Bioactive Small Molecules
Cayman Chemical ANTIBODY ML-396 1mg
A positive allosteric modulator of group III mGluRs (EC50s = 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays); potentiates LSP4-2022-induced reductions in fEPSP slopes in mouse hippocampal slices; restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome at 30 mg/kg
QA Bio Inc Ludger A2F Glycan - 20µg
A2F Glycan Synonyms: A2 N-linked oligosaccharide. G2FS2, FA2G2S2, F(6)A2G(4)2S(6)2. • Description: Di-sialylated, core-fucosylated bi-antennary complex-type N-glycan (oligosaccharide). • Molecular Weight: 2370 • Purity: >90% pure as assessed by a combination of 1 H-NMR and HPLC. • Sources: A2F glycan is found on many mammalian glycoproteins including thyroglobulin, gamma globulins, and IgG. This product is typically purified from the oligosaccharide pool released from porcine thyroglobulin by hydrazinolysis using a combination of HPLC and glycosidase digestion. • Form: Dry. Dried by centrifugal evaporation from an aqueous solution. Contains ammonium salt to stabilise against desialylation.
Apexbio Technology LLC JNJ-10229570 524923-88-4 1mg
JNJ-10229570 (CAS 524923-88-4) is a selective antagonist of melanocortin receptors MC1R and MC5R It inhibits ligand binding to MC1R and MC5R in human cells with reported inhibition values of 270 nM and 200 nM respectively Through antagonism of these receptors JNJ-10229570 suppresses sebocyte differentiation and the biosynthesis of cortex-specific lipids This compound serves as a valuable tool for investigating the roles of melanocortin signaling in lipid metabolism and sebaceous gland physiology
Medchemexpress LLC Oxyphenbutazone monohydrate | 7081-38-1 | 98.0% | 5 MG
Oxyphenbutazone monohydrate is a Phenylbutazone metabolite that exhibits anti-inflammatory effects. This orally active, non-selective COX inhibitor can selectively kill non-replicating Mycobacterium tuberculosis. It also enhances the anticancer efficiency of Methotrexate in Hep3B cells and exhibits reparative effects in hepatocytes.
- Phenylbutazone metabolite with anti-inflammatory properties
- Orally active non-selective COX inhibitor
- Selectively kills non-replicating Mycobacterium tuberculosis
- Enhances anticancer efficiency in Hep3B cells
- Exhibits reparative effects in hepatocytes
Selleck Chemical LLC Momordica grosvenori Extract E3438-5MG
Momordica Grosvenori Extract is extracted from Siraitia grosvenorii which has antidiabetic effects by upregulating HO-1 and can be used for the treatment of diabetes
Medchemexpress LLC Akt1-IN-1 | 99.7% | 637.74 | 25 MG
Akt1-IN-1 is a potent and selective Akt1 inhibitor with an IC50 value of 18.79 nM in MIA Paca-2 cells. It does not exhibit obvious teratogenicity, hepatotoxicity, and cardiotoxicity. This compound can be used for researching anticancer. It is for research use only and not sold to patients.
- Potent and selective Akt1 inhibitor
- IC50 value of 18.79 nM in MIA Paca-2 cells
- Does not exhibit obvious teratogenicity
- Does not exhibit obvious hepatotoxicity
- Does not exhibit obvious cardiotoxicity
- Suitable for researching anticancer
Selleck Chemical LLC KB-0742 Dihydrochloride S9901-25MG
KB-0742 Dihydrochloride is a potent selective and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 M ATP
Medchemexpress LLC Cibenzoline | 53267-01-9 | MFCD00864706 | 95.1% | 262.35 | C18H18N2 | 10 MG
Cibenzoline is an analytical reference standard of a class Ia antiarrhythmic imidazoline compound intended for research and analytical applications. It is provided for use in qualitative and quantitative assays and method development for chromatographic and mass spectrometric workflows.
- Analytical reference standard for HPLC, GC, and MS assays.
- Suitable for qualitative and quantitative method development.
- Used in pharmacology and ion channel research applications.
- Molecular formula C18H18N2; molecular weight 262.35.
- Reported purity approximately 95.1% (manufacturer documentation).
Medchemexpress LLC Tofacitinib impurity 2 | 95.4% | 436.69 | 50 MG
Tofacitinib impurity 2 is an impurity of Tofacitinib. It is for research use only and not sold to patients. The product appears as a liquid and should be shipped at room temperature in the continental US, with storage at 4°C, protected from light. In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month (protected from light).
- Impurity of Tofacitinib
- For research use only
- Appears as a liquid
- Ships at room temperature in continental US
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month (protected from light)
Cayman Chemical ANTIBODY DaphntIn 100mg
A coumarin derivative with diverse biological activities; inhibits EGFR, PKA, and PKC in vitro (IC50s = 7.67, 9.33, and 25.01 µM, respectively); inhibits cell proliferation (IC50 = 73 µM) in MCF-7 breast carcinoma cells; decreases the generation of ROS and production of MDA and increases SOD activity and the GSH:GSSG ratio in RAW 264.7 cells; prevents t-BHP-induced cytotoxicity and ROS overproduction in wild-type, but not Nrf2-/-, RAW 264.7 cells and increases the expression of proteins downstream of Nrf2
Cayman Chemical ANTIBODY PKI-166 10mg
An inhibitor of EGFR (IC50 = 0.0007 µM for the intracellular kinase domain); selective for the EGFR intracellular kinase domain over the serine/threonine kinases PKC-α and Cdc2/cyclin B (IC50s = >100 and 78 µM, respectively), as well as FLK, c-Met, and Tek (IC50 = >1 µM for all), but does inhibit c-Src, c-Abl, VEGFR2/KDR, FLT1, and c-Kit (IC50s = 0.103, 0.028, 0.327, 0.962, and 2.21 µM, respectively); enhances the cytotoxicity of gemcitabine in L3.6pl cells; reduces tumor growth and metastasis and increases survival in an L3.6pl mouse xenograft model at 100 mg/kg per day with additive effects when administered in combination with gemcitabine; reduces tumor growth and inhibits angiogenesis in an SN12-PM6 human renal cell carcinoma mouse orthotopic model
![Medchemexpress LLC 3-[[(3,4-dichlorophenyl)amino]carbonyl]-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid | 199735-88-1 | >98.0% | 326.17 g/mol | C15H13Cl2NO3 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242469.png-250.jpg)
Medchemexpress LLC 3-[[(3,4-dichlorophenyl)amino]carbonyl]-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid | 199735-88-1 | >98.0% | 326.17 g/mol | C15H13Cl2NO3 | 25 MG
CADD522 is a small-molecule inhibitor of RUNX family transcription factor 2 (RUNX2) DNA binding used for research in cancer biology. It inhibits RUNX2 binding in cell-free and cellular assays, downregulates RUNX2 target genes, reduces clonogenic survival in breast cancer cell lines, and has shown antitumor activity in mouse models. For research use only.
- Inhibits RUNX2-DNA binding in cell-free and cellular assays.
- Reduces expression of RUNX2 target genes such as MMP-13 and VEGF.
- Decreases clonogenic survival in multiple breast cancer cell lines.
- Demonstrated tumor volume reduction in mouse tumor models.
- High purity suitable for biological studies (≥98%).
- Recommended storage as a solid at -20°C; long-term in solvent at -80°C.
Selleck Chemical LLC Protamine sulfate P1169-100MG
Protamine sulfate is a polycationic highly positively charged protein derived from salmon sperm protein used to neutralize unfractionated heparin administration (UFH)-induced anticoagulation following cardiovascular surgical procedures
Selleck Chemical LLC Rupatadine E7255-50MG
Rupatadine (UR-12592) is a potent orally active and long-lasting dual PAF/H1 antagonist with Kis of 0 55 M and 0 1 M respectively Rupatadine can be used for the research of allergic rhinitis and urticaria
Cayman Chemical ANTIBODY UTL-5g 50mg
A chemo- and radioprotective agent; reduces LPS-induced transcriptional activity mediated by a variety of immune-related transcription factors, including STAT1, STAT2, STAT3, and SMAD2-4 but not NF-κB in RAW 264.7 macrophages; reduces radiation-induced increases in liver TNF-α levels in mice at 30 and 60 mg/kg; protective against liver radiation-induced hepatotoxicity in mice at 60 mg/kg; increases the survival rate in a mouse model of acute cisplatin toxicity