Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,316 – 6,330 of 60,541 results

6,316

Medchemexpress LLC Fractalkine/CX3CL1 2ug

The Fractalkine/CX3CL1 protein is a multifunctional chemokine that binds to CX3CR1 and the integrins ITGAV ITGB3 and ITGA4 ITGB1 It regulates immune responses inflammation cell adhesion and chemotaxis Fractalkine/CX3CL1 Protein Mouse (HEK293 His) is the recombinant mouse-derived Fractalkine/CX3CL1 protein expressed by HEK293 with C-6 His labeled tag

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6,317

Cayman Chemical Bendazac, Purity: ≥98%, CAS: 20187-55-7, 5 g

An NSAID; prevents denaturation of lens and serum proteins in vitro; prevents cyanate-induced opacification of the eye lens in a rat model of cataract from 10-40 mM

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6,318

Cayman Chemical AZD 3458, Purity: ≥98%, CAS: 2132961-46-5, 10 mg

A PI3Kγ inhibitor (IC50 = 0.79 nM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 7.94, >31.62, and 0.316 µM, respectively), PI3KC2α, PI3KC2γ, and PI3KC3 (IC50s = >10, 3.16, and 7.94 µM, respectively), and a panel of 395 kinases at 1 µM but does inhibit PI3KC2β (IC50 = 31.62 nM); reduces LPS-induced increases in BALF neutrophils in a rat model of acute lung inflammation at 0.1, 0.5, and 2.5 mg/kg

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6,319

Medchemexpress LLC β-spaglumic acid | 4910-46-7 | MFCD00133559 | 100.0% | 304.25 g/mol | C11H16N2O8 | 5 MG

β-Spaglumic acid (CAS 4910-46-7) is a research chemical that functions as a NAAG peptidase inhibitor for biochemical and neuropharmacological studies. It is supplied for laboratory research use only and is not intended for human or clinical applications.

High purity (99.97%) suitable for analytical and pharmacological assays.
Soluble in water, facilitating preparation of stock solutions.
Molecular formula C11H16N2O8 and molecular weight 304.25 g/mol.
Used in studies of NAAG metabolism and neuroprotection mechanisms.
Available in small, precisely measured quantities for laboratory sampling.

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6,320

Cayman Chemical Vitamin K4, Purity: ≥98%, CAS: 573-20-6, 100 g

A synthetic form of vitamin K; inhibits proliferation of PC3 cells (IC50 = 20.94 µM); induces cell cycle arrest at the S phase and mitochondrial apoptosis in PC3 cells at 20 and 40 µM; inhibits canonical and non-canonical activation of the NLRP3 inflammasome in mouse BMDMs at 5 µM; decreases the production of IL-1β and peritoneal neutrophil infiltration in a mouse model of monosodium urate-induced NLRP3-dependent peritonitis at 4 mg/kg

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6,321

Medchemexpress LLC NITD008 (7-Deaza-2'-C-acetylene-adenosine) | 1044589-82-3 | 98.0% | 1 ML

NITD008 is a potent and selective flaviviruse inhibitor, effectively targeting Dengue Virus Type 2 (DENV-2) with an EC50 of 0.64 μM. It also functions as a versatile click chemistry reagent, containing an Alkyne group suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Beyond DENV-2, NITD008 broadly inhibits various flaviviruses like West Nile, yellow fever, and Poissan virus. Demonstrating oral bioavailability and favorable pharmacokinetics, it has shown efficacy in suppressing viremia and cytokine elevation in vivo.

Potent and selective flavivirus inhibitor
Inhibits Dengue Virus Type 2 (DENV-2) (EC50 0.64 μM)
Functions as a click chemistry reagent with an Alkyne group
Orally bioavailable with favorable pharmacokinetics
Effective in vivo against flaviviruses

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6,322

AdipoGen Triptolide (10 mg)

Chemical. CAS: 38748-32-2. Formula: C20H24O6. MW: 360.4. Isolated from Tripterygium sp. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects.

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6,323

Cayman Chemical CRL-40,941, Purity: ≥98%, CAS: 90212-80-9, 1 mg

An analytical reference standard categorized as a nootropic; intended for research and forensic applications

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6,324

Cayman Chemical Vapendavir, Purity: ≥95%, CAS: 439085-51-5, 5 mg

A capsid-binding antiviral agent; inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50 = 7.3 ng/ml); inhibits replication in a panel of 21 EV71 isolates (average EC50 = 0.7 µM)

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6,325

Medchemexpress LLC (R)-aminocarnitine (emeriamine) | 98063-21-9 | MFCD27977645 | 100.0% | 160.21 g/mol | C7H16N2O2 | 100MG

(R)-Aminocarnitine (emeriamine) is a research reagent that inhibits fatty acid oxidation and is used to study metabolic disease, lipid metabolism, and related biochemical pathways. It has formula C7H16N2O2, molecular weight 160.21 g/mol, and is supplied with high reported purity for laboratory research.

Inhibits fatty acid oxidation.
Reduces hyperglycemia and ketosis in reported studies.
Used for research into metabolic disease and energy metabolism.
Reported high purity suitable for biochemical assays.
Supplied in a range of small package sizes for laboratory use.

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6,326

Cayman Chemical Lithocholic Acid 3-sulfate (sodium salt), Purity: ≥98%, CAS: 64936-81-8, 5 mg

A metabolite of lithocholic acid; water soluble and the primary form of lithocholic acid in the bile duct; forms a complex with calcium in vitro; biliary secretion increased in a rat model of streptozotocin-induced diabetes

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6,327

Cayman Chemical Eledoisin, Purity: ≥98%, CAS: 69-25-0, 1 mg

An undecapeptide tachykinin neuropeptide and NK receptor agonist; binds to NK1 (pD2 = 9.5 and 9.21 in isolated dog carotid artery and guinea pig ileum, respectively), NK2 (pD2 = 8.22 and 7.7 in isolated rabbit pulmonary artery and rat duodenum, respectively), and NK3 (pD2 = 7.11 and 7.06 in isolated rat portal vein and hamster urinary bladder, respectively); induces contraction of isolated guinea pig ileum and rabbit jejunum; induces salivation in rats; lowers arterial blood pressure in rabbits and guinea pigs in vivo

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6,328

Medchemexpress LLC PSB-KK1415 | 885896-26-4 | 99.9% | 462.93 | 25 MG

PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM. This product is for research use only and not sold to patients.

Selective agonist for human orphan G protein-coupled receptor GPR18
Potentially a promising drug target for cancer and immunity

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6,329

Cayman Chemical LDC-4297, Purity: ≥98%, CAS: 1453834-21-3, 25 mg

A CDK7 inhibitor (IC50 = 50s = >10, >10, and 1.71 μM); inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively); induces apoptosis in A549, HeLa, and HCT116 cancer cells from 10-100 nM; inhibits HCMV replication in human fibroblasts (EC50 = 24.5 nM); reduces replication of various viruses (EC50s = 0.02-1.13 μM)

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6,330

Medchemexpress LLC Heneicosane | 629-94-7 | MFCD00009346 | 296.57 | C21H44 | 5 G

Heneicosane is an analytical reference standard (C21H44, MW 296.57) used for research and analytical applications, including studies in insect chemical ecology and investigations of anti-inflammatory and antifungal activity.

Analytical standard grade for research and analytical assays.
Molecular weight 296.57 and formula C21H44.
CAS number 629-94-7 for unambiguous identification.
Available pack sizes vary by supplier; manufacturer lists up to 1 g, supplier SKU indicates 5 g (pack-size discrepancy).
Store under recommended conditions as specified in the certificate of analysis.

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Bioactive Small Molecules

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Medchemexpress LLC Fractalkine/CX3CL1 2ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC β-spaglumic acid | 4910-46-7 | MFCD00133559 | 100.0% | 304.25 g/mol | C11H16N2O8 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NITD008 (7-Deaza-2'-C-acetylene-adenosine) | 1044589-82-3 | 98.0% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (R)-aminocarnitine (emeriamine) | 98063-21-9 | MFCD27977645 | 100.0% | 160.21 g/mol | C7H16N2O2 | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PSB-KK1415 | 885896-26-4 | 99.9% | 462.93 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Heneicosane | 629-94-7 | MFCD00009346 | 296.57 | C21H44 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More