Bioactive Small Molecules
Medchemexpress LLC TFRC Cynomolgus HE 20ug | 20ug
TFRC is a key protein in cellular iron uptake coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes where endosomal acidification triggers iron release TFRC actively regulates T and B cell proliferation through iron uptake TFRC Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived TFRC protein expressed by HEK293 with N-His labeled tag
![Medchemexpress LLC (R)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride | 125572-92-1 | MFCD14525467 | 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000266320.png-250.jpg)
Medchemexpress LLC (R)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride | 125572-92-1 | MFCD14525467 | 10mg
(R)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5 6 7 8-tetrahydronaphthalen-1-ol hydrochloride is a drug intermediate for synthesis of various active compounds
Cayman Chemical ANTIBODY RheIn 100mg
An anthraquinone derivative; induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells at 40 and 100 µM, respectively; inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions at 100 and 200 µM; reduces controlled cortical impact-induced decreases in catalase and SOD activity and MDA, glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury at 12 mg/kg; reduces cerulein-induced increases in serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis at 50 mg/kg per day
Selleck Chemical LLC Sulfo-SMCC sodium S0566-50MG
Sulfo-SMCC sodium is a hetero-bifunctional noncleavable ADC crosslinker which consists of N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups
Cayman Chemical ANTIBODY PRN-1371 10mg
An irreversible pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively); selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit CSF1R activity by >90% at 1 µM; inhibits proliferation in a panel of ten cancer cell lines containing various FGFR mutants (IC50s = 2-231 nM) and induces apoptosis in SNU-16 gastric and RT4 bladder cancer cells (EC50s = 15.9 and 11.8 nM, respectively); reduces tumor growth in an SNU-16 mouse xenograft model and a PDX mouse model of liver cancer at 15 mg/kg twice per day
Cayman Chemical C17 SphngomyelInd18 117 0 5mg
A synthetic derivative of sphingomyelin; has been used as an internal standard for the quantification of sphingomyelin
Medchemexpress LLC HY-131278 1mg Medchemexpress, Olmesartan methyl ester CAS:1347262-29-6 Purity:>98%
Medchemexpress, HY-131278 1mg Olmesartan methyl ester CAS:1347262-29-6 Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Urotensin II (114-124), human (TFA) | 251293-28-4 | 99.8% | 1502.59 | 10 MG
Urotensin II (114-124), human, is an 11-amino acid residue peptide that acts as a potent vasoconstrictor and agonist for the orphan receptor GPR14. It is intended for research use only.
- 11-amino acid residue peptide.
- Potent vasoconstrictor.
- Agonist for the orphan receptor GPR14.
- Binds to recombinant human GPR14 with high affinity, functionally coupled to calcium mobilization.
- Induces concentration-dependent increases in intracellular calcium in HEK-293 cells expressing human GPR14 (EC50=0:62±0.17 nM).
- Markedly increases total peripheral resistance in anesthetized non-human primates, associated with cardiac contractile dysfunction.
Selleck Chemical LLC Box5 P1216-1G
Box5 a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu) acts as an Wnt5a antagonist inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2 ) signaling
Medchemexpress LLC Glucosyringic acid | 33228-65-8 | 5 MG
Glucosyringic acid is a compound isolated from *Saxifraga Montana H.*. It is intended for research use only and is not sold to patients.
- Purity: 99.62%
- Molecular weight: 360.31
- Formula: C15H20O10
- Appearance: Solid
- Color: White to off-white
- Initial source: Plants (Saxifragaceae, *Saxifraga sinomontana J. T. Pan & Gornall*)
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years; in solvent at -80°C for 6 months, -20°C for 1 month
Sigma Aldrich Fine Chemicals Biosciences Netilmicin sulfate salt | 56391-57-2 | MFCD01311715 | 5MG
Netilmicin sulfate salt | Mol Wt: 720.78 | 56391-57-2 | MFCD01311715 | 5MG
Selleck Chemical LLC Rhubarb Extract E3123-5MG
Rhubarb Extract is obtained from Rheum palmatum L /Rheum officinale of which phytochemicals could promote some bacterial genders involved in gut barrier function therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption
Selleck Chemical LLC OICR-8268 E5839-5MG
OICR-8268 is a potent reversible and in-cell active DCAF1 ligand It significantly binds to DCAF1 WDR domain with an Kd value of 38 nM It serves as a promising starting point for developing chemical handles for DCAF1-based PROTACs targeting selective protein degradation as well as cancer therapeutics