Protein Modification Reagents
Medchemexpress LLC Methyl-PEG4-NHS ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 g/mol | C14H23NO8 | 500MG
m-PEG4-NHS ester is a methoxy-terminated polyethylene glycol (PEG4) linker bearing an N-hydroxysuccinimide (NHS) ester that enables efficient conjugation to primary amines. It is used as a spacer in bifunctional molecules and for labeling proteins or small molecules in synthesis workflows, offering improved solubility and flexible spacing.
- Reactive NHS ester for rapid coupling to primary amines.
- Methoxy-terminated PEG4 spacer to increase solubility and reduce aggregation.
- Approximately 333.33 g/mol molecular weight for predictable stoichiometry.
- High purity suitable for synthetic and bioconjugation applications.
- Available in multiple laboratory-scale quantities for flexible workflow planning.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 5 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker that contains a maleimide reactive group, a four-unit polyethylene glycol (PEG4) spacer, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer. It is used in the synthesis of ADCs to enable protease-triggered release of cytotoxic payloads.
- Cleavable linker for protease-triggered payload release.
- Contains maleimide functional group for thiol conjugation.
- PEG4 spacer to improve solubility and reduce aggregation.
- Val-Cit-PAB motif enables self-immolation and controlled payload release.
- High purity (98.9%) and characterized molecular weight 777.86.
- Available in a 5 mg vial for research use.
(C)C(C)(C)C)OCCC#N | 500mg | 550804124](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203158.JPG-250.jpg)
eMolecules 1807521-08-9 | TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124
TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | 1807521-08-9 | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124
Medchemexpress LLC 3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid | 1429934-37-1 | ≥97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker and a click chemistry reagent. It contains an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide group-containing molecules. This linker is crucial for synthesizing PROTACs, which utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAc reactions
- Enables targeted protein degradation
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.40% | 250 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTAC molecules incorporate two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, while the other targets the desired protein. This mechanism enables PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Purity of 98.40%
- Solid appearance
Medchemexpress LLC m-PEG4-Hydrazide | 1449390-68-4 | C10H22N2O5 | 1 G
m-PEG4-Hydrazide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are chemical compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Designed for selective degradation of target proteins
Medchemexpress LLC Nh-bis(peg4-c2-nh-boc) | 2182601-75-6 | ≥97.0% | C30H61N3O12 | 500 MG
NH-bis(PEG4-C2-NH-Boc) is a PEG-based linker utilized in PROTAC synthesis, appearing as a colorless to light yellow liquid. This compound is intended for research use only and has not been fully validated for medical applications.
- PEG-based linker for PROTAC synthesis.
- Purity of at least 97.0% as determined by NMR.
- Stable when stored at -20°C for up to 3 years or 4°C for up to 2 years in pure form.
- Maintain stability for up to 6 months at -80°C or 1 month at -20°C when in solvent.
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 5 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for bioconjugation and ADC synthesis. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and provides a terminal carboxylic acid for covalent coupling. Supplied as a high-purity liquid for research applications.
- Cleavable PEG4 linker for bioconjugation.
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC).
- Terminal carboxylic acid for amide coupling.
- High reported purity (99.3%).
- Liquid, colorless to light yellow; store frozen for long-term stability.
- For research use only; not for human therapeutic use.
Medchemexpress LLC T-Boc-N-amido-PEG5-tosylate | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 g/mol | C22H37NO9S | 1 G
A Boc-protected PEG5 tosyl linker for chemical conjugation and linker assembly. The reagent combines a hydrophilic five-unit polyethylene glycol spacer with a tosylate leaving group and a Boc-protected amine, providing improved solubility and enabling nucleophilic substitution for installation of PEG-based linkers in medicinal chemistry and bioconjugation workflows.
- Enhances aqueous solubility via PEG5 spacer.
- Enables nucleophilic substitution through tosylate leaving group.
- Protects primary amine with Boc for selective deprotection.
- Suitable for linker assembly and bioconjugation chemistry.
- Compatible with standard organic synthesis conditions.
Medchemexpress LLC DSPE-PEG-folate | 95.7% | 5000 (Average) | 10 MG
DSPE-PEG-Folate, MW 5000 is a pegylated phospholipid composed of distearoyl phosphatidylethanolamine (DSPE) conjugated to polyethylene glycol terminated with folic acid. It is used to impart folate-receptor targeting to liposomes, micelles, and other nanocarriers for targeted drug delivery and receptor-specific binding studies.
- Enables folate-receptor mediated targeting of nanocarriers.
- Average PEG molecular weight of 5000 provides an extended hydrophilic spacer.
- Integrates into lipid bilayers and forms stable micelles.
- High purity suitable for research applications.
- Available in small research pack sizes for formulation studies.
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 50 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent for biochemical research. It enables covalent conjugation via azide-alkyne cycloaddition and is commonly used to functionalize liposomes, nanoparticles, and biomolecules for labeling or targeted delivery applications.
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free reactions.
- Suitable for liposome and surface functionalization in biochemical studies.
- Supplied as a white to off-white solid with high purity.
- Soluble in DMSO (12.5 mg/mL) with sonication and heating.
- Recommend sealed storage at 4°C; in solution: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Tamra-peg3-azide | 1228100-59-1 | MFCD28334528 | 96.0% | 630.69 | C33H38N6O7 | 5MG
TAMRA-PEG3-Azide is a red-fluorescent dye derivative of 5-carboxytetramethylrhodamine bearing a three-unit polyethylene glycol (PEG3) linker and a terminal azide group. Supplied as a solid for research use, it enables bioconjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), allowing fluorescent labeling of alkyne-containing biomolecules.
STA Pharmaceutical Fmoc-NH-PEG6-CH2CH2COOH | 25 g | CAS 882847-34-9 | MDL MFCD06656474
Fmoc-NH-PEG6-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 882847-34-9
- MDL: MFCD06656474
- InChIKey: HEGZERUHBVYZPH-UHFFFAOYSA-N
- Molecular Weight: 575.655
- Molecular Formula: C30H41NO10
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC TCO-PEG2-amine | 2141981-87-3 | ≥97.0% | C15H28N2O4 | 50 MG
TCO-PEG2-amine is a PEG-based PROTAC linker. This compound is used in the synthesis of PROTACs.
- Purity of ≥97.0%
- Molecular formula C15H28N2O4
- Molecular weight 300.39
- Appears as a colorless to light yellow liquid
- Recommended storage at 4°C, protected from light
- Suitable for PROTAC synthesis
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 250 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Designed for selective degradation of target proteins