Bioactive Small Molecules
Cayman Chemical ANTIBODY HX 1171 100mg
An antioxidant; inhibits lipid peroxidation by 98 and 40% when used at concentrations of 10 and 1 µM, respectively, in rat liver microsomes; activates NRF2 by enhancing its nuclear translocation and transcriptional activity, increasing the expression of the antioxidant-related enzymes NQO1 and HMOX1 in A549 human lung epithelial cells; reduces fibrosis and the level of fibrotic markers in liver and primary hepatocytes, respectively, in a rat model of liver cirrhosis; decreases the incidence of hepatocellular adenomas and hemangiosarcomas in a rat model, but increases the incidence of forestomach carcinoma
AdipoGen Resorufin-isobutyrate
Chemical. CAS 251292-24-7. Formula C17H15NO5. MW 313.3. Synthetic. Cell permeable resorufin derivative used as a fluorogenic indicator for cell viability. Resorufin was selected as the fluorophore because it fluoresces at a longer wavelength and is amenable to modification at the hydroxyl group which is essential for its fluorescence. Incubation with esterase at pH 8.0 results in a 80-90 nm shift of emission max. Ex/Em 500/~593nm in 0.1 M Tris pH 8.0 after cleavage by esterase. This cell viability indicator is 2 times more sensitive than calcein-AM.
Medchemexpress LLC GNE-0946 | 1677667-24-1 | 98.1% | 460.79 | 25 MG
GNE-0946 is described as a potent and selective RORγ (RORc) agonist with an EC50 value of 4 nM for HEK-293 cells. It is intended for research use only and not for sale to patients.
- Potent and selective RORγ (RORc) agonist.
- EC50 value of 4 nM for HEK-293 cell.
- Exhibits inverse agonist activity at GAL4-fused human RORc, RORa, and RORb in HEK293T cells.
- Shows antiinflammatory activity in human PBMC, inhibiting IL-17 production.
- Available in solid and solution forms.
Medchemexpress LLC JNJ-46778212 | 1363281-27-9 | 99.6% | 352.36 | 1 ML
JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. This compound demonstrates excellent CNS penetration in oral brain/plasma studies and enhances NMDAR function. It restores long-term potentiation in hippocampal slices and reverses deficits in neuroplasticity signaling pathways, leading to improved contextual fear memory.
- Mglu5 positive allosteric modulator
- Excellent CNS penetration
- Enhances NMDAR function
- Restores long-term potentiation
- Reverses deficits in neuroplasticity signaling pathways
- Improves contextual fear memory
Medchemexpress LLC 3,5-dichloro-4-hydroxybenzonitrile | 1891-95-8 | MFCD00002177 | 188.01 g/mol | C7H3Cl2NO | 500 MG
Chloroxynil is a small-molecule research reagent (CAS 1891-95-8) used for analytical and biological studies. It has formula C7H3Cl2NO and a molecular weight of 188.01 g/mol. Solubility is reported as ≥ 5 mg/mL (26.59 mM) in certain solvents.
- Small-molecule research reagent for analytical use.
- CAS 1891-95-8; molecular formula C7H3Cl2NO.
- Molecular weight 188.01 g/mol.
- Reported solubility ≥ 5 mg/mL (26.59 mM) in recommended solvents.
- Pack-size availability varies by distributor; confirm specific package quantity before ordering.
Cayman Chemical DalfoprIstInmesylate 5mg
A streptogramin antibiotic that is usually combined with another streptogramin antibiotic, quinupristin, to synergistically kill Gram-positive bacteria
Cayman Chemical GermIcIdIn A 5mg
An autoregulative inhibitor of spore germination in the genus Streptomyces at concentrations as low as 200 pM; also inhibits the porcine Na+/K+-activated ATPase (ID50 = 100 µM)
Cayman Chemical ANTIBODY MEGA-9 500mg
A nonionic detergent that can be used to solubilize membrane proteins; CMC = 20 mM under no-salt conditions; CMCs = 2-17.1 mM under high and low salt conditions for a variety of salts; has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes
Medchemexpress LLC RIP2 kinase inhibitor 2 | 1581270-11-2 | 99.7% | 432.54 | 25 MG
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. It is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, IKKα/β/γ) involved in NF-κB and mitogen-activated protein kinase activation. This product is for research use only and is not sold to patients.
- Target: RIP2 kinase
- Mechanism: Inhibits RIP2 kinase
- Source: Extracted from patent WO/2014043437 A1
- Molecular weight: 432.54
- Formula: C21H28N4O4S
- Cas no.: 1581270-11-2
- Appearance: Solid
- Color: Light yellow to yellow
Sigma Aldrich Fine Chemicals Biosciences Herbimycin A from Streptomyces hygroscopicus >=95% (HPLC), powder | 70563-58-5 | MFCD00151702 | 0.1MG
Herbimycin A from Streptomyces hygroscopicus >=95% (HPLC), powder | Purity: >=95% (HPLC) | Mol Wt: 574.66 | 70563-58-5 | MFCD00151702 | 0.1MG
Medchemexpress LLC HY-114181 10mg Medchemexpress, IRAK4-IN-4 CAS:1850276-58-2 Purity:>98%
Medchemexpress, HY-114181 10mg IRAK4-IN-4 CAS:1850276-58-2 IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY IsonIazId 100g
An antibiotic that acts as a prodrug that is converted to isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis; effective against several species of Mycobacterium, including M. tuberculosis
Cayman Chemical ANTIBODY Dp44mT 10mg
An iron chelator with antiproliferative effects; inhibits in vitro proliferation of SK-N-MC neuroepithelioma, SK-Mel-28 melanoma, and MCF-7 breast cancer cells (IC50s = 30, 60, and 60 nM, respectively); increases mobilization of 59Fe from SK-N-MC cells and M109 mouse lung carcinoma cells (25 and 1 µM, respectively); enhances cytotoxicity in several multidrug resistant human cancer cell lines following transport to lysosomes by P-glycoprotein; inhibits M109 tumor growth in mice, reducing tumor weight to 47% of control values (0.4 mg/kg); reduces tumor size and weight in an oral squamous cell carcinoma mouse xenograft model (0.5 mg/kg)
Cayman Chemical ANTIBODY LCS-1 10mg
An inhibitor of SOD1 (IC50 = 1.07 µM); inhibits the proliferation of NCI H358 cells, an effect that can be decreased by overexpression of SOD1 (IC50 = 0.8 and 3.5 µM, respectively)
Apexbio Technology LLC GNE-317 1394076-92-6 100mg
GNE-317 (CAS 1394076-92-6) is a potent small-molecule inhibitor targeting phosphatidylinositol 3-kinase (PI3K) a family of enzymes crucially involved in cellular proliferation survival differentiation migration and intracellular trafficking processes In experimental studies using GL261 U87 GS2 and GBM10 glioblastoma tumor models GNE-317 effectively crosses the blood-brain barrier resulting in significant reductions of phosphorylated Akt 4EBP1 and S6 kinase downstream biomarkers indicative of PI3K/mTOR pathway inhibition Consequently GNE-317 serves as a valuable research tool for studying PI3K-mediated signaling in brain tumor models