Protein Modification Reagents
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 572245291
Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 572245291
Medchemexpress LLC 1h-pyrrole-2,5-dione, 1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)- | 1262681-30-0 | 99.7% | 311.33 | 25 MG
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing azide groups
- Appearance: Colorless to light yellow oil
Medchemexpress LLC (R)-1-Amino-18-(3,4-bis((4-fluorobenzyl)oxy)phenoxy)-3,6,9,12-tetraoxa-15-azaoctadecan-17-ol | 99.5% | 634.71 | 5 MG
YT 6-2-PEG3-C2-NH2 is the p62/SQSTM1 targeting, autophagy-targeting ligand-linker conjugate of AUTOTAC ATC-324, which is an bivalent AR (Androgen Receptor) degrader. It can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa.
- P62/SQSTM1 targeting
- Autophagy-targeting ligand-linker conjugate
- Reduces nuclear AR levels
- Downregulates target gene expression of AR and AR-v7
- Degradation effect on common AR mutants in PCa
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 | C22H35NO8 | 10 MG
endo-BCN-PEG4-acid is a cleavable four-unit polyethylene glycol (PEG) linker containing a bicyclononyne (BCN) group that enables strain-promoted alkyne-azide cycloaddition (SPAAC). It is used as a copper-free click chemistry reagent for bioconjugation, including antibody-drug conjugate and PROTAC linker synthesis.
- Cleavable 4-unit PEG linker facilitating conjugation.
- BCN moiety enables copper-free SPAAC with azide groups.
- Molecular weight 441.52 and formula C22H35NO8.
- CAS number 1881221-47-1; high purity for research use.
- Storage recommendations include low-temperature conditions for long-term stability.
- Typical applications: ADC linker chemistry, bioconjugation, and PROTAC synthesis.
Medchemexpress LLC Diketone-PEG4-PFP ester | 2353409-84-2 | ≥97.0% | 647.58 | 25 MG
Diketone-PEG4-PFP ester is a PROTAC linker, specifically a PEG-based PROTAC linker, designed for use in the synthesis of PROTACs. PROTACs themselves are compounds that contain two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- Diketone-PEG4-PFP ester is a PEG-based PROTAC linker.
- It is used in the synthesis of PROTACs.
- PROTACs utilize the ubiquitin-proteasome system for selective degradation of target proteins.
Medchemexpress LLC Bromoacetamido-PEG4-acid | 1807518-67-7 | MFCD28950779 | 96.8% | 386.24 g·mol⁻¹ | C13H24BrNO7 | 500 MG
Bromoacetamido-PEG4-acid is a 4-unit polyethylene glycol (PEG4) linker bearing a bromoacetamido functional group. It is used as a cleavable spacer and reactive handle in the synthesis of PROTACs and antibody-drug conjugates (ADCs), providing aqueous solubility and sites for nucleophilic conjugation.
- 4-unit PEG spacer improves solubility and flexibility
- Bromoacetamido reactive group enables nucleophilic substitution conjugation
- Molecular weight 386.24 g·mol⁻¹
- CAS number 1807518-67-7
- Purity 96.8% (as supplied)
- Typical package size 500 MG
American Research Products Inc AMERICAN RESEARCH PRODUCTS INC
5000597440 CANINE ANTI-PEG IGM ELISA KIT
Medchemexpress LLC m-PEG4-MS | 130955-37-2 | ≥95.0% | 286.34 | C10H22O7S | 250 MG
m-PEG4-MS is a PEG-based linker used in the synthesis of PROTAC molecules and as a cleavable linker in antibody-drug conjugates (ADCs).
- PEG-based linker for PROTACs and ADCs.
- CAS number: 130955-37-2.
- Purity: ≥95.0%.
- Molecular formula: C10H22O7S.
- Molecular weight: 286.34 g/mol.
- Package size: 250 mg.
Medchemexpress LLC DBCO-PEG2-NHS ester | 2585653-12-7 | 849001 | C30H31N3O8 | 25 MG
DBCO-PEG2-NHS ester is a click chemistry reagent that contains an azide group and an NHS ester. The NHS ester reacts specifically and efficiently with primary amines under neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG spacer arm enhances water solubility and provides a long, flexible connection to minimize steric hindrance. DBCO is used for copper-free Click Chemistry reactions. It is intended for research use only.
- Contains an azide group and an NHS ester
- NHS ester reacts specifically and efficiently with primary amines
- Hydrophilic PEG spacer arm enhances water solubility
- Minimizes steric hindrance in ligation
- Used for copper-free click chemistry reactions
- Reagent grade
- For research use only
eMolecules Bis-Bromoacetamido-PEG11 | Broadpharm |786.549 | C28H54Br2N2O13 | 0.000 | BrCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 550804565
Bis-Bromoacetamido-PEG11 | Broadpharm |786.549 | C28H54Br2N2O13 | 0.000 | BrCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 550804565
Medchemexpress LLC Thiol-PEG2-t-butyl ester | 1398044-50-2 | MFCD22574781 | 96.0% | 250.35 g·mol-1 | C11H22O4S | 5 MG
Thiol-PEG2-t-butyl ester is a short polyethylene glycol (PEG2) linker bearing a tert-butyl-protected thiol, designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It provides a hydrophilic spacer and a masked thiol functionality for selective deprotection and conjugation in medicinal chemistry workflows.
- Provides a short PEG2 spacer to improve solubility and flexibility.
- Contains a tert-butyl-protected thiol for masked thiol chemistry.
- Suitable for incorporation into bifunctional PROTAC molecules.
- Available in research-scale pack sizes for synthetic work.
- Molecular weight ~250.35 g·mol-1 and formula C11H22O4S.
Medchemexpress LLC Cholesterol-PEG-maleimide | 95.1% | 2000 Da (average) | 10 MG
Cholesterol-PEG-maleimide (average MW 2000) is a cholesterol-terminated polyethylene glycol conjugate bearing a maleimide reactive group. It self-assembles in aqueous media and is used to modify liposomes or nanoparticles and to covalently attach thiol-containing ligands via maleimide-thiol chemistry.
- Maleimide functional group reacts selectively with thiol groups to form stable thioether bonds.
- Cholesterol terminus anchors into lipid bilayers for stable surface modification.
- PEG (average MW 2000) provides steric stabilization and improved circulation time.
- Amphiphilic structure facilitates liposome and nanoparticle formulation.
- Available in small research pack sizes suitable for formulation and conjugation studies.
Medchemexpress LLC 2,5-pyrrolidinedione derivative (PEG1 NHS ester) | 173414-89-6 | 97.0% | 627.55 g/mol | C26H33N3O15 | 100 MG
m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable, single-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker bearing an N-hydroxysuccinimide (NHS) ester for amine coupling. Supplied as a solid for research use, it provides a stable, non-cleavable spacer that improves solubility and facilitates conjugation.
- Non-cleavable single-unit PEG linker for stable spacing
- NHS ester functionality for efficient amine conjugation
- Improves payload solubility
- Supplied as a solid with ~97.0% purity (NMR)
- Available in multiple sample sizes for research (50 mg-1 g)
Medchemexpress LLC Pomalidomide-5'-peg8-c2-cooh | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 10 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate that links a pomalidomide E3 ligase ligand to an eight-unit polyethylene glycol (PEG8) spacer terminated with a two-carbon carboxylic acid. It is intended as a building block for PROTAC synthesis and other E3 ligase recruitment applications.
- Used as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Conjugate of pomalidomide and a PEG8 linker with a C2 carboxylic acid terminus.
- High purity: 98.2%.
- Molecular weight 697.73 g/mol; formula C32H47N3O14.
- Soluble in DMSO (100 mg/mL) and suitable in vivo formulations (≥2.5 mg/mL).
- Storage: pure form -20°C (3 years) or 4°C (2 years).
Medchemexpress LLC 2-((1E,3Z)-3-(1-(1-((E)-Cyclooct-2-en-1-yloxy)-1,12-dioxo-5,8-dioxa-2,11-diazaheptadecan-17-yl)-3,3- | 91.1% | 775.46 | C45H63ClN4O5 | 10 MG
Cy3-PEG2-TCO is a Cy3-based fluorescent reagent containing a two-unit PEG spacer and a trans-cyclooctene (TCO) functional group. It is designed for rapid bioorthogonal conjugation via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing partners and is intended for research use in labeling, imaging, and bioconjugation workflows.
- Fluorescent Cy3 dye derivative suitable for imaging and labeling.
- PEG2 spacer improves solubility and reduces steric hindrance during conjugation.
- TCO functional group enables fast, selective iEDDA click reactions with tetrazines.
- Supplied as a solid with color ranging brown to reddish brown.
- High purity (~91.1%) with molecular weight 775.46 g·mol-1.
- Store protected from light under nitrogen at -20°C; in solvent, store at -80°C for long term.