Bioactive Small Molecules
Medchemexpress LLC DW71177 | 2241311-72-6 | 97.7% | 384.48 | 50 MG
DW71177 is a novel triazolo[4,3-a] quinoxaline-based potent and BD1-Selective BET inhibitor. It can be used for the study of acute myeloid leukemia.
- Novel triazolo[4,3-a] quinoxaline-based compound
- Potent and BD1-selective BET inhibitor
- Can be used for the study of acute myeloid leukemia
Medchemexpress LLC CYN 154806 (TFA) | 2828432-46-6 | 98.3% | 1311.36 | 10 MG
CYN 154806 TFA is a cyclic octapeptide and a potent, selective somatostatin sst2 receptor antagonist.
- Potent and selective somatostatin sst2 receptor antagonist
- Exhibits pIC50 values for human recombinant sst2, sst1, sst3, sst4, and sst5 receptors
- Inhibits SRIF-induced increases in extracellular acidification
- Blocks SRIF-induced increases in [35S]-GTPγS binding
- Reverses decreased acid response to CCh in M4 KO mice
Cayman Chemical ANTIBODY CXD101 500ug
An HDAC1, HDAC2, and HDAC3 inhibitor (IC50s = 63, 570, and 550 nM, respectively); increases H3K9Ac in Colon-26 cells at 2.7 µM; decreases tumor volume, reduces tumor levels of macrophages, and increases tumor levels of Cd4+ and Cd8+ T cells in a Colon-26 murine colon cancer model at 50 mg/kg per day; increases serum levels of IgG and IgM antibodies thirty days after administration in mice immunized with the SARS-CoV-2 spike glycoprotein
Medchemexpress LLC Alpha-D-Glucopyranoside, 6-thio-alpha-D-glucopyranosyl 6-thio- | 1285607-08-0 | 99.9% | 374.43 | 25 MG
Fexlamose (AER-01) is a thiol-modified carbohydrate agent with mucolytic properties. It functions by cleaving disulfide bonds to cause mucolysis. This agent is used for research into chronic obstructive pulmonary disease (COPD) and muco-obstructive lung diseases (MOLD).
- Thiol-modified carbohydrate agent.
- Cleaves disulfides to cause mucolysis.
- Applicable for research in chronic obstructive pulmonary disease (COPD).
- Applicable for research in muco-obstructive lung diseases (MOLD).
- In-vivo studies show it decreases airway mucus plugging.
- In-vivo studies show it lessens airway inflammation.
- In-vivo studies show it improves survival in muco-obstructive lung disease.
Cayman Chemical 1,2-Distearoyl-3-Butyryl-rac-glycerol, Purity: ≥98%, CAS: 139665-43-3, 5 mg
A triacylglycerol; has been found in butterfat
Medchemexpress LLC Zolucatetide (FOG-001; I-66) | 3044032-95-0 | 98.23% | 2076.39 | 50 MG
Zolucatetide (FOG-001; I-66) | 3044032-95-0 | 98.23% | 2076.39 | 50 MG
Medchemexpress LLC Adiponectin receptor protein 1 Antibody (YA2700) | 100 UL
The MedChemExpress Adiponectin receptor protein 1 Antibody (YA2700) is a rabbit-derived antibody supplied as a liquid, primarily for research applications. This non-conjugated antibody has a molecular weight of 43 kDa and is suitable for various laboratory uses.
- Reacts with human, mouse, and rat samples
- Stable for 1 year when stored at -20°C
- Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Recommended for Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF), and Flow Cytometry (FC)
- Shipped with blue ice
- Avoid repeated freeze/thaw cycles
Apexbio Technology LLC GDC-0941 dimethanesulfonate 957054-33-0 200mg
GDC-0941 dimethanesulfonate (CAS 957054-33-0) is a thieno[3 2-d]pyrimidine-based small molecule inhibitor targeting class I phosphoinositide 3-kinases (PI3K) It competitively binds the ATP-binding site of PI3K thereby suppressing synthesis of phosphatidylinositol-3 4 5-trisphosphate (PIP3) and downstream Akt signaling a pathway frequently dysregulated in cancer GDC-0941 exhibits high selectivity for PI3K and PI3K isoforms (IC50 3 nM) with moderate selectivity toward PI3K and PI3K In vitro and in vivo studies show inhibition of proliferation in various cancer cell lines including HER2-amplified and drug-resistant models and reduction of tumor volume in xenograft models GDC-0941 is orally bioavailable and serves as a valuable tool for exploring PI3K pathway function in oncology research
Medchemexpress LLC Simvastatin acid | 121009-77-6 | 95.5% | 25 MG
Simvastatin acid is the hydrolyzed, active form of simvastatin and a potent HMG-CoA reductase inhibitor used in biochemical and cellular research. It has reported effects on reactive oxygen species and OATP3A1 expression in cardiomyocyte models.
- Active hydrolyzed form of simvastatin
- Inhibits HMG-CoA reductase (HMGCR)
- Reduces indoxyl sulfate-mediated reactive oxygen species in cardiomyocytes
- Available as a 25 mg research-grade solid
- Includes analytical documentation such as COA, HNMR, LCMS, and RP-HPLC
Cayman Chemical BKT 140, Purity: ≥95%, CAS: 664334-36-5, 1 mg
A CXCR4 antagonist (IC50 = 0.91 nM); inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 = 4 nM); reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM; induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 µM; reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis
Medchemexpress LLC Macupatide | 2923558-68-1 | >99.95% | 4984.60 | 10 MG
Macupatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It improves insulin secretion responses and insulin sensitivity, making it suitable for the research of type 2 diabetes.
- Improves insulin secretion responses
- Enhances insulin sensitivity
- Produces larger insulin sensitivity improvement compared with selective GLP-1 RA Dulaglutide
- Combination therapy with Dulaglutide has additive effects on insulin sensitivity
Medchemexpress LLC Bryodulcosigenin | 88930-16-9 | 1 MG
Bryodulcosigenin is an extract from the roots of Bryonia dioica with an anti-inflammatory effect. It is a solid, white to off-white compound with 99.21% purity and a molecular weight of 474.72. It is classified as a terpenoid triterpene.
- Purity: 99.21%
- Molecular weight: 474.72
- Formula: C30H50O4
- Soluble in DMSO (100 mg/mL, requires ultrasonic)
- Can be prepared for in vivo dissolution in 10% DMSO and 90% (20% SBE-β-CD in Saline) or 10% DMSO and 90% Corn Oil.
Selleck Chemical LLC S-Nitrosoglutathione E4443-25MG
S-nitrosoglutathione (GSNO RVC-588 S-Nitroso-L-glutathione Nitrosoglutathione) is an amino acid and nitric oxide donor that under physiological conditions spontaneously releases nitric oxide S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF- B activation It induces apoptosis in T cells in low concentrations ( 0 6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM)
![Medchemexpress LLC 4H-Furo[3,2-b]pyrrole-5-carboxylic acid | 67268-37-5 | MFCD07368660 | 99.4% | 151.12 g·mol⁻¹ | C7H5NO3 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000300306.png-250.jpg)
Medchemexpress LLC 4H-Furo[3,2-b]pyrrole-5-carboxylic acid | 67268-37-5 | MFCD07368660 | 99.4% | 151.12 g·mol⁻¹ | C7H5NO3 | 500 MG
SEP-227900 is a research-grade small molecule described as an endogenous metabolite and reported to act as a D-amino acid oxidase (DAAO) inhibitor. It has molecular formula C7H5NO3, a molecular weight of 151.12 g·mol⁻¹, and is supplied with high reported purity for laboratory research and analytical applications.
- High purity suitable for analytical and biological assays.
- Characterized chemical identity with CAS 67268-37-5.
- Available in multiple pack sizes to support varied experimental scales.
- Documented quality with datasheet and certificate of analysis.
- Stable under recommended storage and handling conditions.
Cayman Chemical [Ser159]-PKCε (149-164) (trifluoroacetate salt), Purity: ≥98%, 5 mg
A peptide substrate for PKCγ, PKCδ, PKCε, PKCη, and PKCξ; has been used as a target substrate for the quantification of PKCγ, PKCδ, PKCε, PKCη, or PKCξ activity in cell-free or cell-based assays