Bioactive Small Molecules
Cayman Chemical ANTIBODY FDW028 25mg
A FUC8 inhibitor; binds to FUC8 (Kd = 5.486 µM) and inhibits core fucosylation in HCT-8 and SW480 CRC cells; induces degradation of B7-H3 via CMA in the same cells at 50 µM; reduces tumor volume and increases survival in an SW480 mouse xenograft model at 10 and 20 mg/kg
Medchemexpress LLC Jb061 | C19H17NO4 | 1 ML
JB061 is a nonmuscle myosin inhibitor known for its specific inhibition of various myosin types and its cytotoxic effects on COS-7 cells. It effectively inhibits cytokinesis in Cos-7 cells.
- Nonmuscle myosin inhibitor
- Inhibits cytokinesis in Cos-7 cells
- High purity (99.27%)
- Solid appearance, white to off-white color
- Stable storage conditions for powder and in solvent
Cayman Chemical Nargencn 5mg
A macrolide antibiotic that is selective for S. aureus, MRSA, and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml); inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE at 0.00001-0.1 and 0.01-100 μg/mL, respectively; inhibits LPS-induced cytokine expression and nitric oxide production in murine BV-2 cells at 1 μM; reduces HL-60 cell proliferation increases cell differentiation when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid at 200 μM; reduces the number of CFUs in infected kidneys by 100,000-fold in a murine model of S. aureus infection at 50 mg/kg, p.o
Cayman Chemical ANTIBODY TropIfexor 5mg
An FXR agonist; enhances the interaction between the human FXR ligand binding domain and the SRC-1 peptide in an HTRF coactivator interaction assay (EC50 = 0.2 nM); increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum; reduces triglyceride levels by 79% in rat serum at 0.3 mg/kg; reduces fibrosis, inflammation, and steatosis in a mouse model of NASH
Medchemexpress LLC (2S,3R,4S)-4-Hydroxyisoleucine | 55399-93-4 | 98.0% | 147.17 | 50 MG
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from *Trigonella foenum-graecum*. It exhibits anti-diabetic and anti-diabetic nephropathy activity, significantly increasing insulin release in isolated rat pancreatic islets and showing non-insulin dependent anti-diabetic activity in type I diabetic rats. It induces a reduction in blood glucose, restores diabetic lipid profiles, reverses HDL changes, and reduces hyperuricemia.
- Significantly increases insulin release
- Demonstrates anti-diabetic activity
- Restores diabetic lipid profile
- Reduces increased hyperuricemia
- Isolated from *Trigonella foenum-graecum*
Apexbio Technology LLC Progesterone 57-83-0 5g
Progesterone (57-83-0) is a steroid hormone that modulates reproductive processes by specifically interacting with its nuclear receptors It is designed to regulate embryo implantation and endometrial physiology thereby influencing estrogenic signaling and target gene expression in reproductive tissues Progesterone exerts its biological activity primarily through attenuation of estrogenic signaling affecting genes such as Egr1 In in vitro studies progesterone demonstrates the ability to restrict cell proliferation pathways in melanoma models including B16F10 mouse cells and BLM human cell lines Additionally progesterone regulates mammary carcinoma progression via RANKL-dependent activation of signaling components such as GLI-1 Based on these pharmacological properties progesterone holds research potential in studies of hormonal regulation reproductive biology cancer progression and neuroprotection
Medchemexpress LLC 4-(4-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)phenoxy)-N-methylpicolinamide | 99.3% | 386.41 | 5 MG
Smurf1 ligand 1 is a PROTAC target protein ligand. It can be used for the synthesis of SMART1.
- Purity: 99.31%
- Molecular weight: 386.41
- Unit of measure: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg
Medchemexpress LLC Tiplaxtinin | 393105-53-8 | C24H16F3NO4 | 10 MM 1 ML
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 2.7 μM.
- Selective and orally efficacious inhibitor of PAI-1.
- IC50 of 2.7 μM for PAI-1.
- Inhibits cellular proliferation in T24 cells and UM-UC-14 cells.
- Reduces thrombus weight in a rat model of thrombosis.
- Reduces subcutaneous tumor growth in human bladder cancer and human cervical cancer xenografts.
Cayman Chemical ANTIBODY ML-18 10mg
A BB3 receptor antagonist; inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM); selective for BB3 over GRPR and NMBR (IC50s = 16 and >100 μM, respectively, in a radioligand binding assay); reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells at 16 μM; inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells
Cayman Chemical 1-MSHhumnmouseratbo 5mg
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo at 0.01 nmol/animal
Cayman Chemical ANTIBODY ML-192 10mg
A selective GPR55 antagonist (IC50 = 702 nM); selective for GPR55 over CB1 and CB2, as well as GPR35 (IC50s = >32 μM)
Medchemexpress LLC Hy-125880 | 1849603-72-0 | 99.7% | 450.55 g·mol⁻1 | C26H31FN4O2 | 25MG
SBI-553 is a small-molecule, brain-penetrant, β-arrestin-biased positive allosteric modulator of the neurotensin receptor 1 (NTR1), reported in the medicinal chemistry literature with an EC50 of about 0.34 μM. The compound is supplied for research use and is used in preclinical pharmacology and receptor signaling studies.
- Potent NTR1 allosteric modulator with β-arrestin-biased activity.
- Brain penetrant and reported to be orally bioavailable in preclinical studies.
- Reported EC50 ≈ 0.34 μM for NTR1 modulation.
- High chemical purity suitable for research use.
- Available in multiple small pack sizes for laboratory use.
- Chemical formula C26H31FN4O2; molecular weight 450.55 g·mol⁻1.
Cayman Chemical ANTIBODY XMU-MP-1 1mg
An inhibitor of MST1 and MST2 (IC50s = 71.1 and 38.1 nM, respectively); is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM; inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner; prevents cell death induced by overexpression of MST2; enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury when administered at a dose of 1 mg/kg
AdipoGen Ebselen (25 mg)
Chemical. CAS: 60940-34-3. Formula: C13H9NOSe. MW: 274.2. Glutathione peroxidase mimetic. Peroxynitrite scavenger. Anti-inflammatory Antioxidant. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor. Antifungal. Review. Potent IDO-1 inhibitor with Ki 94nM. Inhibitor of HIV-1 capsid C-terminal domain dimerization.
Selleck Chemical LLC MTX-531 E4680-25MG
MTX-531(NSC827271) is a first-in-class potent and selective inhibitor of EGFR and PI3K with an IC50 of 14 7 nM and 6 4 nM respectively It may play a role in treating Head and Neck Squamous Cell Carcinoma (HSNCC) squamous lung cancers and certain EGFR/PI3K-driven triple-negative breast cancers