Bioactive Small Molecules
Cayman Chemical ANTIBODY A-485 10mg
A p300/CBP inhibitor (IC50 = 60 nM); decreases H3K27Ac levels in PC3 cells; reduces proliferation of various tumor cell lines; inhibits expression of PSA and H3K27Ac occupancy at the PSA enhancer in LNCaP-FGC cells; reduces tumor volume in a LuCaP-77 mouse xenograft model of castration-resistant prostate cancer at 100 mg twice per day for 21 days
Cayman Chemical GnglIosIde GD1bbovInso 5mg
A mixture of ganglioside GD1b molecular species isolated from bovine brain with primarily C18:0 fatty acyl chain lengths; a component of plasma membranes; packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events; the concentration of ganglioside GD1b in human brain increases with age
Cayman Chemical ANTIBODY-mT5-14 5mg
A derivative of remdesivir with antiviral activity; increases the viability of Vero E6 cells infected with SARS-CoV-2 (EC50 = 0.4 µM), as well as Vero E6 cells infected with the Alpha, Beta, Gamma, or Delta SARS-CoV-2 variants (EC50s = 2.5, 15.9, 1.7, and 5.6 µM, respectively); exhibits increased plasma and lung concentrations compared with remdesivir in hamsters at 10 mg/kg
Selleck Chemical LLC Serabelisib (TAK-117) 5mg 1268454-23-4 INK-1117, MLN-1117
Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3K? isoform inhibitor (IC50 of 21 nmol/L against PI3K?) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3K?/?/?) and mTOR, and a high degree of selectivity against many other kinase. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ANTIBODY Tolvaptn 1mg
An analytical reference standard categorized as a diuretic; intended for use in analytical forensic applications
STEMCELL Technologies GDC-0941, Size: 10 mg
GDC-0941 is an inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K). It inhibits class I catalytic subunits of PI3K p110α, β, δ, and γ with IC₅₀ values of 3, 33, 3, and 75 nM, respectively, by binding near the ATP binding pocket (Folkes et al.; Berndt et al.). It shows selectivity against class II, III, and IV PI3K isoforms as well, but with lower efficacy; for example, it inhibits phosphatidylinositol-4-phosphate 3-kinase C2 domain subunit β (C2β, Class II) and mammalian target of rapamycin (mTOR, Class IV) in the high nanomolar range and most others in the micromolar range (Folkes et al.).CANCER RESEARCH· Inhibits proliferation of multiple cancer cell lines, such as U87MG (glioblastoma), PC3 (prostate) and MDA-MB-361 (breast) lines, in vitro and in mouse xenograft models (Folkes et al.; Raynaud et al.; O’Brien et al.). · Induces apoptosis and inhibits xenograft tumor growth in combination with a MAP/ERK kinase (MEK) inhibitor GDC-0973 (Hoeflich et al.).
Cayman Chemical ForsythosIde B 5mg
A phenylpropanoid glycoside with diverse biological activities; scavenges PTIO, ABTS, O2-, and DPPH radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively); reduces hydrogen peroxide-induced cytotoxicity in bmMSCs from 10-100 μg/ml; inhibits 2-aminoethoxydiphenyl borate-induced activation of TRPV3 (IC50 = 6.7 μM in HEK293 cells expressing the human receptor); reduces carvacrol-induced scratching behavior in mice; reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and TREM-1 and increases survival in a rat model of cecal ligation and puncture-induced sepsis at 40 mg/kg; reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion
Medchemexpress LLC BMS 182874 | 153042-42-3 | 345.42 | C17H19N3O3S | 1 ML
BMS 182874 is an orally active, highly selective endothelin A (ETA) receptor antagonist used in cardiovascular and GPCR research. Supplied as a 10 mM solution (1 mL) for laboratory research use only. Reported potency: ETA IC50 0.15 μM and Ki 0.055 μM. Molecular formula C17H19N3O3S; molecular weight 345.42. Store protected from light; in solvent store -80°C for up to 6 months.
- Provided as 10 mM solution in DMSO, 1 mL.
- Selective ETA receptor antagonist with ETA IC50 0.15 μM and Ki 0.055 μM.
- Validated in vsm-A10 cell assays for binding and Ca2+ antagonism.
- High solubility in DMSO; ultrasonic treatment may be required.
- Intended for laboratory research use only; not for human or veterinary use.
Medchemexpress LLC 1,4-anthraquinone | 635-12-1 | MFCD00013724 | 95.0% | 208.21 g/mol | C14H8O2 | 1 ML
1,4-anthraquinone is a small-molecule quinone used in biochemical and pharmacological research. Supplied as a 10 mM solution in DMSO, this product is intended for laboratory research applications and assay use.
- Used in studies of nucleoside transport inhibition.
- Inhibits macromolecule synthesis.
- Induces DNA fragmentation in cellular assays.
- Purity approximately 95.0%.
- Molecular formula C14H8O2, molecular weight 208.21 g/mol.
- Provided as a 10 mM solution in DMSO, 1 mL volume.
Cayman Chemical ANTIBODY BelzutIfn 10mg
A HIF-2α inhibitor; inhibits HIF-2α heterodimerization with the ARNT PAS-B domain in a cell-free assay (Ki = 23 nM), activation of HIF-2α in a reporter assay using 786-O renal cell carcinoma cells (IC50 = 17 nM), and secretion of VEGF-A from 786-O cells (EC50 = 17 nM); induces tumor regression in a 786-O mouse xenograft model from 0.3-3 mg/kg; reduces hematocrit levels and right ventricular pressure in mice expressing VHLR200W in a model of Chuvash polycythemia at 0.1 mg/g
Medchemexpress LLC NOD2 antagonist 1 | 2411441-54-6 | 99.6% | 474.57 | 5 MG
NOD2 antagonist 1 is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. It inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and also inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs.
- Potent and selective NOD2 antagonist
- Inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells
- Inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs
- Molecular formula: C26H26N4O3S
- Molecular weight: 474.57
Medchemexpress LLC GNE-477 | 1032754-81-6 | 98.8% | 504.63 | 50 MG
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. It is intended for research use only. In vitro, GNE-477 (Compound 8) shows improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM. In vivo, GNE-477 exhibits tumor growth stasis in a PC3 tumor growth inhibition study.
- Potent and efficacious dual PI3K/mTOR inhibitor
- Improved potency in cell proliferation assays
- Exhibits tumor growth stasis in studies
- Generally well tolerated
Cayman Chemical ANTIBODY BerteroIn 10mg
A sulforaphane analog found in cruciferous vegetables that demonstrates potent anti-inflammatory effects; doubles the phase II enzyme quinone reductase activity in mouse hepatoma cells at 1.7 µM; inhibits degradation of IκBα, NF-κB p65 translocation to the nucleus, IRAK degradation, and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt in LPS-stimulated RAW 264.7 macrophages
Cayman Chemical ANTIBODY YSK05 25mg
An ionizable cationic amino lipid (apparent pKa = ~6.5); has been used in combination with other lipids in the formation of liposomes and LNPs; administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates NK cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis; intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma
Medchemexpress LLC JNJ-38877618 | 943540-74-7 | 98.8% | 374.35 | 50 MG
JNJ-38877618 | 943540-74-7 | 98.8% | 374.35 | 50 MG