Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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7,396 – 7,410 of 60,533 results

7,396

Cayman Chemical (−)-Gallocatechin, Purity: ≥98%, CAS: 3371-27-5, 5 mg

An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM)

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7,397

Cayman Chemical ML-324, Purity: ≥95%, CAS: 1222800-79-4, 1 mg

A cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM); reduces the expression of immediate early genes of HSV (IC50 = ~10 µM) and hCMV, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice

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7,398

Cayman Chemical ANTIBODY RAD140 500ug

An orally bioavailable SARM that binds to the androgen receptor with a Ki value of 7 nM; stimulates muscle weight increase without affecting prostate or seminal vesicle in castrated male rats

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7,399

Cayman Chemical (±)-Atenolol, Purity: ≥98%, CAS: 29122-68-7, 5 g

A β1-AR antagonist (Ki = 1.14 µM); selective for β1-ARs over β2-ARs (Ki = 48.7 µM); delays the onset of hypertension in spontaneously hypertensive rats at 200 mg/kg

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7,400

Cayman Chemical ML-031, Purity: ≥95%, CAS: 852230-33-2, 10 mg

One of the first indentified agonists of S1P2 demonstrating an EC50 value of 1 μM in a S1P reporter assay

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7,401

Cayman Chemical (R)-(+)-BAY-K-8644, Purity: ≥95%, CAS: 98791-67-4, 10 mg

An L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM

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7,402

Cayman Chemical Tigecycline, Purity: ≥98%, CAS: 220620-09-7, 5 mg

A glycylcycline antibiotic; binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth; active against a panel of 1,924 European clinical bacterial isolates (MICs = C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection at 6.25 mg/kg twice daily for 5 days

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7,403

Cayman Chemical CYM 5541, Purity: ≥98%, CAS: 945128-26-7, 50 mg

A selective agonist of S1P3 (EC50 = 72-132 nM); less effectively activates S1P1 (EC50 = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters

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7,404

Cayman Chemical JNJ-26854165, Purity: ≥98%, CAS: 881202-45-5, 1 mg

An antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM); orally bioavailable, having anti-proliferation as well as apoptotic actions in various tumor models; affects multiple signaling pathways

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7,405

Cayman Chemical MNS, Purity: ≥95%, CAS: 1485-00-3, 100 mg

Blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619, and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively); reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM, respectively) in vitro

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7,406

Cayman Chemical JW 55, Purity: ≥98%, CAS: 664993-53-7, 5 mg

An inhibitor of the PARP domain of TNKS1 and TNKS2 (IC50s = 1.9 and 0.83 µM, respectively); decreases canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and reduces proliferation of SW480 cells in vitro

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7,407

Cayman Chemical Torcetrapib, Purity: ≥98%, CAS: 262352-17-0, 5 mg

A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg

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7,408

Cayman Chemical CD2665, Purity: ≥98%, CAS: 170355-78-9, 1 mg

A selective RARβ and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα)

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7,409

Cayman Chemical JFD00244, Purity: ≥95%, CAS: 96969-83-4, 10 mg

An inhibitor of SIRT2 (IC50= 56.7 µM); induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4

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7,410

Cayman Chemical CAY10680, Purity: ≥95%, CAS: 1439488-21-7, 10 mg

A selective inhibitor of both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human); designed as a potential dopamine-sparing therapeutic in the treatment of Parkinson’s disease

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Bioactive Small Molecules

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