Bioactive Small Molecules
Medchemexpress LLC N-methyl-2-pyrrolidone | 872-50-4 | MFCD00003193 | 100.0% | 99.13 g/mol | C5H9NO | 1kg
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) a five-membered cyclic amide is an orally active organic polar solvent with teratogenicity and toxicity N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice N-Methylpyrrolidone is extensively used in the manufacture of adhesives paints fuels and pharmaceuticals[1][2][3][4]
Cayman Chemical (±)-Epibatidine (hydrochloride), Purity: ≥98%, CAS: 162885-01-0, 5 mg
An agonist of α4β2 subunit-containing nAChRs (Ki = 43 pM); selective for α4β2 subunit-containing nAChRs over α7 nAChRs (Ki = 230 nM); 86Rb+ flux in IMR-32 cells (EC50 = 7 nM); induces dopamine release from rat striatal slices (EC50 = 0.4 nM); induces analgesia in the hot plate test and the Straub-tail response in mice (ED50s = 0.005 and 0.02 mg/kg, respectively)
Cayman Chemical TM5441, Purity: ≥98%, CAS: 1190221-43-2, 5 mg
A PAI-1 inhibitor; decreases survival of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cancer cells (IC50s = 13.9-51.1 µM); inhibits branching of HUVECs (50 µM); disrupts tumor vasculature in mouse xenograft models (20 mg/kg per day); prevents L-NAME-induced hypertension and cardiac hypertrophy; protects against NAFLD in mice induced by high-fat diet
Cayman Chemical Itacitinib, Purity: ≥95%, CAS: 1334298-90-6, 1 mg
A JAK1 inhibitor; >20- and >200-fold selective for JAK1 over JAK2 and JAK3, respectively
Medchemexpress LLC PG-931 | 667430-81-1 | >99.8% | 1180.40 | 1 MG
PG-931 is an analog of SHU 9119 and acts as a potent agonist for the melanocortin 4 (MC4) receptor. It demonstrates higher selectivity for the hMC4R compared to the hMC3R or the hMC5R. In vivo, PG-931 can reverse hemorrhagic shock and prevent multiple organ damage.
- Potent agonist for melanocortin 4 (MC4) receptor
- Higher selectivity for hMC4R compared to hMC3R or hMC5R
- Can reverse hemorrhagic shock in vivo
- Can prevent multiple organ damage in vivo
Medchemexpress LLC Semaphorin-3A/SEMA3A 100ug
Recombinant human Semaphorin-3A (SEMA3A) expressed in HEK293 cells and supplied as a lyophilized, purified protein with N-terminal 6xHis and Flag tags. The protein is provided in multiple size options for research use in studies of axon guidance, neuronal development, and SEMA3A signaling. Predicted molecular mass is ~61.3 kDa (apparent 70-75 kDa by SDS-PAGE due to glycosylation). Purity >95% and endotoxin <1 EU/μg; refer to the lot-specific COA for exact buffer and handling information.
- High purity for consistent experimental results.
- Low endotoxin suitable for cell-based assays.
- N-terminal affinity tags facilitate detection and purification.
- Multiple size options to match experimental scale.
- Lyophilized format for extended shelf life and easy storage.
- HEK293 expression preserves mammalian post-translational modifications.
Cayman Chemical CAY10735, Purity: ≥90%, CAS: 2251753-58-7, 1 mg
An anticancer compound; inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM); inhibits migration of and EMT in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner; reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of ROS in these cells in a concentration-dependent manner; reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model at 5 mg/kg
Medchemexpress LLC Bax inhibitor peptide V5 | 579492-81-2 | 99.9% | 586.79 | 10 MG
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, primarily used for cancer treatment. This peptide reduces cell death in STF-cMyc cells and functions by upregulating anti-apoptotic proteins such as Bcl-2 and XIAP, while concurrently downregulating apoptosis-inducing proteins like Bax, Bad, and nuclear factor-κB-p65.
- Bax-mediated apoptosis inhibitor
- Reduces cell death in STF-cMyc cells
- Upregulates anti-apoptotic proteins Bcl-2 and XIAP
- Downregulates apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65
- Improves islet function and enhances islet graft function in mouse models
Cayman Chemical LATS-IN-1, Purity: ≥98%, CAS: 1424635-83-5, 1 mg
An inhibitor of LATS1 and LATS2 (IC50s = 2 nM for both); inhibits phosphorylation of YAP1 in serum-starved HEK293A cells (EC50 = 510 nM); increases the proliferation of Müller glial cells and isolated mouse cardiomyocytes at 10 µM
Medchemexpress LLC Human IgG1 L234A L2 50mg | 50mg
Human IgG1 (L234AL235A) kappa Isotype Control a human monoclonal antibody is an isotype control for human IgG1 antibody
Medchemexpress LLC Janelia Fluor 646, Tetrazine | 2042192-00-5 | 90.17% | 665.82 | 200 UG
Janelia Fluor 646, Tetrazine is a red fluorescent dye containing a tetrazine group. It is utilized in cellular imaging as a click chemistry reagent, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain TCO groups.
- Red fluorescent dye
- Contains a tetrazine group
- Suitable for cellular imaging
- Click chemistry reagent
- Undergoes inverse electron demand Diels-Alder reaction (iEDDA)
- Photostable
- Membrane-permeable
- High extinction coefficient
Medchemexpress LLC HY-136979 5mg Medchemexpress, RBN012759 CAS:2360851-29-0 Purity:>98%
Medchemexpress, HY-136979 5mg RBN012759 CAS:2360851-29-0 RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Coh-SR4 | 73439-19-7 | 99.5% | 350.03 g/mol | C13H8Cl4N2O | 100MG
COH-SR4 is a research-grade small molecule AMPK activator with demonstrated antiproliferative effects in leukemia, melanoma, breast, and lung cancer cell lines. It also inhibits adipocyte differentiation via AMPK activation and is supplied as a solid with documented purity and storage recommendations for laboratory research use only.
- Activates AMP-activated protein kinase (AMPK) in cellular assays.
- Demonstrates antiproliferative activity across multiple cancer cell lines.
- Inhibits adipocyte differentiation, supporting metabolic research.
- Provided as a solid with documented high purity and storage guidelines.
- Available in multiple sizes to support varied experimental needs.
- Intended for laboratory research use only; not for human or veterinary use.
Medchemexpress LLC Denfivontinib hydrochloride | 1457983-28-6 | MFCD28167815 | 98.0% | 521.41 g/mol | C25H25BrN6O2 | 10MM 1ML
Denfivontinib hydrochloride is a potent, ATP-competitive FLT3 inhibitor used in preclinical research on acute myeloid leukemia and agent resistance. The product is supplied as a 10 mM solution in DMSO (1 mL) and is intended for research use only. Chemical identifiers include CAS 1457983-28-6, formula C25H25BrN6O2, and molecular weight 521.41 g/mol.
- Potent ATP-competitive FLT3 inhibitor.
- Supplied as a 10 mM solution in DMSO (1 mL).
- Suitable for preclinical AML and resistance research.
- High purity (98.0%).
- Provided as the hydrochloride salt form.
Active Motif Sirtinol
Active Motif's Sirtinol is a selective sirtuin inhibitor that does not effect HDAC1 (IC50 = 131 M, 38 M and 68 M for SIRT1, SIRT2 and Sir2P respectively). It induces apoptotic and autophagic cell death in MCF-7 human breast cancer cell lines and suppresses survivin expression, which correlates with decreased viability in HT29 colon cancer cells. Sirtinol displays pro-inflammatory effects in adipocytes.
