Bioactive Small Molecules
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Filtered Search Results
Medchemexpress LLC UK4b | 2171000-87-4 | 96.17% | 404.89 | 5 MG
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UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. It possesses anti-inflammatory and analgesic effects. UK4b has also been shown to block the growth of abdominal aortic aneurysms in mice.
- Highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
- Possesses anti-inflammatory effects.
- Possesses analgesic effects.
- Can block the growth of abdominal aortic aneurysms in mice.
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Cayman Chemical ANTIBODY 1-A-N 10mg
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An ionizable cationic lipid; has been used in the generation of LNPs for siRNA delivery in vivo; LNPs containing 1-A-N and encapsulating siRNA targeting the gene encoding CD45 reduce its gene expression in splenic T cells in mice
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MSC
5000520413 368-876 6 TO 7 INCH FIXED ANVI
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Abcam Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor, 5MG
MW 202.17 Da, Purity >99%. Cell-permeable and competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 μM). Effects platelet-derived growth factor (PDGF) and insulin receptor tyrosine kinases. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
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Cayman Chemical LorglumIdesodIum salt 5mg
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A nonpeptidic antagonist of CCK1 (IC50 = 50 nM) that is 60-fold less effective at CCK2 (IC50 = 3 µM); blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion; commonly used to study the roles of CCK1 in tissues and in animals
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Cayman Chemical ANTIBODY HCV-IN-31 25mg
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An antiviral nucleoside; inhibits HCV replication in an HCV replicon assay (EC50 = 15.7 µM)
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Medchemexpress LLC 1H-Pyrazolo[3,4-d]pyrimidine-3-carboxamide, 4-amino-N-[4-[2-(dimethylamino)-2-oxoethyl]] | 2088323-16-2 | 99.7% | 504.58 | 25 MG
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TAS0728 is a potent, selective, orally active, irreversible, and covalent-binding HER2 inhibitor with an IC50 of 13 nM. It also demonstrates inhibitory activities against BMX, HER4, BLK, EGFR, JAK3, SLK, and LOK with IC50s of 4.9, 8.5, 31, 65, 33, 25, and 86 nM, respectively. TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors.
- Inhibits proliferation of five HER2-amplified cell lines with GI50 values ranging from 1.6 to 6.9 nM.
- Shows sustained inhibition of HER2, HER3, AKT, and ERK phosphorylation in SK-BR-3 cells.
- Provides sustained and targeted inhibition of HER2, HER3, AKT, and ERK phosphorylation in vivo.
- Causes tumor regression and exhibits low toxicity in animal models.
- Demonstrated sustained target inhibition and was well tolerated in male nude mice.
- Significant tumor regression observed at higher doses in xenograft models.
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American Research Products Inc AMERICAN RESEARCH PRODUCTS INC
5000610165 RAT SIRT5 ELISA KIT
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Cayman Chemical ANTIBODY UNBS5162 5mg
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An antagonist of CXCL chemokine expression; demonstrates antiangiogenic properties both in vitro and in vivo in prostate cancer research models
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Medchemexpress LLC 2-propenoic acid, homopolymer | 9003-01-4 | MFCD00084394 | 450,000 (average) | (C3H4O2)X | 10 G
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Poly(acrylic acid) (average Mw 450,000) is a high-molecular-weight anionic polymer used in research and formulation applications where surface stabilization, thickening, or corrosion mitigation is required. It is supplied as a white to off-white solid and should be stored sealed, away from moisture.
- High average molecular weight for effective viscosity and film formation.
- Anionic polyelectrolyte useful for stabilizing colloids and suspensions.
- Compatible with aqueous systems and common laboratory solvents.
- Suitable for corrosion inhibition, coatings, and drug delivery research.
- Solid form simplifies handling and preparation of small laboratory quantities.
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Cayman Chemical ANTIBODY TAS 120 5mg
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An orally bioavailable inhibitor of FGFRs that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations; blocks the proliferation of human cancer cell lines with FGFR gene abnormalities
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American Research Products Inc AMERICAN RESEARCH PRODUCTS INC
5000615704 MIF ELISA KIT
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Cayman Chemical ANTIBODY Ramelteon 10mg
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A melatonin receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively); selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 μM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors, ion channels, transporters, and enzymes when used at a concentration of 10 μM; stimulates cAMP production in CHO cells expressing human MT1 and MT2 receptors (IC50s = 21.2 and 53.4 pM, respectively); shortens latency to sleep onset and increases duration of sleep in free moving crab-eating macaques at 0.03 and 0.3 mg/kg; accelerates reentrainment of circadian rhythm in rats at 0.1 and 1 mg/kg
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Cayman Chemical ANTIBODY PCTR2 50ug
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A specialized pro-resolving mediator; found in resolving mouse exudate and both M1 and M2 human macrophages
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Selleck Chemical LLC PDD00017273 | 1945950-21-9 | MFCD30536372 | 5 mg
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PDD00017273 | Purity: 99% | Mol Wt: 514.62 | 1945950-21-9 | MFCD30536372 | 5 mg *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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