Bioactive Small Molecules
Selleck Chemical LLC BMS-754807 S1124-50mg
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1 8 nM/1 7 nM in cell-free assays less potent to Met (c-Met) Aurora A/B TrkA/B and Ron and shows little activity to Flt3 Lck MK2 PKA PKC etc Phase 2
Selleck Chemical LLC LY 345899-E1317-5MG
LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1 DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM respectively It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models
Medchemexpress LLC LY3522348 | 2568608-48-8 | 98.3% | 409.41 | 500 MG
LY3522348 (KHK-IN-3) is a ketohexokinase (KHK) inhibitor. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism, catalyzing the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition in fructose metabolism leads to the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.
- Ketohexokinase (KHK) inhibitor
- Can be used in the study of kidney disease
- Can be used in the study of nonalcoholic steatohepatitis (NASH)
- Can be used in the study of diabetes
- Can be used in the study of heart failure
Cayman Chemical ANTIBODY -Cedrol 100mg
A sesquiterpene alcohol; inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi at 100 μg/ml; inhibits CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively); prevents hair follicle dystrophy and reduces hair loss in a mouse model of cyclophosphamide-induced alopecia at 200 mg/kg; loaded nanostructured lipid particles reduce compound 48/80-induced peritoneal mast cell degranulation in mice
Medchemexpress LLC 1-Benzopyrylium, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, chloride (1:1) | 528-58-5 | MFCD00017582 | 322.70 | 25 MG
Cyanidin Chloride (IdB 1027) is a subclass of anthocyanin that displays antioxidant and anti-carcinogenesis properties. It is known to inhibit osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression.
- Antioxidant properties.
- Anti-carcinogenesis properties.
- Inhibits osteoclast formation.
- Inhibits hydroxyapatite resorption.
- Inhibits RANKL-induced osteoclast marker gene expression.
Medchemexpress LLC PKLR Human HEK293 50ug
Recombinant human pyruvate kinase (PKLR) produced in HEK293 cells and supplied as a filtered, stabilized solution with a C-terminal 6xHis tag for research use. The protein is >95% pure by reducing SDS-PAGE, has an approximate molecular weight of 62.0 kDa, and is provided in microgram-scale quantities for biochemical and assay applications.
- Expressed in HEK293 cells with a C-terminal 6xHis tag.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Approximate molecular weight 62.0 kDa.
- Supplied in a stabilized formulation with glycerol, trehalose, and buffering salts.
- Stored at -80°C and shipped on dry ice; avoid repeated freeze-thaw.
- Available in small microgram quantities suitable for biochemical assays and reagent use.
TARGETMOL CHEMICALS INC GALLOFLAVIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 uM and 15.06 uM respectively. Galloflavin is also a potential anticancer agent. purity: 96%
AdipoGen Antibiotic PF 1052
Chemical. CAS 147317-15-5. Formula C26H39NO4. MW 429.6. Isolated from Phoma sp. Antibiotic. Antibacterial, antifungal and phytotoxic.
TARGETMOL CHEMICALS INC CDK9-IN-7 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50 11 nM) which exhibits more potent over other CDKs (CDK4/cyclinD 148 nM; CDK6/cyclinD 145 nM). purity: 98%
Medchemexpress LLC Azamethiphos 10mM 1mL | 35575-96-3 | 324.68 g/mol | C9H10ClN2O5PS | 1 ML
Azamethiphos is an organophosphate insecticide and acetylcholinesterase (AChE) inhibitor supplied as an analytical standard for laboratory research. The product is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and is also available in solid quantities for analytical and toxicology studies. For research use only; not for human use.
- Organophosphate acetylcholinesterase inhibitor.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Also available as solid in 100 mg-1 g sizes.
- Purity 96.46% as listed.
- Molecular weight 324.68 g/mol; formula C9H10ClN2O5PS.
- Intended for analytical, assay, and toxicology applications.
Medchemexpress LLC Purinostat mesylate | 2650188-32-0 | 99.45% | 586.62 | 50 MG
Purinostat mesylate is a selective inhibitor of HDACs, specifically inhibiting class I and class IIb HDACs. It is suitable for research related to lymphoblastic leukemia, demonstrating potent anti-leukemia effects in vivo by inducing apoptosis and affecting the cell cycle of LAMA84 and 188 BL-2 cells.
- Selective inhibitor of class I and class IIb HDACs
- Induces apoptosis in LAMA84 and 188 BL-2 cells
- Affects cell cycle progression
- Demonstrates potent anti-leukemia effects in vivo
- Useful for research on lymphoblastic leukemia
Medchemexpress LLC N-(9-fluorenylmethoxycarbonyl)-glycine-2,2-d2 | 284665-11-8 | MFCD01075436 | 99.5% | 299.32 g/mol | C17H13D2NO4 | 100mg
Fmoc-Gly-OH-2 2-d2 (Fmoc-glycine-2 2-d2) is the deuterium labeled Fmoc-Gly-OH (HY-Y1250) Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative can be used for the synthesis of compounds[1]
Cayman Chemical ANTIBODY STX140 5mg
An estrogen sulfamate with anticancer activities; inhibits steroid sulfatase (IC50s = 39 and 0.5 nM in placental microsomes and MCF-7 cancer cells, respectively); binds to carbonic anhydrase IX and II (Kis = 70 and 270 nM, respectively); inhibits bovine brain tubulin assembly in a cell-free assay (IC50 = 2.2 µM) and tubule formation in HUVECs at 50 and 100 nM; inhibits proliferation of LNCaP, PC3, and MDA-MB-231 cancer cells, as well as wild-type A2780 cancer cells and adriamycin- and cisplatin-resistant A2780 cancer cells (IC50s = 530, 400, 618, 330, 870, and 380 nM, respectively); reduces angiogenesis in a Matrigel™ plug assay in mice and tumor growth in MCF-7 and MDA-MB-231 mouse xenograft models at 20 mg/kg
Medchemexpress LLC 2,3-dihydrobenzofuran-6-ol | 23681-89-2 | MFCD18378253 | 500mg
2 3-Dihydrobenzofuran-6-ol is a drug impurity
Medchemexpress LLC N'-(2-(4-Chlorophenoxy)benzo[d]thiazol-6-yl)-N,N-diethylformimidamide | 99.6% | 359.87 | 25 MG
N'-(2-(4-Chlorophenoxy)benzo[d]thiazol-6-yl)-N,N-diethylformimidamide | 99.6% | 359.87 | 25 MG