor that binds to the DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1. It also inhibits DOCK180 and DOCK5, with less significant inhibition of DOCK9. This compound has been shown to block chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, leading to reduced chemotactic response and T cell activation. In HEK293T cells, CPYPP markedly suppresses DOCK2-induced Rac activation.
- Binds to the DOCK2 DHR-2 domain
- Inhibits GEF activity of DOCK2DHR-2 for Rac1
- Inhibits DOCK180 and DOCK5
- Blocks chemokine and antigen receptor-mediated Rac activation
- Reduces chemotactic response and T cell activation
- Suppresses DOCK2-induced Rac activation
Selleck Chemical LLC Terlipressin Acetate 25mg 14636-12-5 Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Cys4-Cys9)
Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
![Medchemexpress LLC Benzeneacetamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]- | 333436-43-4 | 98.17% | 324.40 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000391646.png-250.jpg)
Medchemexpress LLC Benzeneacetamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]- | 333436-43-4 | 98.17% | 324.40 | 5 MG
This product, A3AR antagonist 5, is intended for use as laboratory chemicals and in the manufacture of substances. It is a solid that is stable under recommended storage conditions. It is for research use only and has not been fully validated for medical applications.
- Stable under recommended storage conditions
- Suitable for laboratory use
- Not a hazardous substance or mixture
Apexbio Technology LLC Prucalopride, 10mg. Cas: 179474-81-8 MFCD: MFCD09837787. 5-HT4A and 5-HT4B receptor agonist
Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. Phase 3. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC HY-13615A 5mg , EC-17 (disodium salt) CAS:910661-33-5 Purity:>98%
HY-13615A 5mg EC-17 (disodium salt) CAS: 910661-33-5 EC-17 (disodium salt) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The peak excitation and emission wavelengths of EC-17 are 470/520 nm. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.