Bioactive Small Molecules
Medchemexpress LLC Tetrahydrothiophen-3-one | 1003-04-9 | 99.7% | 102.15 | 1 ML
Tetrahydrothiophen-3-one is an endogenous metabolite and a pharmaceutical intermediate used to synthesize thiazole compounds. It is found in natural food and is considered safe. This high-purity liquid is ideal for various research applications.
- Endogenous metabolite and pharmaceutical intermediate.
- Used to synthesize thiazole compounds.
- Exists in natural food and has good safety.
- High purity of 99.72%.
- Molecular weight of 102.15.
- Liquid appearance, colorless to light yellow.
- Soluble in DMSO for in vitro applications.
- Multiple protocols for in vivo solubility.
- Recommended storage at 4°C, protected from light.
Medchemexpress LLC Isoxazole | 288-14-2 | 100.0% | 69.06 | 1 ML
Isoxazole is a five-membered heterocycle drug scaffold that has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Its derivatives show broad biological activities, including antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects.
- Broad biological activities: Isoxazole and its derivatives exhibit a wide range of biological activities.
- BET bromodomain inhibitor: It has been used as a BET bromodomain inhibitor.
- Improved β-cell function: It can improve β-cell function in a diabetic mouse model.
- HSP90 inhibitor: Bicyclic Isoxazole can act as an HSP90 inhibitor.
- Selective multidrug resistance protein (MRP1) inhibitor: Tricyclic Isoxazole shows promise as a selective MRP1 inhibitor.
Medchemexpress LLC JMJD1C-IN-1 | 861224-48-8 | 99.99% | 317.36 | 25 MG
JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC50 = 0.59 μM, Kd = 1.96 μM). It inhibits the binding of JMJD1C to H3K9me2 peptide substrate and disrupts intratumoral regulatory T (Treg) cell fitness by promoting H3K9me2 accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. It demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models and can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells.
- Orally active and selective inhibitor of JMJD1C.
- Disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms.
- Demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models.
- Can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells.
Selleck Chemical LLC SOP1812 E1982-25MG
SOP1812( QN-302) is a tetra-substituted naphthalene diimide (ND) derivative and selective inhibitor of G-quadruplex (G4) transcription It shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4 9 and 28 4 nM respectively It binds to G-quadruplex DNA in cancer gene promoters region and shows strong anti-proliferative and anti-tumor activity in pancreatic cancer models
Cayman Chemical Aurora Kinase Inhibitor III, Purity: ≥98%, CAS: 879127-16-9, 5 mg
A potent inhibitor of Aurora A kinase (IC50 = 42 nM); selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively)
Medchemexpress LLC Bikinin (Abrasin) | 188011-69-0 | MFCD00116442 | 100.0% | 273.08 g/mol | C9H9BrN2O3 | 10MM 1ML
Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases that activates brassinosteroid (BR) signaling. It is supplied for research use in solution and solid forms, including a ready-to-use 10 mM solution in DMSO, and is reported at high purity for biochemical and plant signaling studies.
- Non-steroidal ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases.
- Activates brassinosteroid signaling pathways.
- Available as a 10 mM solution in DMSO and as solid packs for custom preparation.
- Reported high purity (99.95%) suitable for research applications.
- Documentation available: datasheet, certificate of analysis, safety data sheet, and spectral data.
Medchemexpress LLC HY-W008859 10mg Medchemexpress, Tetrac CAS:67-30-1 Purity:>98%
Medchemexpress, HY-W008859 10mg Tetrac CAS:67-30-1 Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Antitumor agent-159 5mg | 1611446-66-2 | 493.00 | C24H36ClF3N2O3 | 5 MG
Antitumor agent-159 is a small-molecule research compound (CAS 1611446-66-2) reported to modulate mitochondrial metabolism and apoptosis. It is supplied as a 5 mg powder intended for laboratory research and biochemical studies.
- Reported activity on mitochondrial metabolism and apoptosis.
- Molecular formula C24H36ClF3N2O3 and molecular weight 493.00 g·mol-1.
- High reported purity: 99.0% (certificate of analysis).
- Provided as a compact 5 mg quantity suitable for small-scale assays.
- Intended for research use only; not for human, therapeutic, or diagnostic applications.
Medchemexpress LLC RIP2 Kinase Inhibitor 3 | 1398053-50-3 | 99.76% | 388.48 | 10 MG
RIP2 Kinase Inhibitor 3 is a highly potent and selective inhibitor of receptor interacting protein-2 (RIP2) Kinase with an IC50 of 1 nM.
- Highly potent and selective inhibitor of RIP2 Kinase.
- IC50: 1 nM (RIP2).
- Purity: 99.76%.
- Appearance: Solid, light yellow to yellow.
Medchemexpress LLC Berberine ursodeoxycholate | 1868138-66-2 | 99.3% | 727.93 | 100 MG
Berberine ursodeoxycholate is an ionic salt of Berberine and Ursodeoxycholic acid. It is an orally active and potent hypolipidemic agent that significantly reduces liver fat content. This compound exhibits a broad spectrum of metabolic activity.
- Orally active hypolipidemic agent
- Significantly reduces liver fat content
- Exhibits a broad spectrum of metabolic activity
- Can be utilized for research into hyperlipidemia, non-alcoholic steatohepatitis (NASH), and diabetes
AdipoGen Amlodipine besylate (50 mg)
Chemical. CAS: 111470-99-6. Formula: C20H25ClN2O5 . C6H5SO3H. MW: 567.05. Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
Cayman Chemical SB-611812, Purity: ≥98%, CAS: 345892-71-9, 1 mg
An antagonist of UTR; binds to recombinant rat UTR (Ki = 121 nM) and inhibits contraction of isolated rat aorta induced by urotensin II (pA2 = 6.59) but not potassium chloride, endothelin-1, angiotensin II, or phenylephrine; decreases myocardial interstitial fibrosis and the ratio of collagen I to collagen III in a rat model of ischemia induced by ligation of the LAD artery (30 mg/kg)
Cayman Chemical BC-1215, Purity: ≥98%, CAS: 1507370-20-8, 25 mg
An inhibitor of FBXO3 (IC50 = 0.9 μg/mL for Il-1β release); decreases FBXO3-FBXL2 interaction in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2; lowers expression of TRAF1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated PBMCs; reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis when administered at a dose of 100 μg, i.p., per animal; reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema
Medchemexpress LLC 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester | 903550-26-5 | 278.16 | 5 G
This biochemical reagent is suitable as a biological material or organic compound for life science related research. It is intended for research use only and not for sale to patients.
- Appearance: Solid, white to yellow
- Formula: C14H23BN2O3
- Melting point: 74-78°C
- Boiling point: 413.8±35.0 °C at 760 mmHg
- Solubility (in vitro): DMSO: 100 mg/mL (359.50 mM)
- Storage (as supplied): -20°C, sealed, away from moisture
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)
- Shipping: Room temperature in continental US; may vary elsewhere
- Identified uses: Laboratory chemicals, manufacture of substances
- Hazards: Acute toxicity (oral), skin/eye/respiratory irritation
Medchemexpress LLC Urea, N-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxo-3-pyrrolidinyl]-N'-phenyl- | 2253947-47-4 | 99.7% | 250 MG
This compound is a selective, orally active agonist of formyl peptide receptor 2 (FPR2), exhibiting strong agonistic activity in both human and mouse models. It shows promise in attenuating cardiac remodeling after myocardial infarction, suggesting potential for preventing heart failure. Its mechanism involves inhibiting neutrophil chemotaxis and stimulating macrophage phagocytosis, crucial for resolving inflammation. Suitable for in vitro and in vivo research, it demonstrates good oral bioavailability in animal models.
- Selective agonist of formyl peptide receptor 2 (FPR2).
- Highly selective for FPR2 (human EC50 0.41 nM, mouse EC50 3.4 nM).
- Inhibits neutrophil chemotaxis; promotes macrophage phagocytosis.
- Attenuates cardiac remodeling after myocardial infarction.
- Orally active with 24% bioavailability in mice.
- Purity: 99.74%.
- Molecular formula: C18H17F2N3O3.
- Molecular weight: 361.34.