Protein Modification Reagents
ABclonal Technology HNF3/FOXA2 Rabbit mAb
This gene encodes a member of the forkhead class of DNA-binding proteins These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin and they also interact with chromatin Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver This gene has been linked to sporadic cases of maturity-onset diabetes of the young Transcript variants encoding different isoforms have been identified for this gene
![eMolecules Broadpharm / APN-C3-PEG4-alkyne / 5mg / 374905429 / BP-23869 / 98.000 / 2183440-36-8 / [null] / 469.538 / C25H31N3O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502471121.JPG-250.jpg)
eMolecules Broadpharm / APN-C3-PEG4-alkyne / 5mg / 374905429 / BP-23869 / 98.000 / 2183440-36-8 / [null] / 469.538 / C25H31N3O6
Broadpharm / APN-C3-PEG4-alkyne / 5mg / 374905429 / BP-23869 / 98.000 / 2183440-36-8 / [null] / 469.538 / C25H31N3O6
![Medchemexpress LLC Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxamide | 412319-45-0 | 98.1% | 576.55 g·mol⁻¹ | C29H28N4O9 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000223507.png-250.jpg)
Medchemexpress LLC Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxamide | 412319-45-0 | 98.1% | 576.55 g·mol⁻¹ | C29H28N4O9 | 5 MG
6-FAM-PEG3-Azide is a fluorescein-based azide reagent for click-chemistry conjugation to alkyne-containing biomolecules, commonly used to label oligonucleotides. It combines a 6-carboxyfluorescein fluorophore with a PEG3 spacer and an azide group to enable efficient copper-catalyzed azide-alkyne cycloaddition.
- Provides a 6-FAM fluorophore with Ex 498 nm and Em 532 nm.
- Includes a PEG3 spacer to improve solubility and reduce steric hindrance.
- Azide functionality enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- High purity suitable for labeling applications (≈98%).
- Soluble in DMSO at 50 mg/mL; ultrasonic agitation may be recommended.
- Powder stable at -20°C; store solutions frozen for long-term stability.
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.
- Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
- Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
- Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
- Arrests both HCC827 and H1975 cell lines at G1 phase.
Apexbio Technology LLC Cy5.5 alkyne (non-sulfonated) 1mg
Cy5 5 alkyne non-sulfonated is a near-infrared fluorescent cyanine derivative equipped with an alkyne functional group for click chemistry applications Through copper-catalyzed azide-alkyne cycloaddition (CuAAC) it forms covalent conjugates with azide-containing biomolecules metabolites or small-molecule ligands Cy5 5 alkyne non-sulfonated is primarily soluble in organic solvents aqueous solutions containing organic co-solvent such as DMSO may be used during conjugation Based on these chemical properties Cy5 5 alkyne non-sulfonated holds research potential in labeling nucleic acids peptides proteins lipids and other biomolecules for biomedical imaging tissue distribution evaluation and related pharmaceutical research applications
Cayman Chemical CLS-MPEG 2000 5mg
A PEGylated form of cholesterol; has been used in the synthesis of liposomes for targeted drug delivery
ABclonal Technology HIF1/ARNT Rabbit mAb
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus where it promotes the expression of genes involved in xenobiotic metabolism This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1 Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias Alternative splicing results in multiple transcript variants
ABclonal Technology SREK1 Rabbit pAb
This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MOLECULAR DEPOT LLC Pepsin Digested BSA - 50 mL
Pepsin Digested BSA consists of an enzyme-hydrolyzed version of BSA with various applications in biochemistry reagents formulation and more Pepsin-hydrolyzed BSA consists of a collection of small peptides that can minimize non-specific interactions For in vitro research use only
TARGETMOL CHEMICALS INC TCO-PEG4-NHS ester 25MG
Also available in 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).
Medchemexpress LLC Protac EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | C55H70N12O4S | 5 MG
PROTAC designed to selectively target and induce degradation of mutant forms of the epidermal growth factor receptor (EGFR). Demonstrates potent degradation of EGFRdel19 and EGFRL858R/T790M in cellular assays and inhibits growth of EGFR-driven cancer cell lines. Supplied as a high-purity research reagent with recommended solvent and storage conditions.
- Targets mutant EGFR, inducing degradation of activating and resistance variants.
- Demonstrated cellular potency with low-nanomolar DC50 values.
- High reported purity suitable for biochemical and cellular studies.
- Soluble in DMSO at 100 mg/mL; may require ultrasonic treatment.
- Store protected from light and under inert atmosphere; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Alkyne-PEG2-iodide | 1234387-33-7 | C7H11IO2 | 100 MG
Alkyne-PEG2-iodide | 1234387-33-7 | C7H11IO2 | 100 MG
Medchemexpress LLC Mal-Ph-CONH-PEG4-NHS ester | 1263044-88-7 | 561.54 | 50 MG
Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable 4 unit PEG ADC linker. It is utilized in the synthesis of antibody-drug conjugates (ADCs), which consist of an antibody attached to an ADC cytotoxin via an ADC linker.
- Non-cleavable 4 unit PEG ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Applicable as laboratory chemicals
- Suitable for the manufacture of substances