Bioactive Small Molecules
Medchemexpress LLC Heclin 10mM | 890605-54-6 | 98.2% | 283.32 | 10 MG
Heclin is a HECT E3 ubiquitin ligases inhibitor. It inhibits Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively, and can be used for the research of gastric cancer.
- Functions as a HECT E3 ubiquitin ligases inhibitor.
- Inhibits Smurf2, Nedd4, and WWP1.
- Useful for gastric cancer research.
- Inhibits cell viability and IGF1 signaling in BGC803 and MKN45 cell lines.
- Ameliorates epinecidin-1-mediated MyD88 degradation in Raw264.7 cells.
Cayman Chemical ANTIBODY PK68 5mg
A RIPK1 inhibitor (IC50 = 90 nM); selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM; inhibits necroptosis induced by TNF-α, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM); reduces the number of lung metastases in a B16/F10 murine melanoma model at 5 mg/kg; increases survival and prevents decreases in body temperature and increases in serum Il-1β levels in a mouse model of Tnf-α-induced SIRS at 1 mg/kg
Cayman Chemical ANTIBODY TDI-10229 25mg
A soluble adenylyl cyclase inhibitor (IC50 = 0.2 µM for the human enzyme in a cell-free assay); selective for sAC over AC1-3, -5, -8, and -9 at 10 µM; inhibits cAMP accumulation induced by IBMX in rodent sAC-expressing HEK293 cells (IC50 = 0.1 µM); inhibits capacitation-induced cAMP accumulation and PKA activation in isolated mouse and human sperm at 5 µM; prevents the acrosome reaction and fertilization of mouse sperm with mouse oocytes in vitro at 5 and 50 µM
Medchemexpress LLC 3,5-diiodothyropropionic acid | 1158-10-7 | MFCD00045945 | 99.2% | 510.06 g/mol | C15H12I2O4 | 10MM 1ML
3,5-diiodothyropropionic acid is a thyroid hormone analog used to probe thyroid hormone receptor activity and metabolic effects in cellular and biochemical research. The compound is characterized by CAS 1158-10-7, molecular formula C15H12I2O4, and molecular weight 510.06 g/mol. It is supplied as a 10 mM solution (1 mL) and is also available in solid quantities for analytical or preparative use.
- Useful for receptor binding and metabolic pathway studies.
- Supplied as a ready-to-use 10 mM solution for in vitro assays.
- Available in solid doses for storage or bulk use.
- High purity suitable for analytical and research applications.
- Characterized by CAS 1158-10-7 and established molecular data.
Cayman Chemical StercobIlInhydrochlorIde 5mg
A fecal pigment and metabolite of bilirubin; induces DNA damage in a comet assay in HepG2 cells at 0.5-17 µM; induces activation of NF-κB in a reporter assay and increases the expression of the genes encoding TNF-α, IL-1β, IL-6, iNOS, and COX-2 in RAW 264.7 macrophages at 20 and 30 µM; fecal and plasma levels are increased in ob/ob mice
Medchemexpress LLC Sematilide hydrochloride | 101526-62-9 | 99.3% | 349.88 g/mol | C14H24ClN3O3S | 1 ML
Sematilide hydrochloride is a research-grade IKr (delayed rectifier potassium) channel blocker used in electrophysiology and pharmacology studies. The compound is supplied at high purity with molecular data and solubility guidance to support preparation of stock solutions and experimental use.
- High purity suitable for research applications.
- Molecular weight and formula provided for calculation and reporting.
- Solubility and stock-solution guidance available for assay preparation.
- Supplied in forms suitable for aliquoting and storage.
- Intended for in vitro electrophysiology and pharmacology studies.
Cayman Chemical ANTIBODY DM1-SMe 1mg
A mertansine analog; has in vitro activity against the PPTP panel of cancer cell lines (IC50s = 0.002 to >3 nM)
Apexbio Technology LLC Rizatriptan Benzoate 145202-66-0 50mg
Rizatriptan Benzoate (CAS 145202-66-0) is a synthetic small molecule structurally related to tryptamine that acts as a selective agonist at serotonin 5-HT1D receptors By targeting these G protein-coupled receptors Rizatriptan Benzoate modulates the release of vasoactive neuropeptides and inhibits neurogenic inflammation and vasodilation associated with cranial blood vessels This pharmacological profile has made it a valuable tool for investigating serotonergic signaling pathways receptor pharmacodynamics and migraine pathophysiology in preclinical research settings
Cayman Chemical VerdIperstat 5mg
An irreversible inhibitor of MPO (IC50 = 630 nM); selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all); reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy at 180 µmol/kg, p.o.
Medchemexpress LLC EGFR Human sf9 Hi 5ug
EGFR is a transmembrane glycoprotein EGFR binds to ligands triggering receptor dimerization inducing intracellular TK domain autophosphorylation activating downstream Ras/MAPK PI3K/Akt and other signaling pathways and regulating cell proliferation survival migration and angiogenesis EGFR Protein Human (sf9 His-GST) is a recombinant EGFR protein expressed by Sf9 insect cells with N-His N-GST tags
AdipoGen Lycorine hydrochloride (20 mg)
Chemical. CAS: 2188-68-3. Formula: C16H17NO4 . HCl. MW: 323.77. Lycorine is an active alkaloid abundant in Amaryllidaceae with a wide range of biological properties, including antifungal, antiparasitic, antiviral, anti-inflammatory and anticancer activity. It is a protein synthesis by preventing amino acid incorporation into proteins, potentially through the inhibition of peptidyltransferases. Lycorine induces cell cycle arrest and cell death in Trichomonas. As anticancer agent on a molecular basis it induces G0/G1 phase cell cycle arrest and apoptosis, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, inhibits the Wnt/beta-catenin pathway, activates ROCK1and inhibits JAK/STAT pathways. Lycorine exhibits antiviral activities against enterovirus, flaviviruses, Zika virus, HIV-1, SARS-CoV, SARS-CoV-2 and hepatitis C virus, most probably by suppressing viral replication.
Cayman Chemical ANTIBODY AZD 8797 1mg
A CX3CR1 antagonist (Ki = 3.9 nM); selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM); inhibits CX3CL1-induced [35S]GTPγS accumulation in CHO cell membranes expressing human CX3CR1 from 0.1-10 µM; inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM); reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced EAE at 39 and 78 µmol/kg per day
Cayman Chemical ANTIBODY TA-01 5mg
An inducer of cardiomyocyte differentiation; increases expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreases expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells at <5 μM; inhibits CK1ε and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members
Medchemexpress LLC HY-136360 5mg Medchemexpress, MI-3454 CAS:2134169-43-8 Purity:>98%
Medchemexpress, HY-136360 5mg MI-3454 CAS:2134169-43-8 MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen AST-487 (1 mg)
Chemical. CAS: 630124-46-8. Formula: C26H30F3N7O2. MW: 529.6. AST487 is an inhibitor of RET (IC50 = 0.88µM), FLT3 (Ki = 0.52µM), KDR (IC50 = 0.17µM), c-Abl (IC50 = 0.02µM) and c-Kit (IC50 = 0.5µM). AST-487 has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. AST-487, which selectively targets mutant FLT3 protein kinase activity, is also shown to override PKC412 resistance in vitro, and has significant antileukemic activity in an in vivo model of FLT3-ITD(+) leukemia. The combination of AST-487 with standard chemotherapeutic agents leads to enhanced inhibition of proliferation of mutant FLT3-expressing cells.