Bioactive Small Molecules
Cayman Chemical ANTIBODY ABX-1431 50mg
An inhibitor of MAGL (IC50s = 14 and 27 nM for human and rat enzyme, respectively); selective for MAGL over ABHD6 and PLA2G7 (IC50s = 2.7 and >10 μM, respectively), as well as a panel of 33 serine hydrolases and a panel of 95 enzymes, receptors, transporters, and ion channels at 10 μM; selective for MAGL over CYP1A2, CYP2C9, CYP2C19, and CYP3A4/5 (IC50s = >50 μM); inhibits MAGL activity in mouse and rat brain ex vivo (ED50s = 1.4 and 0.5 mg/kg, respectively); decreases brain levels of 2-AG in mice and rats; reduces formalin-induced paw-licking time in rats
Medchemexpress LLC TGF-βri inhibitor 3 | 666729-57-3 | 99.2% | C21H21NO4 | 10MG
TGF-βRI inhibitor 3 is a selective small-molecule inhibitor of the transforming growth factor-β receptor I used in research to block TGF-β signaling. It is supplied as a light yellow solid with high reported purity and is intended for in vitro and preclinical assays when stored under recommended conditions.
- Selective inhibition of TGF-β receptor I signaling.
- High reported purity (≈99.2%).
- Solid, light yellow physical form for ease of handling.
- Available in multiple small-scale package sizes for research use.
- Stable under manufacturer-recommended storage conditions.
Selleck Chemical LLC Ac4ManNAz E7558-5MG
Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent Ac4ManNAz can be used to selectively modify proteins Ac4ManNAz can be used in cell labeling tracking and proteomic analysis Ac4ManNAz is a click chemistry reagent it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Cayman Chemical CholIc AcId nIlIde 5mg
A synthetic bile acid and derivative of cholic acid; inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM)
Medchemexpress LLC HY-100653A 10mg , AZD5153 (6-Hydroxy-2-naphthoic acid) CAS:1869912-40-2 Purity:>98%
HY-100653A 10mg AZD5153 (6-Hydroxy-2-naphthoic acid) CAS: 1869912-40-2 AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
STEMCELL Technologies CHIR99021, Size: 25 mg
Inhibit both GSK3β and GSK3α with CHIR99021. Together with other small molecules and growth factors, CHIR99021 maintains undifferentiated mouse ES cells (Ying et al. Nature, 2008), promotes self-renewal of human ES cells and mouse epiblast stem cells (Kim et al. Nat Commun, 2013), and allows for lineage reprogramming of fibroblasts to mature neurons (Hu et al. Cell Stem Cell, 2015; Li et al. Cell Stem Cell, 2009). This WNT activator also promotes the growth of mouse and human intestinal stem cells (Wang et al. Gastroenterology, 2013), and promotes the differentiation of human iPS cells to insulin-producing cells (Kunisada et al. Stem Cell Res, 2012) and cardiomyocytes (Lian et al. Nat Protoc, 2013). CHIR99021 is supplied as a crystalline solid with ≥95% purity; Molecular weight 465.3 g/mol; CAS Number 252917-06-9. Visit STEMCELL.com for more information and related products.
TARGETMOL CHEMICALS INC NFATC1-IN-1 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL with an IC50 of 1.57 uM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1]. purity: 99%
Cayman Chemical ANTIBODY NG-497 5mg
An ATGL inhibitor (IC50 = 1 µM); selective for ATGL over PNPLA1, PNPLA3, PNPLA4, and PNPLA5 at 100 µM; selectively inhibits the triacylglycerol hydrolase activity of human and rhesus monkey ATGL over rat, dog, and marmoset ATGL, which it inhibits by less than 20% at 50 µM, and over mouse, goat, and pig ATGL at which it is inactive at 50 µM; inhibits isoproterenol-induced fatty acid and glycerol release in human SGBS adipocytes (IC50 = 1.5 µM for both)
Selleck Chemical LLC Cpd. 37 E4750-100MG
MYC-IN-3 (Cpd 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1 27 M in PC3 cells and preventing MYC/MAX binding to DNA It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer
Cayman Chemical Lourern B 5mg
A flavonoid with diverse biological activities; inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells; inhibits phytohemagglutinin-induced IL-2 release in Jurkat T cells; reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay at 25 μg/ml; reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue; increases glucose absorption and intracellular ATP levels in Ins-1 cells
Medchemexpress LLC 2-Methyltetrahydrofuran-3-one | 3188-00-9 | MFCD00010423 | 99.7% | 100.12 | 1 ML
2-Methyltetrahydrofuran-3-one is identified as a quorum sensing inhibitor capable of preventing biofilm formation by *H. alvei*. It is also recognized as one of the volatile components found in roasted coffee. This product is intended for research use only and is not sold to patients.
- Quorum sensing inhibitor
- Inhibits biofilm formation by *H. alvei*
- One of the volatile constituents of roasted coffee
Cayman Chemical ANTIBODY IMR-1 25mg
An inhibitor of Maml1 recruitment to chromatin; binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1 to chromatin; inhibits colony formation in Notch-dependent cell lines but not Notch-independent cell lines at 15 and 45 µM; decreases the expression of Notch target genes and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model at 15 mg/kg
Cayman Chemical ANTIBODY RoquInImex 100mg
An immunomodulator with diverse biological activities; increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis at 80 mg/kg; induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic GVHD; decreases colonic MPO activity and mucosal damage in a mouse model of DSS-induced colitis at 300 mg/kg; decreases tumor weight and tumor blood flow in a VHL type 2a paraganglioma mouse xenograft model
Cayman Chemical ANTIBODY LIpoamIde 5g
An amide derivative of lipoic acid; an essential cofactor for enzymes in the citric acid cycle and enzymes involved in the catabolism of glycine and BCAAs; reduces hydrogen peroxide- or 6-OHDA-induced cytotoxicity in PC12 cells at 50 and 100 µM; reverses mitochondrial dysfunction, increases the number of midbrain dopaminergic neurons, and improves fine motor activity in a rat model of 6-OHDA-induced Parkinson’s disease at 100 mg/kg
Cayman Chemical CalcIum Ionphore I 5mg
A Ca2+-selective ionophore for biological membranes that can be used in microelectrodes for the determination of resting Ca2+-activities and of slowly changing Ca2+ levels